Your disease is real: Breakthrough in diagnosis of chronic fatigue syndrome Researchers found chronic fatigue syndrome and the related myalgic encephalomyelitis, or ME, is a calcium ion channel impairment condition. For those who are living with ME/CFS, the announcement proves the disease is not a physiological or a psychological condition - it's real. Professor Don Staines, a clinical professor from Griffith University's National Centre for Neuroimmunology and Emerging Diseases (NCNED), said the findings were a "watershed moment". "We've demonstrated there are impairments in a particular group of calcium ion channels, and this causes impaired entry of calcium ions into the cell," he told Hack. In simpler terms, this means there is a lack of calcium in the cells and in the cells ion channels, which affects their ability to function properly.