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You're getting a bit technical here, @Sasha. This is what imputation protocols are for.God knows how they work. Sometimes, sometimes not. For instance, in the MHC you have Class I genes at one end, whose proteins bind to CD8 T cells, and Class II genes at the other, whose genes bind to CD4 T...

In clinical severity terms I do not see any doubt that axial spondarthritis is a bigger problem in men. non-radiographic spondathritis seems to me a concept begging to be a political football and not much else. Any way these are not autoimmune diseases so the whole piece is pushing a phoney...

I don't think the government wants to cut this sort of thing. Mr Starmer is very keen for everyone to be able to see a physio at once without messing about with waiting for doctors and to do it in a shed in your neighbourhood rather than a hospital. That will prevent cancer, heart disease...

Yes but ankylosing spondylitis and psoriatic arthritis are not autoimmune diseases and not more common in women.

No you're not @Sasha. This is clearly a biased choice, based on your pet theory!! Now you have started you can continue but you also need to pick another three genes that are complete gobbledygook and drive yourself nuts trying to figure those ones out.

I think if we have done nothing else in the last ten years it is to have established that beyond doubt.

Except that the great thing about gene linkages is that they are always the root cause. It is just that they are part of the root cause and the root cause is the entire organism, its evolutionary history and its entire environment. As Leibniz pointed out the cause of an event is everything...

We listed the genes on the Zhang thread somewhere. It is worth having a go but remember that this is a bit like staring at a faded fragment of parchment and trying to work out whether the Bhagavad Gita was influenced by the Aryan Invasion. The Gene card may give you a rough date for the...

It probably does but I am sceptical that computer modelling is ever needed or is ever likely to work for the complete picture, for reasons in the last post. Our qualitative model allowed us to make a breakthrough in treatment that has led on to healthcare interventions valued at roughly Bill...

As @jnmaciuch says, this isn't really the case. We are taught about the central role of feedback loops as first year students. Homeostasis is central to all biology and amplification positive loops are well understood. When I worked out a pathway for antibody involvement in rheumatoid we had a...

Mast cells carry Fc gamma R1 !!

I don't know enough about data on antibody profiles with Dara. I am not sure what the reason for 24 and 48 weeks would be. These are relevant to rituximab because it takes approximately 24 weeks for B cell recovery but that is not relevant to plasma cell targeting where the recovery in antibody...

It will be. That is what the project is on - current existing models. This is always what NIHR was for - to window dress politically convenient aspects of service.

I keep coming back to the case of cataplexy and its relation to REM sleep paralysis. In sleep paralysis we feel it is the leg muscles that will not work, trying to run away from danger. Respiratory muscles are excluded from cataplexy and REM paralysis. Cataplexy switches on and off without...

And the government thinks this is a jewel in the crown of the 'plan'? How do you explore the effectiveness of healthcare models without trials? This is the pits.

This looks like a load of dangerous horse ####. That sort of presentation could well be a transient ischaemic episode. The idea that the brain can concoct memory loss in some 'functional' way is as far as i can see pure fairy tale. People do not 'do things subconsciously'. This is just the fag...

I don't think Leng was the reason for a good pitch in 2019. She was handed the baton with the weightings already in place. I think the RCP tried to row back but Peter Barry and Ilora Finlay were clear about their job specification - get the right result if you can.

Why not as the Pompous Parsnip AI what successful brainstorming would look like?

This looks well-informed and balanced. There may still be a lack of appreciation that to the government 'in the community' just means cheap, cheerful and what sounds nice. But otherwise it is very fair.

I think last time several years of preparatory work had established a favourable atmosphere in the NICE chairman's office. That might not apply now.