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New Baraniuk paper on CSF after exercise looks to be coming out

Discussion in 'BioMedical ME/CFS News' started by Jonathan Edwards, Nov 9, 2017.

  1. Jonathan Edwards

    Jonathan Edwards Senior Member (Voting Rights)

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    Does anybody know what this is about?

    Brain chemistry study shows chronic fatigue syndrome, Gulf War illness as unique disorders
    Eurekalert science news

    Was sent by a friendly journalist.

    I cannot seem to access it.
     
  2. Esther12

    Esther12 Senior Member (Voting Rights)

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    If sent by a journalist, maybe it's currently under embargo?
     
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  3. adreno

    adreno Senior Member (Voting Rights)

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    This part of the URL would suggest so:

    emb_releases
     
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  4. Jonathan Edwards

    Jonathan Edwards Senior Member (Voting Rights)

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    You mean he's winding me up?!!!
     
  5. Esther12

    Esther12 Senior Member (Voting Rights)

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    If he's logged in, he may not have realised that you need a journalist's log in details to access the link.
     
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  6. Jonathan Edwards

    Jonathan Edwards Senior Member (Voting Rights)

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    It seems to be a new paper from James Baraniuk - looks interesting. I am trying to find out if I am allowed to say anything public.
     
  7. Jonathan Edwards

    Jonathan Edwards Senior Member (Voting Rights)

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    Apparently it is under embargo maybe until tomorrow so keep an eye out chaps.
    James Baraniuk has been looking at CSF after exercise in CFS and his two types of Gulf War Illness and may be finding something interesting. I think James is about the best scientist we have a present so I am hoping this will be something to get our teeth into.
     
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  8. Esther12

    Esther12 Senior Member (Voting Rights)

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  9. Barry

    Barry Senior Member (Voting Rights)

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    I would think that is much more likely. It's very easy to lose sight of who does and doesn't have access to web/network locations, if it is an area you have access all the time.
     
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  10. Barry

    Barry Senior Member (Voting Rights)

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    Very nice. As our shiny new forum gets up to speed, it will be good to get stuck into what we are really about.
     
  11. Sasha

    Sasha Senior Member (Voting Rights)

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  12. BurnA

    BurnA Senior Member (Voting Rights)

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    He spoke at iimec 11 (2016)

    Here is what @Mark wrote about it



     
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  13. Kalliope

    Kalliope Established Member (Voting Rights)

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  14. Jonathan Edwards

    Jonathan Edwards Senior Member (Voting Rights)

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    James is not a prima donna. He gets on with the work and is prepared to address the difficult questions.

    Remember it was James who re-wrote the BMJ clinical guidelines.

    Within the research community he is recognised as the wise owl.
     
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  15. Lidia

    Lidia Established Member

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    And so witty! I have a little crush after reading @Mark’s coverage.
     
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  16. Sasha

    Sasha Senior Member (Voting Rights)

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  17. Kalliope

    Kalliope Established Member (Voting Rights)

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  18. Adrian

    Adrian Senior Member (Voting Rights)

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    From the press release
    So it looks like a before and after exertion study which I think is exactly what we need in terms of ME and understanding the dynamics of the illness. It maybe that tests require this rather than a static snapshot.

     
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  19. Trish

    Trish Senior Member (Voting Rights)

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    This looks like the paper. I have split it into short paragraphs for ease of reading.

    https://www.nature.com/articles/s41598-017-15383-9

    Exercise – induced changes in cerebrospinal fluid miRNAs in Gulf War Illness, Chronic Fatigue Syndrome and sedentary control subjects
    Received:
    07 February 2017
    Accepted:
    11 October 2017
    Published online:
    10 November 2017
    Abstract


    Gulf War Illness (GWI) and Chronic Fatigue Syndrome (CFS) have similar profiles of pain, fatigue, cognitive dysfunction and exertional exhaustion.

    Post-exertional malaise suggests exercise alters central nervous system functions. Lumbar punctures were performed in GWI, CFS and control subjects after (i) overnight rest (nonexercise) or (ii) submaximal bicycle exercise.

    Exercise induced postural tachycardia in one third of GWI subjects (Stress Test Activated Reversible Tachycardia, START).

    The remainder were Stress Test Originated Phantom Perception (STOPP) subjects. MicroRNAs (miRNA) in cerebrospinal fluid were amplified by quantitative PCR.

    Levels were equivalent between nonexercise GWI (n = 22), CFS (n = 43) and control (n = 22) groups.

    After exercise, START (n = 22) had significantly lower miR-22-3p than control (n = 15) and STOPP (n = 42), but higher miR-9-3p than STOPP.

    All post-exercise groups had significantly reduced miR-328 and miR-608 compared to nonexercise groups; these may be markers of exercise effects on the brain.

    Six miRNAs were significantly elevated and 12 diminished in post-exercise START, STOPP and control compared to nonexercise groups.

    CFS had 12 diminished miRNAs after exercise.

    Despite symptom overlap of CFS, GWI and other illnesses in their differential diagnosis, exercise-induced miRNA patterns in cerebrospinal fluid indicated distinct mechanisms for post-exertional malaise in CFS and START and STOPPphenotypes of GWI.
     
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  20. Sasha

    Sasha Senior Member (Voting Rights)

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    I think this needs a new thread from post #17, with the title of the paper as the thread title.

    I'm reporting my own post, to ask the mods to split the thread.
     
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