immunology

  1. bicentennial

    BiteSized Immunology: developing online resource outlines major learning points (Spanish version too, maybe still needs help if under construction)

    From the British and Spanish Societies for Immunology BiteSized Immunology BiteSized Immunology is a developing online resource designed to form a comprehensive guide to the immune system, yet approaching the topic via punchy, easy-to-digest, entries that outline major learning points. You...
  2. rvallee

    Nature: ‘It’s all gone’: CAR-T therapy forces autoimmune diseases into remission

    ‘It’s all gone’: CAR-T therapy forces autoimmune diseases into remission https://www.nature.com/articles/d41586-023-03968-6 Engineered immune cells have given 15 people with once-debilitating autoimmune disorders a new lease on life, free from fresh symptoms or treatments. The results raise...
  3. E

    Immunological profiling in long COVID: overall low grade inflammation and T-lymphocyte senescence and increased monocyte activation..., Hellemonds+

    Immunological profiling in long COVID: overall low grade inflammation and T-lymphocyte senescence and increased monocyte activation correlating with increasing fatigue severity Background: Many patients with SARS-CoV-2 infection develop long COVID with fatigue as one of the most disabling...
  4. E

    SARS-CoV-2-specific T cell therapy for severe COVID-19: a randomized phase 1/2 trial, 2023, Yannaki et al

    SARS-CoV-2-specific T cell therapy for severe COVID-19: a randomized phase 1/2 trial Abstract Despite advances, few therapeutics have shown efficacy in severe coronavirus disease 2019 (COVID-19). In a different context, virus-specific T cells have proven safe and effective. We conducted a...
  5. Mij

    The battle between the innate immune cGAS-STING signaling pathway and human herpesvirus infection, 2023, Ximing Jin et al

    The incidence of human herpesvirus (HHVs) is gradually increasing and has affected a wide range of population. HHVs can result in serious consequences such as tumors, neonatal malformations, sexually transmitted diseases, as well as pose an immense threat to the human health. The cGAS-STING...
  6. Sly Saint

    Review Surveying the Metabolic and Dysfunctional Profiles of T Cells and NK Cells in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome 2023, Maya

    Abstract: Millions globally suffer from myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). The inflammatory symptoms, illness onset, recorded outbreak events, and physiological variations provide strong indications that ME/CFS, at least sometimes, has an infectious origin, possibly...
  7. rvallee

    Microglia Transcriptional Profiling in Major Depressive Disorder Shows Inhibition of Cortical Gray Matter Microglia, 2023, Huitinga et al

    Microglia Transcriptional Profiling in Major Depressive Disorder Shows Inhibition of Cortical Gray Matter Microglia https://www.biologicalpsychiatryjournal.com/article/S0006-3223(23)01239-8/fulltext Biological psychiatry Microglia have been implicated in the pathophysiology of major depressive...
  8. Andy

    Review An understanding of the immune dysfunction in susceptible people who develop the post-viral fatigue syndromes ME/CFS and Long Covid, 2023 Walker et al

    Abstract Viral infection in most people results in a transient immune/inflammatory response resulting in elimination of the virus and recovery where the immune system returns to that of the pre-infectious state. In susceptible people by contrast there is a transition from an acute immune...
  9. E

    The immunology of long COVID, 2023, Altmann et al

    The immunology of long COVID Abstract Long COVID is the patient-coined term for the disease entity whereby persistent symptoms ensue in a significant proportion of those who have had COVID-19, whether asymptomatic, mild or severe. Estimated numbers vary but the assumption is that, of all...
  10. rvallee

    Higher immune-related gene expression in major depression is independent of CRP levels: results from the BIODEP study, 2023, Pariante et el

    Higher immune-related gene expression in major depression is independent of CRP levels: results from the BIODEP study https://www.nature.com/articles/s41398-023-02438-x Abstract (paragraphs mine) Compelling evidence demonstrates that some individuals suffering from major depressive disorder...
  11. Mij

    Neuro-PASC is characterized by enhanced CD4+ and diminished CD8+ T cell responses to SARS-CoV-2 Nucleocapsid protein, 2023, Lavanya Visvabharathy

    Introduction: Many people with long COVID symptoms suffer from debilitating neurologic post-acute sequelae of SARS-CoV-2 infection (Neuro-PASC). Although symptoms of Neuro-PASC are widely documented, it is still unclear whether PASC symptoms impact virus-specific immune responses. Therefore, we...
  12. Sly Saint

    Tissue injury and leukocyte changes in post-acute sequelae of SARS-CoV-2: review of 2833 post-acute patient outcomes, 2023 Islam et al

    Tissue injury and leukocyte changes in post-acute sequelae of SARS-CoV-2: review of 2833 post-acute patient outcomes per immune dysregulation and microbial translocation in long COVID Abstract A significant number of persons with coronavirus disease 2019 (COVID-19) experience persistent...
  13. Andy

    Identifying platelet-derived factors as amplifiers of B. burgdorferi-induced cytokine production, 2022, Kerstholt et al

    Abstract Previous studies have shown that monocytes can be ‘trained’ or tolerized by certain stimuli to respond stronger or weaker to a secondary stimulation. Rewiring of glucose metabolism was found to be important in inducing this phenotype. As we previously found that Borrelia burgdorferi...
  14. Hutan

    MYB orchestrates T cell exhaustion and response to checkpoint inhibition, Tsui, 2022

    https://www.nature.com/articles/s41586-022-05105-1 Abstract CD8+ T cells that respond to chronic viral infections or cancer are characterized by the expression of inhibitory receptors such as programmed cell death protein 1 (PD-1) and by the impaired production of cytokines. This state of...
  15. SNT Gatchaman

    Recovering or Persisting: The Immunopathological Features of SARS-CoV-2 Infection in Children, 2022, Buonsenso et al

    Recovering or Persisting: The Immunopathological Features of SARS-CoV-2 Infection in Children Buonsenso D, Valentini P, De Rose C, Tredicine M, Pereyra Boza MdC, Camponeschi C, Morello R, Zampino G, Brooks AES, Rende M, Ria F, Sanguinetti M, Delogu G, Sali M, Di Sante G, on behalf of the...
  16. rvallee

    Unexplained post-acute infection syndromes, 2021, Choutka, Iwasaki, Hornig et al

    Full title: Unexplained post-acute infection syndromes Authors: Jan Choutka, Viraj Jansari, Mady Hornig & Akiko Iwasaki Published: Nature, 18 May 2022 Abstract SARS-CoV-2 is not unique in its ability to cause post-acute sequelae; certain acute infections have long been associated with an...
  17. rvallee

    Reduced Cell Surface Levels of C-C Chemokine Receptor 5 and Immunosuppression in Long Coronavirus Disease 2019 Syndrome, 2022, Yang et al

    In an exploratory trial treating “long COVID” with the CCR5-binding antibody leronlimab, we observed significantly increased blood cell surface CCR5 in treated symptomatic responders but not in nonresponders or placebo-treated participants. These findings suggest an unexpected mechanism of...
  18. Wyva

    How mycobacterium tuberculosis infection could lead to the increasing risks of CFS and the potential immunological effects (...), 2022, Yang et al

    Full title: How mycobacterium tuberculosis infection could lead to the increasing risks of chronic fatigue syndrome and the potential immunological effects: a population-based retrospective cohort study Abstract Background Chronic fatigue syndrome (CFS) has been shown to be associated with...
  19. J

    Targeting the Monocytic-Endothelial-Platelet Axis with Maraviroc and Pravastatin as a Therapeutic Option to Treat Long COVID/ Patterson/PP

    Preprint https://www.researchsquare.com/article/rs-1344323/v1 Post-acute sequelae of COVID (PASC), or long COVID, is a multisystem complication of SARS-CoV-2 infection that continues to debilitate millions worldwide thus highlighting the public health importance of identifying effective...
  20. Arvo

    SARS-CoV-2 awakens ancient retroviral genes and the expression of proinflammatory HERV-W envelope protein in COVID-19 patients, 2023, Charvet et al.

    :emoji_warning: At this point it's still a preprint. Abstract: As most of you know, in the 80s researchers were excited about several (and separate) finds of retroviral activity in what we now call ME/CFS patients. The main researcher was Elaine DeFreitas, whose finds got dismissed by UK...
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