neuroinflammation

Single-cell profiling identifies distinct hormonal, immunologic, and inflammatory signatures of endometriosis-constituting cells Sun Shin; Youn-Jee Chung; Seong Won Moon; Eun Ji Choi; Mee-Ran Kim; Yeun-Jun Chung; Sug Hyung Lee Endometriosis consists of ectopic endometrial epithelial cells...

Frataxin Deficiency Drives a Shift from Mitochondrial Metabolism to Glucose Catabolism, Triggering an Inflammatory Phenotype in Microglia Francesca Sciarretta; Fabio Zaccaria; Andrea Ninni; Veronica Ceci; Riccardo Turchi; Savina Apolloni; Valerio Chiurchiu; Marta Tiberi; Nadia D'Ambrosi; Silvia...

SARS-CoV-2 induces acute neurological signs while Calcitonin Gene-Related Peptide CGRP signaling blockade reduces interleukin 6 IL-6 release and weight loss in mouse models Shafaqat M Rahman; David W Buchholz; Brian Imbiakha; Mason C Jaeger; Justin Leach; Raven M Osborn; Ann O Birmingham...

Published version linked in this later post here Preprint Abstract The COVID-19 pandemic caused by SARS-CoV-2 has triggered a consequential public health crisis of post-acute sequelae of COVID-19 (PASC), sometimes referred to as long COVID. The mechanisms of the heterogeneous persistent...

COVID-19 Induces Neuroinflammation and Suppresses Peroxisomes in the Brain A. Roczkowsky; D. Limonta; J. P. Fernandes; W. G. Branton; M. Clarke; B. Hlavay; R. S. Noyce; J. T. Joseph; N. S. Ogando; S. K. Das; M. Elaish; N. Arbour; D. H. Evans; K. Langdon; T. C. Hobman; C. Power Objective...

Distinct molecular profiles of skull bone marrow in health and neurological disorders Zeynep Ilgin Kolabas; Louis B. Kuemmerle; Robert Perneczky; Benjamin Förstera; Selin Ulukaya; Mayar Ali; Saketh Kapoor; Laura M. Bartos; Maren Büttner; Ozum Sehnaz Caliskan; Zhouyi Rong; Hongcheng Mai; Luciano...

Platelet factors attenuate inflammation and rescue cognition in ageing Schroer, Adam B.; Ventura, Patrick B.; Sucharov, Juliana; Misra, Rhea; Chui, M. K. Kirsten; Bieri, Gregor; Horowitz, Alana M.; Smith, Lucas K.; Encabo, Katriel; Tenggara, Imelda; Couthouis, Julien; Gross, Joshua D.; Chan...

Differential effects of SARS-CoV-2 variants on central nervous system cells and blood–brain barrier functions Background Although mainly causing a respiratory syndrome, numerous neurological symptoms have been identified following of SARS-CoV-2 infection. However, how the virus affects the...

The Human Microglia Atlas HuMicA Unravels Changes in Homeostatic and Disease-Associated Microglia Subsets across Neurodegenerative Conditions Ricardo Martins-Ferreira; Josep Calafell-Segura; Barbara Leal; Javier Rodriguez-Ubreva; Elisabetta Mereu; Paulo Pinho e Costa; Esteban Ballestar...

Tissue-resident memory T cells invade the brain parenchyma in multiple sclerosis white matter lesions Fransen, Nina L; Hsiao, Cheng-Chih; van der Poel, Marlijn; Engelenburg, Hendrik J; Verdaasdonk, Kim; Vincenten, Maria C J; Remmerswaal, Ester B M; Kuhlmann, Tanja; Mason, Matthew R J; Hamann...

Longitudinal positron emission tomography and postmortem analysis reveals widespread neuroinflammation in SARS-CoV-2 infected rhesus macaques Nieuwland, Juliana M.; Nutma, Erik; Philippens, Ingrid H. C. H. M.; Böszörményi, Kinga P.; Remarque, Edmond J.; Bakker, Jaco; Meijer, Lisette; Woerdman...

No evidence for the association between COVID-19 and neuroinflammation: A diffusion basis spectrum imaging study. Wei Zhang; Aaron J Gorelik; Qing Wang; Sara A Norton; Tamara Hershey; Janine D Bijsterbosch; Ryan Bogdan COVID continues to be a major international public health concern, the...

Hippocampal subfield abnormalities and biomarkers of pathologic brain changes: from SARS-CoV-2 acute infection to post-COVID syndrome Maria Díez-Cirarda; Miguel Yus-Fuertes; Rafael Sanchez-Sanchez; Javier J. Gonzalez-Rosa; Gabriel Gonzalez-Escamilla; Lidia Gil-Martínez; Cristina Delgado-Alonso...

Extensive Brain Pathologic Alterations Detected with 7.0-T MR Spectroscopic Imaging Associated with Disability in Multiple Sclerosis Eva Heckova; Assunta Dal-Bianco; Bernhard Strasser; Gilbert J. Hangel; Alexandra Lipka; Stanislav Motyka; Lukas Hingerl; Paulus S. Rommer; Thomas Berger; Petra...

Perivascular spaces and their role in neuroinflammation Benjamin V. Ineichen; Serhat V. Okar; Steven T. Proulx; Britta Engelhardt; Hans Lassmann; Daniel S. Reich It is uncontested that perivascular spaces play critical roles in maintaining homeostasis and priming neuroinflammation. However...

Large scale phenotyping of long COVID inflammation reveals mechanistic subtypes of disease One in ten SARS-CoV-2 infections result in prolonged symptoms termed ‘long COVID’, yet disease phenotypes and mechanisms are poorly understood. We studied the blood proteome of 719 adults, grouped by...

Key Points Question Is translocator protein distribution volume (TSPO VT), an index of gliosis (an inflammatory change), measured by positron emission tomography, elevated in the brain after acute COVID-19 infection with sequelae of depressive and cognitive symptoms? Findings In this...

Free-water-corrected diffusion and adrenergic/muscarinic antibodies in myalgic encephalomyelitis/chronic fatigue syndrome Yukio Kimura; Wakiro Sato; Norihide Maikusa; Miho Ota; Yoko Shigemoto; Emiko Chiba; Elly Arizono; Hiroyuki Maki; Isu Shin; Keiko Amano; Hiroshi Matsuda; Takashi Yamamura...

Abnormal brain diffusivity in participants with persistent neuropsychiatric symptoms after COVID-19 Huajun Liang; Thomas Ernst; Kenichi Oishi; Meghann C. Ryan; Edward Herskovits; Eric Cunningham; Eleanor Wilson; Shyamasundaran Kottilil; Linda Chang Objectives We aimed to compare brain white...

The Pathological Activation of Microglia Is Modulated by Sexually Dimorphic Pathways O'Connor, Jennifer L.; Nissen, Jillian C. Microglia are the primary immunocompetent cells of the central nervous system (CNS). Their ability to survey, assess and respond to perturbations in their local...