autoantibodies

Severe COVID-19 induces autoantibodies against angiotensin II that correlate with blood pressure dysregulation and disease severity Briquez PS, Rouhani SJ, Yu J, Pyzer AR, Trujillo J, Dugan HL, Stamper CT, Changrob S, Sperling AI, Wilson PC, Gajewski TF, Hubbell JA, Swartz MA Patients infected...

Most patients with Post COVID Syndrome (PCS) present with a plethora of symptoms without clear evidence of organ dysfunction. A subset of them fulfills diagnostic criteria of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Symptom severity of ME/CFS correlates with natural...

Abstract Background Autoimmunity has been reported in patients with severe COVID-19. We investigated whether antinuclear/extractable-nuclear antibodies (ANAs) were present up to a year after infection, and if they were associated with the development of clinically relevant Post-Acute Sequalae...

Summary Background Understanding how SARS-CoV-2 affects respiratory centres in the brainstem may help to preclude assisted ventilation for patients in intensive care setting. Viral invasion appears unlikely, although autoimmunity has been implicated, the responsible antigens remain unknown. We...

https://www.sciencedirect.com/science/article/pii/S0889159115300209?via%3Dihub Open Access Madlen Loebel 1, Patricia Grabowski 2, Harald Heidecke 3, Sandra Bauer 2, Leif G Hanitsch 2, Kirsten Wittke 2, Christian Meisel 4, Petra Reinke 5, Hans-Dieter Volk 6, Øystein Fluge 7, Olav Mella 8, Carmen...

Detection of G Protein-Coupled Receptor Autoantibodies in Postural Orthostatic Tachycardia Syndrome Using Standard Methodology (the title is a bit misleading, read the whole abstract) Main author is Dr Satish Raj from Calgary. Abstract Background: Postural orthostatic tachycardia syndrome...

Platelet Storage Pool Deficiency and Elevated Inflammatory Biomarkers Are Prevalent in Postural Orthostatic Tachycardia Syndrome by William T. Gunning, Paula M. Kramer, Jacob A. Cichock, Beverly L. Karabin, Sadik A. Khuder, Blair P. Grubb doi.org/10.3390/cells11050774...

Abstract Purpose Previous studies demonstrated M2 muscarinic acetylcholine receptor-activating autoantibodies (M2R-AAb) were present in some patients with postural tachycardia syndrome (POTS). This study examines how these autoantibodies might contribute to the pathophysiology of POTS, and...

Highlights Longitudinal multiomics associate PASC with autoantibodies, viremia and comorbidities Reactivation of latent viruses during initial infection may contribute to PASC Subclinical autoantibodies negatively correlate with anti-SARS-CoV-2 antibodies Gastrointestinal PASC uniquely present...

vvv Source: Medical Immunology Vol 23, #4, pp 975-980 Date: July/August 2021 URL: https://www.mimmun.ru/mimmun/article/view/2439 https://www.mimmun.ru/mimmun/article/view/2439/1456 Early diagnostics of autoinflammatory disorders associated with post-viral chronic fatigue...

Abstract Background Activation of the immune system is implicated in the Post-Acute Sequelae after SARS-CoV-2 infection (PASC) but the mechanisms remain unknown. Angiotensin-converting enzyme 2 (ACE2) cleaves angiotensin II (Ang II) resulting in decreased activation of the AT1 receptor and...

https://pubmed.ncbi.nlm.nih.gov/34484936/ Abstract Objective: Postural tachycardia syndrome (POTS), the most common form of dysautonomia, may be associated with autoimmunity in some cases. Autoantibodies against the ganglionic acetylcholine receptor (gAChR) have been reported in a minority of...

Abstract Functional autoantibodies directed to the M2 muscarinic acetylcholine receptor (M2R) could affect the heart rate directly by altering cardiac M2R activity and/or indirectly by changing vagal-mediated cardiac M2R activity. We measured M2R autoantibody activity in sera from 10 subjects...

Full title: Neutralization of Autoantibodies Targeting G-Protein Coupled Receptors Improves Capillary Impairment and Fatigue Symptoms after COVID-19 Infection Abstract Clinical features of Corona Virus Disease 2019 (COVID-19) are caused by the severe acute respiratory syndrome coronavirus-2...

Autoantibodies to Vasoregulative G-Protein-Coupled Receptors Correlate with Symptom Severity, Autonomic Dysfunction and Disability in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Scheibenbogen et al Abstract Background: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is an...

Abstract Context Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a severe chronic illness which reduces the quality of life. A potential role of neuroendocrine autoimmune dysfunction has been hypothesized. Objective To investigate the occurrence of anti-pituitary (APA) and...

Autoantibody helps with Long Covid The German article https://www.fau.de/2021/07/news/medikament-gegen-autoantikoerper-hilft-bei-long-covid/ The paper is most interesting because of microcirculation, plus the use of BC 007, originally a heart related drug, as a treatment...

Nature - molecular psychiatry Chronic post-COVID-19 syndrome and chronic fatigue syndrome: Is there a role for extracorporeal apheresis? - Bornstein et al Abstract As millions of patients have been infected by SARS-CoV-2 virus a vast number of individuals complain about continuing...

I personally believe that ME/CFS is antibody driven and I therefore think this breakthrough technology could tell us alot about at least a subset of patients. Here you can identify antibodies to extracelluar proteins (non tissue degenerating) which relates to us as patients since there is no...

Touches on ME/CFS