immunology

  1. Andy

    Microbiota-derived acetate enables the metabolic fitness of the brain innate immune system during health and disease, 2021, Emy et al

    In mice. Highlights Altered metabolic features of microglia in the absence of host microbiota Bacteria-derived acetate modulates metabolic features of microglia during steady state Acetate regulates microglial functions during neurodegeneration Summary As tissue macrophages of the central...
  2. O

    A Short Corticosteroid Course Reduces Symptoms and Immunological Alterations Underlying Long-COVID, 2021, Utrero-Rico et al

    Abstract Despite the growing number of patients with persistent symptoms after acute SARS-CoV-2 infection, the pathophysiology underlying long-COVID is not yet well characterized, and there is no established therapy. We performed a deep immune profiling in nine patients with persistent symptoms...
    • ola_cohn
    • Thread
    • 2021 corticosteroids immunology integrins long covid paper prednisolone prednisone spain treatment
    • Replies: 8
    • Forum: Long Covid research
  3. Trish

    Insular cortex neurons encode and retrieve specific immune responses, 2021, Tamar Koren et al.

    https://www.cell.com/cell/pdf/S0092-8674(21)01223-X.pdf Research done in mice. Highlights Neuronal ensembles in the InsCtx are activated during peripheral inflammation Reactivation of these neurons is sufficient to retrieve peripheral inflammation These InsCtx neurons project to autonomic...
    • Trish
    • Thread
    • 2021 brain brain cells immunology inflammation insular cortex koren neuroimmune interactions paper
    • Replies: 15
    • Forum: Other health news and research
  4. Hutan

    Transcriptional Control of Complement Activation in an Exercise Model of CFS, 2009, Sorensen et al

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2583111/ Abstract Complement activation resulting in significant increases of C4a split product may be a marker of postexertional malaise in individuals with chronic fatigue syndrome (CFS). This study focused on identification of the transcriptional...
    • Hutan
    • Thread
    • 2009 c1q complement exercise immunology lectin mannose-binding lectin mbl me/cfs paper pgk1
    • Replies: 2
    • Forum: ME/CFS research
  5. Hutan

    Complement activation in a model of chronic fatigue syndrome, 2003, Sorensen et al

    Published in 2003 https://www.jacionline.org/article/S0091-6749(03)01546-X/fulltext Abstract Background: A need exists to identify biological markers in chronic fatigue syndrome (CFS). Objective: To use an exercise and/or allergen challenge to induce the symptoms of CFS and to identify a...
    • Hutan
    • Thread
    • 2003 allergy c3a c4a c5a complement exercise immunology paper sorensen
    • Replies: 11
    • Forum: ME/CFS research
  6. Sly Saint

    Complement Component C1q as a Potential Diagnostic Tool for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Subtyping, 2021, Castro-Marrero et al

    Abstract Background: Routine blood analytics are systematically used in the clinic to diagnose disease or confirm individuals’ healthy status. For myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), a disease relying exclusively on clinical symptoms for its diagnosis, blood analytics...
    • Sly Saint
    • Thread
    • 2021 biomarker c1q castro-marrero complement diagnosis etiology immunology me/cfs oedema paper spain subgroups swelling vitamin d
    • Replies: 32
    • Forum: ME/CFS research
  7. Andy

    Fine mapping of the major histocompatibility complex (MHC) in (ME/CFS) suggests involvement of both HLA class I and class II loci, 2021, Hajdarevic

    Full title: Fine mapping of the major histocompatibility complex (MHC) in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) suggests involvement of both HLA class I and class II loci Abstract The etiology of myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is unknown, but...
    • Andy
    • Thread
    • autoimmunity fluge genetics genomics hajdarevic hla hla-dqb1 immunology me/cfs mella mhc norway saugstad t-cells
    • Replies: 16
    • Forum: ME/CFS research
  8. J

    Immune-Based Prediction of COVID-19 Severity and Chronicity Decoded Using Machine Learning Patterson et al. 2021

    https://www.frontiersin.org/articles/10.3389/fimmu.2021.700782/full?utm_source=F-NTF&utm_medium=EMLX&utm_campaign=PRD_FEOPS_20170000_ARTICLE Expression of CCR5 and its cognate ligands have been implicated in COVID-19 pathogenesis, consequently therapeutics directed against CCR5 are being...
    • Jaybee00
    • Thread
    • bruce patterson ifny il-2 immunology interferon long covid post covid-19 syndrome t cells vegf
    • Replies: 2
    • Forum: ME/CFS research
  9. cassava7

    Divergent and self-reactive immune responses in the CNS of COVID-19 patients with neurological symptoms, Song et al., 2021

    Eric Song, Christopher M. Bartley, Ryan D. Chow, Thomas T. Ngo, Ruoyi Jiang, Colin R. Zamecnik, Ravi Dandekar, Rita P. Loudermilk, Yile Dai, Feimei Liu, Sara Sunshine, Jamin Liu, Wesley Wu, Isobel A. Hawes, Bonny D. Alvarenga, Trung Huynh, Lindsay McAlpine, Nur-Taz Rahman, Bertie Geng, Jennifer...
  10. Hutan

    Neutrophil Extracellular Traps

    Neutrophil Extracellular Traps (NETs) are potentially of interest to us. This image from a 2020 paper by a Chinese team (Neutrophil Extracellular Traps: Signaling Properties and Disease Relevance Tiewei Li, Zhengyan Zhang, Xiaojuan Li, Geng Dong, Min Zhang, Zhe Xu, and Junmei Yang) gives a feel...
  11. leokitten

    Sustained cellular immune dysregulation in individuals recovering from SARS-CoV-2 infection. Files et al. JCI (2020)

    https://www.jci.org/articles/view/140491 ScienceDaily News piece on paper here Of particular interest to long COVID research is they found immune dysregulation in non-hospitalized patients didn’t resolve quickly as well as activation and exhaustion markers increased during the...
  12. M

    The antinuclear antibody dense fine speckled pattern & possible clinical associations: indicates a proinflammatory environment, 2020, Lundgren et al

    The antinuclear antibody dense fine speckled pattern and possible clinical associations: An indication of a proinflammatory microenvironment (2020) Lundgren et al Abstract Background: Indirect immunofluorescence (IIF) is the most prevalent screening antinuclear antibody test for systemic...
    • Milo
    • Thread
    • 2020 antinuclear antibodies autoantibodies dense fine speckled pattern immunology indirect immunofluorescence lundgren me/cfs paper usa
    • Replies: 3
    • Forum: ME/CFS research
  13. Andy

    Preprint: Type I interferon potentiates metabolic dysfunction, inflammation, and accelerated aging in mtDNA mutator mice, 2020, Lei et al

    Open access, https://www.biorxiv.org/content/10.1101/2020.09.22.308171v1.full-text
  14. Hutan

    Unravelling intracellular immune dysfunctions in CFS: interactions between protein kinase R, RNase L cleavage, elastase, 2008, Meeus et al

    Unravelling intracellular immune dysfunctions in chronic fatigue syndrome: interactions between protein kinase R activity, RNase L cleavage and elastase activity, and their clinical relevance Mira Meeus 1, Jo Nijs, Neil McGregor, Romain Meeusen, Guy De Schutter, Steven Truijen, Marc Frémont...
    • Hutan
    • Thread
    • de meirleir elastase immunology mcgregor me/cfs meeus pkr rnase symptoms
    • Replies: 2
    • Forum: ME/CFS research
  15. Andy

    Environmental, Neuro-immune, and Neuro-oxidative Stress Interactions in Chronic Fatigue Syndrome, 2020, Bjørklund et al

    Paywall, https://link.springer.com/article/10.1007/s12035-020-01939-w Sci hub, https://sci-hub.tw/10.1007/s12035-020-01939-w
    • Andy
    • Thread
    • 2020 bjorklund immunology me/cfs nitric oxide paper pkr review
    • Replies: 1
    • Forum: ME/CFS research
  16. John Mac

    Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Efficacy of Repeat Immunoadsorption. Tolle, Scheibenbogen et al. 2020

    https://www.mdpi.com/2077-0383/9/8/2443
    • John Mac
    • Thread
    • 2020 antibodies autoantibodies immunoadsorption immunology me/cfs paper plasmapheresis scheibenbogen treatment
    • Replies: 15
    • Forum: ME/CFS research
  17. Sly Saint

    A Unifying Hypothesis of the Pathophysiology of (ME/CFS): Recognitions from the finding of autoantibodies against ß2-adrenergic receptors: Wirth 2020

    Review: A Unifying Hypothesis of the Pathophysiology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Recognitions from the finding of autoantibodies against ß2-adrenergic receptors KlausWirtha CarmenScheibenbogen...
    • Sly Saint
    • Thread
    • 2020 adrenergic receptors autoantibodies cerebral hypoperfusion immunology infection me/cfs paper pathophysiology scheibenbogen wirth
    • Replies: 25
    • Forum: ME/CFS research
  18. John Mac

    Chronic Fatigue Syndrome: Exercise Performance Related to Immune Dysfunction. Nijs et al. 2005

    https://www.medscape.com/viewarticle/516556 Edit: Title edited to reflect original year of study publication (2005 not 2020)
    • John Mac
    • Thread
    • cpet elastase exercise immunology me/cfs nijs nitric oxide pkr
    • Replies: 3
    • Forum: ME/CFS research
  19. Sly Saint

    A potential antigenic mimicry between viral and human proteins linking (ME/CFS) with autoimmunity:The case of HPV immunization - Phelan Feb 2020

    A potential antigenic mimicry between viral and human proteins linking Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) with autoimmunity: The case of HPV immunization Journal pre-proof https://www.sciencedirect.com/science/article/abs/pii/S1568997220300355 " This is a PDF file of...
    • Sly Saint
    • Thread
    • 2020 antigenic mimicry autoimmunity hpv immunology me/cfs paper phelan vaccination
    • Replies: 3
    • Forum: ME/CFS research
  20. Sly Saint

    Lowered Serum Cesium Levels in Schizophrenia: Association with Immune-Inflammatory Biomarkers and Cognitive Impairments: Almulla et al - Feb 2020

    https://www.preprints.org/manuscript/202002.0175/v1
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