long covid

What’s New in the Search for a Long COVID Cure? Effective therapies that target the condition’s root causes could be a few years away. Interviewing Michael Peluso, most recently author of Reduced exercise capacity, chronotropic incompetence, and early systemic inflammation in cardiopulmonary...

Comorbidity genetic risk and pathways impact SARS-CoV-2 infection outcomes Jaros, Rachel K.; Fadason, Tayaza; Cameron-Smith, David; Golovina, Evgeniia; O’Sullivan, Justin M. Understanding the genetic risk and mechanisms through which SARS-CoV-2 infection outcomes and comorbidities interact to...

Large scale phenotyping of long COVID inflammation reveals mechanistic subtypes of disease One in ten SARS-CoV-2 infections result in prolonged symptoms termed ‘long COVID’, yet disease phenotypes and mechanisms are poorly understood. We studied the blood proteome of 719 adults, grouped by...

Prophylactic rivaroxaban in the early post-discharge period reduces the rates of hospitalization for atrial fibrillation and incidence of sudden cardiac death during long-term follow-up in hospitalized COVID-19 survivors Fiedler, Lukas; Motloch, Lukas J.; Dieplinger, Anna-Maria; Jirak, Peter...

The actual study start date was March 2023, the estimated primary end date was 1 June 2023 and the estimated study completion date is 1 October 2023. Clinical Trials link: https://clinicaltrials.gov/ct2/show/NCT05813587?term=Meplazumab&draw=2&rank=8 Randomized, double-blind...

Long COVID: Costs for the German economy and health care and pension system Gandjour, Afschin Background Patients with acute COVID-19 can develop persistent symptoms (long/post COVID-19 syndrome). This study aimed to project the economic, health care, and pension costs due to long/post-COVID-19...

This review highlights the well-known immunomodulatory effect of mesenchymal stem cells (MSCs) as an alternative therapy for inflammatory and autoimmune diseases. Recent studies have shown that MSC-derived extracellular vesicles (EVs), including exosomes, exhibit similar therapeutic effects. The...

“We’re drowning and we’re alone”: a qualitative study of the lived experience of people experiencing persistent post-COVID-19 symptoms Donna Goodridge; Thomas N. Lowe; Shuang Cai; Flinn N. Herriot; Rachel V. Silverberg; Michael Heynen; Kelly C. Hall; Jaimie Peters; Scotty Butcher; Taofiq...

Prolonged T-cell activation and long COVID symptoms independently associate with severe COVID-19 at 3 months Marianna Santopaolo; Michaela Gregorova; Fergus Hamilton; David Arnold; Anna Long; Aurora Lacey; Alice Halliday; Holly Baum; Kristy Hamilton; Rachel Milligan; Elizabeth Oliver; Olivia...

The effect of hyperbaric oxygen therapy on myocardial function in post-COVID-19 syndrome patients: a randomized controlled trial Leitman, Marina; Fuchs, Shmuel; Tyomkin, Vladimir; Hadanny, Amir; Zilberman-Itskovich, Shani; Efrati, Shai Post-COVID-19 condition refers to a range of persisting...

Plasma proteome of Long-COVID patients indicates HIF-mediated vasculo-proliferative disease with impact on brain and heart function Iosef, Cristiana; Knauer, Michael J.; Nicholson, Michael; Van Nynatten, Logan R.; Cepinskas, Gediminas; Draghici, Sorin; Han, Victor K. M.; Fraser, Douglas D. Aims...

Persistent serum protein signatures define an inflammatory subcategory of long COVID Talla, Aarthi; Vasaikar, Suhas V.; Szeto, Gregory Lee; Lemos, Maria P.; Czartoski, Julie L.; MacMillan, Hugh; Moodie, Zoe; Cohen, Kristen W.; Fleming, Lamar B.; Thomson, Zachary; Okada, Lauren; Becker, Lynne A...

Date & Time : Fri, Jun 16 5:00 PM - 7:00 PM **Events may have been canceled or postponed. Please contact the venue to confirm the event. https://www.independent.com/events/movie-screening-movie-about-m-e-long-covid-event/

A systematic review and meta-analysis of long-term sequelae of COVID-19 2-year after SARS-CoV-2 infection: A call to action for neurological, physical, and psychological sciences Abstract Long-term sequelae conditions of COVID-19 at least 2-year following SARS-CoV-2 infection are unclear and...

Impact of fatigue as the primary determinant of functional limitations among patients with post-COVID-19 syndrome: a cross-sectional observational study Sarah Walker; Henry Goodfellow; Patra Pookarnjanamorakot; Elizabeth Murray; Julia Bindman; Ann Blandford; Katherine Bradbury; Belinda Cooper...

Not sure how the following paragraph even made it in when we're talking about a 31% increase in GP visits for this in 25-44 year olds... Back to reality... Article

Critical COVID-19 disease is accompanied by depletion of plasma tryptophan (TRY) and increases in indoleamine-dioxygenase (IDO)-stimulated production of neuroactive tryptophan catabolites (TRYCATs), including kynurenine (KYN). The TRYCAT pathway has not been studied extensively in association...

Key Points Question Is translocator protein distribution volume (TSPO VT), an index of gliosis (an inflammatory change), measured by positron emission tomography, elevated in the brain after acute COVID-19 infection with sequelae of depressive and cognitive symptoms? Findings In this...

Recovery and symptom trajectories up to two years after SARS-CoV-2 infection: population based, longitudinal cohort study Tala Ballouz; Dominik Menges; Alexia Anagnostopoulos; Anja Domenghino; Hélène E Aschmann; Anja Frei; Jan S Fehr; Milo A Puhan Objective To evaluate longer term symptoms and...

Long-Term Adverse Effects of Mild COVID-19 Disease on Arterial Stiffness, and Systemic and Central Hemodynamics: A Pre-Post Study Podrug, Mario; Koren, Pjero; Dražić Maras, Edita; Podrug, Josip; Čulić, Viktor; Perissiou, Maria; Bruno, Rosa Maria; Mudnić, Ivana; Boban, Mladen; Jerončić, Ana...