Platelet factors attenuate inflammation and rescue cognition in ageing, 2023, Schroer et al.

Platelet factors attenuate inflammation and rescue cognition in ageing
Schroer, Adam B.; Ventura, Patrick B.; Sucharov, Juliana; Misra, Rhea; Chui, M. K. Kirsten; Bieri, Gregor; Horowitz, Alana M.; Smith, Lucas K.; Encabo, Katriel; Tenggara, Imelda; Couthouis, Julien; Gross, Joshua D.; Chan, June M.; Luke, Anthony; Villeda, Saul A.

Identifying therapeutics to delay, and potentially reverse, age-related cognitive decline is critical in light of the increased incidence of dementia-related disorders forecasted in the growing older population1.

Here we show that platelet factors transfer the benefits of young blood to the ageing brain. Systemic exposure of aged male mice to a fraction of blood plasma from young mice containing platelets decreased neuroinflammation in the hippocampus at the transcriptional and cellular level and ameliorated hippocampal-dependent cognitive impairments. Circulating levels of the platelet-derived chemokine platelet factor 4 (PF4) (also known as CXCL4) were elevated in blood plasma preparations of young mice and humans relative to older individuals. Systemic administration of exogenous PF4 attenuated age-related hippocampal neuroinflammation, elicited synaptic-plasticity-related molecular changes and improved cognition in aged mice. We implicate decreased levels of circulating pro-ageing immune factors and restoration of the ageing peripheral immune system in the beneficial effects of systemic PF4 on the aged brain. Mechanistically, we identified CXCR3 as a chemokine receptor that, in part, mediates the cellular, molecular and cognitive benefits of systemic PF4 on the aged brain.

Together, our data identify platelet-derived factors as potential therapeutic targets to abate inflammation and rescue cognition in old age.

Link | PDF (Nature)

 

See also —

Platelet-derived exerkine CXCL4/platelet factor 4 rejuvenates hippocampal neurogenesis and restores cognitive function in aged mice (2023, Nature Communications)
Platelet factors are induced by longevity factor klotho and enhance cognition in young and aging mice (2023, Nature Aging)

 

The multi-million dollar question. They showed some corresponding aspects in humans.

They also treated the mice with human PF4.

Similarly, in the Nature Aging paper —

The Nature Comms paper comments —

It is recognised that while exercise is associated with good brain health, with co-morbidities exercise is not always possible. They are looking at what the "goodness factor" from exercise is to see if it might be synthesised and delivered without the... unnecessary sweat.

 

See also thread for Platelet-derived exerkine CXCL4/platelet factor 4 rejuvenates hippocampal neurogenesis and restores cognitive function in aged mice (2023)

 

I prefer to use sloe gin.

 

From @MSEsperanza

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