calcium channels

Host Calcium Channels and Pumps in Viral Infections Xingjuan Chen,1,2 Ruiyuan Cao,2,* and Wu Zhong2,* Ca2+ is essential for virus entry, viral gene replication, virion maturation, and release. The alteration of host cells Ca2+ homeostasis is one of the strategies that viruses use to modulate...

SARS-CoV-2 spike protein receptor-binding domain perturbates intracellular calcium homeostasis and impairs pulmonary vascular endothelial cells Yang, Kai; Liu, Shiyun; Yan, Han; Lu, Wenju; Shan, Xiaoqian; Chen, Haixia; Bao, Changlei; Feng, Huazhuo; Liao, Jing; Liang, Shuxin; Xu, Lei; Tang...

Abstract: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a disabling multisystemic condition. The pathomechanism of ME/CFS remains unestablished; however, impaired natural killer (NK) cell cytotoxicity is a consistent feature of this condition. Calcium (Ca2+) is crucial for NK...

Abstract Background Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a serious disorder of unknown aetiology. While the pathomechanism of ME/CFS remains elusive, reduced natural killer (NK) cell cytotoxic function is a consistent immunological feature. NK cell effector functions...

From: Dr. Marc-Alexander Fluks Source: Analytica Chimica Acta Preprint Date: May 25, 2021 URL: https://www.sciencedirect.com/science/article/abs/pii/S0003267021005043 Broadband electrical impedance as a novel characterization of oxidative stress in single L6 skeletal muscle cells...

Split thread from Genome-wide association study identifies RNF123 locus as associated with chronic widespread musculoskeletal pain, Md Shafiqur Rahman, et al, 2020 *** I was reading about calcium channels the other day. This reference about them is very readable and interesting. Don't be put...

"Naltrexone restores impaired transient receptor potential melastatin 3 ion channel function in natural killer cells from myalgic encephalomyelitis/chronic fatigue syndrome patients" https://www.frontiersin.org/articles/10.3389/fimmu.2019.02545/abstract (No full text yet.)

Open access at https://molmed.biomedcentral.com/articles/10.1186/s10020-019-0083-4

An interesting correlation between use of these medications and reduced symptoms in a large scale study. One proposed mechanism is a reduction in inflammation. Neuroscience News : https://neurosciencenews.com/statins-mental-health-10473/ SMC reaction ...

Your disease is real: Breakthrough in diagnosis of chronic fatigue syndrome Researchers found chronic fatigue syndrome and the related myalgic encephalomyelitis, or ME, is a calcium ion channel impairment condition. For those who are living with ME/CFS, the announcement proves the disease is...

https://www.ncbi.nlm.nih.gov/pubmed/30134818 https://molmed.biomedcentral.com/articles/10.1186/s10020-018-0046-1

Paywalled at https://www.medical-hypotheses.com/article/S0306-9877(18)30364-5/fulltext

" Brief notes on Nimodipine and ME/CFS Nimodipine belongs to a group of drugs called calcium-channel blockers. In very simple terms these drugs relax the smooth muscle in the walls of blood vessels and cause them to dilate. So they are mainly used to lower blood pressure, treat angina, and...