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Early diagnostics of autoinflammatory disorders associated with post-viral CFS and cognitive impairments in chronic ... herpes, 2021, Nesterova et al

Discussion in 'ME/CFS research' started by Samuel, Nov 7, 2021.

  1. Samuel

    Samuel Senior Member (Voting Rights)

    Source: Medical Immunology
    Vol 23, #4, pp 975-980
    Date: July/August 2021
    URL: https://www.mimmun.ru/mimmun/article/view/2439

    Early diagnostics of autoinflammatory disorders associated
    with post-viral chronic fatigue syndrome and cognitive
    impairments in chronic mixed herpes viral infections
    Nesterova I.V(a), Khalturina E.O(b,*)
    a Peoples' Friendship University of Russia, Moscow, Russian
    b I. Sechenov First Moscow State Medical University (Sechenov
    University), Moscow, Russian Federation
    * Corresponding author: Khalturina Eugenia O.I. Sechenov First
    Moscow State Medical University 117452, Russian Federation,
    Moscow, Mochovaya, 11, bild.10. Phone: 7 (916) 650-15-14.
    E-mail: jane_k@inbox.ru

    Received 22.03.2021
    Revision received 02.06.2021
    Accepted 15.06.2021


    The steady increase in the number of autoimmune diseases and immune-mediated auto inflammatory processes causes an increased interest of doctors of all specialties in this topic and makes the issue of early detection of autoimmune disorders/autoimmune syndrome (AS) extremely urgent. These disorders often develop against the backdrop of an atypical stream of chronic active viral infections caused by persistent viruses, in particular those of the Herpesviridae family, and remain undiagnosed due to polysymptomatic disease, and various 'clinical masks' of the disorders caused by them. The semi-quantitative method developed by us for screening assessment of the content of autoantibodies in the blood serum of patients suffering from ACAI caused by herpes viruses using the ELISA method (Immunodot) is a highly specific screening method that can allow for an objective assessment of the dynamics of the autoimmune process, as well as control the effectiveness of the ongoing complex antiviral and immunomodulatory therapy. The detection of autoantibodies of various specificity in the blood serum of patients suffering from an atypical chronic active infection caused by herpes viruses (ACAI) is an early diagnostic marker, necessary, first of all, to identify autoimmune pathology of the nervous system, which is associated with a long course of the active mixed herpes-viral process.

    Keywords: herpesviruses, autoantibodies, gangliosides, autoimmunity, immune dysfunction, post-viral chronic fatigue syndrom

    from m-a fluks, public
    Skycloud, boolybooly, Yessica and 6 others like this.
  2. Ash

    Ash Senior Member (Voting Rights)

    A study still in progress?
    Hutan, Samuel and DokaGirl like this.
  3. Arnie Pye

    Arnie Pye Senior Member (Voting Rights)

    I haven't noticed an increase in interest in any of the medical conditions that I have ever presented to doctors with. Obviously I get sick in the wrong way.
    Skycloud, boolybooly, tmrw and 6 others like this.
  4. Ash

    Ash Senior Member (Voting Rights)


    They do like to say some things don’t they. Get some words in that paper.
    alktipping, Trish and Arnie Pye like this.
  5. Woolie

    Woolie Senior Member

    Bummer, its all in Russian!
    Ash, Samuel and alktipping like this.
  6. Hutan

    Hutan Moderator Staff Member

    Aotearoa New Zealand
    There is an English version. click on the first link and look for ENG(PDF)

    It's one of those ones where you wonder if there is a kernel of something important hidden by the very poor presentation and missing information.
    boolybooly, Yessica, Ash and 2 others like this.
  7. Hutan

    Hutan Moderator Staff Member

    Aotearoa New Zealand
    They had 20 controls and 20 patients. The patients were highly highly selected, in particular having many infections including recurrent herpes outbreaks:
    It's a bit hard to know what they found in terms of autoantibodies. But they seemed to find a lot of autoantibodies to gangliosides. I don't think they tell us what they found in the controls.

    They give us a categorisation of the level of the autoantibodies (low, high, etc), but they don't actually report what levels were found.

    Screen Shot 2021-11-08 at 3.20.39 PM.png

    Screen Shot 2021-11-08 at 3.23.02 PM.png

    So, as much as I would like the answer to ME/CFS to be an autoantibody, I'm left skeptical and confused.
    Last edited: Nov 8, 2021
    Skycloud, shak8, cfsandmore and 5 others like this.
  8. boolybooly

    boolybooly Senior Member (Voting Rights)

    This is the first paper I have seen with patient cohort criteria which match my own condition.

    ACAI (atypical chronic active infection) caused by mixed HVIs (herpes virus infections) is exactly what I have (EBV + HSV2).

    The medics I have seen in the UK do not acknowledge this condition exists.
    Last edited: Nov 20, 2021
    Samuel and Skycloud like this.

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