1. Sign our petition calling on Cochrane to withdraw their review of Exercise Therapy for 'CFS'.
    Dismiss Notice
  2. Guest, the 'News in Brief' for the week beginning 25th November 2024 is here.
    Dismiss Notice
  3. Welcome! Read the Core Purpose and Values of our forum.
    Dismiss Notice

Trial Report Effects of six-month creatine supplementation on patient- and clinician-reported outcomes, and tissue creatine levels (...), 2023, Slankamenac et al

Discussion in 'Long Covid research' started by Wyva, Sep 25, 2023.

Tags:
  1. Wyva

    Wyva Senior Member (Voting Rights)

    Messages:
    1,749
    Location:
    Budapest, Hungary
    Full title:
    Effects of six-month creatine supplementation on patient- and clinician-reported outcomes, and tissue creatine levels in patients with post-COVID-19 fatigue syndrome

    Abstract

    Dietary creatine has been recently put forward as a possible intervention strategy to reduce post-COVID-19 fatigue syndrome yet no clinical study so far evaluated its efficacy and safety for this perplexing condition. In this parallel-group, randomized placebo-controlled double-blind trial, we analyzed the effects of 6-month creatine supplementation (4 g of creatine monohydrate per day) on various patient- and clinician-reported outcomes, and tissue creatine levels in 12 patients with post-COVID-19 fatigue syndrome.

    Creatine intake induced a significant increase in tissue creatine levels in vastus medialis muscle and right parietal white matter compared to the baseline values at both 3-month and 6-month follow-ups (p < .05). Two-way analysis of variance with repeated measures revealed a significant difference (treatment vs. time interaction) between interventions in tissue creatine levels (p < .05), with the creatine group was superior to placebo to augment creatine levels at vastus medialis muscle, left frontal white matter, and right parietal white matter.

    Creatine supplementation induced a significant reduction in general fatigue after 3 months of intake compared to baseline values (p = .04), and significantly improved scores for several post-COVID-19 fatigue syndrome-related symptoms (e.g., ageusia, breathing difficulties, body aches, headache, and difficulties concentrating) at 6-month follow-up (p < .05). Taking creatine for 6 months appears to improve tissue bioenergetics and attenuate clinical features of post-COVID-19 fatigue syndrome; additional studies are warranted to confirm our findings in various post-COVID-19 cohorts.

    Open access: https://onlinelibrary.wiley.com/doi/10.1002/fsn3.3597
     
    Wyva, Sep 25, 2023
    #1
    forestglip, Murph, Hutan and 4 others like this.
  2. Hutan

    Hutan Moderator Staff Member

    Messages:
    29,562
    Location:
    Aotearoa New Zealand
    The abstract says that creatine supplementation increased tissue creatine levels and that people taking creatine had less symptoms over time. But it doesn't say that the reduction in symptoms in the people with creatine supplementation was more than in the people without creatine supplementation.
     
    Hutan, Sep 30, 2024
    #2
    forestglip and Peter Trewhitt like this.
  3. Hutan

    Hutan Moderator Staff Member

    Messages:
    29,562
    Location:
    Aotearoa New Zealand
     
    Hutan, Sep 30, 2024
    #3
    forestglip, shak8 and Peter Trewhitt like this.
  4. Hutan

    Hutan Moderator Staff Member

    Messages:
    29,562
    Location:
    Aotearoa New Zealand
    Looking at the data, there was a bit of a trend to the creatine group having slightly better results than the placebo group in terms of fatigue and time to exhaustion. But the small sample size and the small differences means that nothing much was statistically significant.

    e.g. Multidimensional Fatigue Inventory (summing the values for the five sub-categories)
    Creatine group: baseline 62.3; 3 months 60.2; 6 months 61.4
    Placebo group: baseline 60.4; 3 months 61.6; 6 months 65.5
     
    Hutan, Sep 30, 2024
    #4
    forestglip and Peter Trewhitt like this.

Share This Page