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UK Health Research Authority defends PACE. Answer to MP's question, February 2019.

Discussion in 'PsychoSocial ME/CFS Research' started by Michiel Tack, Feb 6, 2019.

  1. Michiel Tack

    Michiel Tack Senior Member (Voting Rights)

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    This thread has been split from the general thread on the PACE trial.

    The Health Research authority has responded to questions of MP Norman Lamb from the Science and Technology Committee, House of Commons, regarding the PACE-trial. https://www.parliament.uk/documents...Research-Authority-to-Chair-re-PACE-trial.pdf

    The HRA defends the PACE-trial and does not see anything wrong with it.
    The Science media Center is promoting the letter, with expert reactions to the letter. http://www.sciencemediacentre.org/e...iry-on-research-integrity-and-the-pace-trial/
     
    Last edited by a moderator: Feb 6, 2019
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  2. Cheshire

    Cheshire Moderator Staff Member

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    Michael Sharpe makes it look like PACE has been totally cleared:

    When the report says:

     
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  3. Cheshire

    Cheshire Moderator Staff Member

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    From the HRA document

    But they found that:
    How did they arrive to this conclusion?
    :jawdrop:

    And so?

    WTF
     
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  4. Cheshire

    Cheshire Moderator Staff Member

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    They nonetheless investigated 3 separate issues.

    Conflicts of Interest

    Availability of data for secondary analysis

    Alterations in the outcome measures used

    :sick:
     
  5. Barry

    Barry Senior Member (Voting Rights)

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    "However, the full picture shows that the general approach was to release data responsibility."

    What data was that then?
     
  6. NelliePledge

    NelliePledge Senior Member (Voting Rights)

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    Anyone else think SMC are trying to be clever by getting quote from a Prof from LSHTM
     
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  7. Esther12

    Esther12 Senior Member (Voting Rights)

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    This report seems to be a mix of confusion about what the criticisms made of PACE were and a presumption that if other supposedly authoritative sources said things were okay, they were okay. They don't provide any new information at all.
     
  8. NelliePledge

    NelliePledge Senior Member (Voting Rights)

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    Establishment digging their heels in - they are embarrassing
     
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  9. dave30th

    dave30th Senior Member (Voting Rights)

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    what does "the supplement of the categorical outcome scores by measures of improvement" mean? what is that referring to? The post-hoc "improvement" findings?
     
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  10. Binkie4

    Binkie4 Senior Member (Voting Rights)

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  11. rvallee

    rvallee Senior Member (Voting Rights)

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    You just have to laugh at the fact that they cite NICE recommending the "treatments" as independent validation of the promise they held at the time when of course this recommendation came from their own work and Wessely's influence.

    Literally pointing at their own recommendation as evidence that it was recommended.

    According to me, I should receive the Nobel peace prize. I even have a good and proper recommendation: me. Thank me, that clever rascal. I also approve of me nominating myself and voting myself. And, oh would you look at that I can now confirm independent recommendation of my perfection and you just know it is true and perfect because I approve of it.

    Also according to my mirror: I am a thing a beauty. My mirror told me independently and I can vouch for it.
     
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  12. Esther12

    Esther12 Senior Member (Voting Rights)

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  13. Cheshire

    Cheshire Moderator Staff Member

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  14. Adrian

    Adrian Administrator

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    Since PACE hasn't published all the secondary outcomes as defined in the protocol (although patients published the recovery one) the HRA don't have high expectations over transparency.
     
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  15. Adrian

    Adrian Administrator

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    So they basically reflect back to their only defense PACE is ok because Cochrane say its ok.
     
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  16. strategist

    strategist Senior Member (Voting Rights)

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    This agency does not appear to have performed an independent analysis and was apparently deceived by the carefully crafted illusion that PACE is OK.

    That people who look only superficially into PACE conclude that there aren't major problems has happened before. A forensic analysis is required.

    For example, the classification of PACE as having low risk of bias by Cochrane violated Cochrane's own rules for assessing bias in clinical trials. The data sharing with Cochrane is also not what it appears, as the PACE authors themselves were part of the review team. Prof. Chalder even admitted that this was not an independent review. They have never released the data to independent scientists as far as I know (or at least not to scientists that were critical).
     
    Last edited: Feb 6, 2019
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  17. large donner

    large donner Senior Member (Voting Rights)

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    Its rather confusing, which PACE study do they think carries the real results? The revised protocol study where they claimed modest recovery rates or the original protocol that didn't change the definition of recovery to being ill and recovered at the same time which allowed the revised definition to claim the modest efficacy rates rather than showing the facts that there was zero clinically statistical significance to the treatments?

    Or is such like out side of the scope of their investigation in which case what exactly did they look into?
     
  18. Robert 1973

    Robert 1973 Senior Member (Voting Rights)

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    HRA only concluded (wrongly IMO) that there are no major concerns within its regulatory remit:
     
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  19. dave30th

    dave30th Senior Member (Voting Rights)

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    I think in any response the limits of their remit must be emphasized. Although I agree that even within their remit this analysis falls short.
     
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  20. Andy

    Andy Committee Member & Outreach

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    Do you think they really mean this?
    Surely they intended to say
     
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