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How chronic administration of benzodiazepines leads to unexplained chronic illnesses: A hypothesis, 2018, LaCorte

Discussion in 'BioMedical ME/CFS Research' started by Andy, Jul 28, 2018.

  1. Andy

    Andy Committee Member & Outreach

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    Paywalled at https://www.medical-hypotheses.com/article/S0306-9877(18)30364-5/fulltext
     
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  2. Esther12

    Esther12 Senior Member (Voting Rights)

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    I'm sure there was some internet commenter who used to talk a lot about 'the NO/ONOO(−) cycle' being important in ME/CFS, but it was never clear if they really had any evidence to support this, and it's not a claim I normally see in papers.

    Pretty sure I've been free of benzodiazepines anyway!
     
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  3. Little Bluestem

    Little Bluestem Senior Member (Voting Rights)

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    My doctor recommended that I get off of benzodiazepines some time ago. I'll write more about it 'someday'.
     
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  4. JaimeS

    JaimeS Senior Member (Voting Rights)

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    Maes/Morris, wasn't it? [Edit: Nope, sorry -- Dr Pall.]

    Ditto. Never taken 'em in my life.
     
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  5. ivorin

    ivorin Established Member (Voting Rights)

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    Well this certainly makes me feel a bit worried. Been taking them for 18 months now, they are the only thing helping me since my illness got severe. Guess it can always get more severe. FML
     
  6. Esther12

    Esther12 Senior Member (Voting Rights)

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    I wouldn't worry about it just on the basis of this paper (although all drugs can have side-effects it's worth being aware of).
     
    Last edited: Aug 2, 2018
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  7. Rossy191276

    Rossy191276 Established Member (Voting Rights)

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    I was just about to start taking clonazapem again because it is the only drug I have found helpful throughout my time with illness. In searching for a possible reason I discovered that GABA downregulates T cells which I thought was very interesting given the Mark Davis research into clonal T cell expansion.
     
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