You may have heard of it? At the other place, some of us wrote a word or two about it. I thought it might be good to have a thread for PACE chats, or for new people to ask questions, that didn't necessarily relate to important new papers, or anything that warranted a new thread. I could post some summaries of PACE issues into this first post. Criticism: Links to David Tuller's work on the PACE trial are being linked to from this page: http://me-pedia.org/wiki/David_Tuller Tuller's compendium on Virology is currently up to date, but has been less consistently updated than his me-pedia pages: http://www.virology.ws/mecfs/ Rebecca Goldin from Sense About Statistics criticised PACE here: http://www.stats.org/pace-research-sparked-patient-rebellion-challenged-medicine/ The Special Edition of the Journal of Health Psychology, devoted to PACE, is available here: http://journals.sagepub.com/toc/hpqa/22/9 Julie Rehmeyer's piece on the PACE recovery re-anaylsis is here: https://www.statnews.com/2016/09/21/chronic-fatigue-syndrome-pace-trial/ Pre-print of "Rethinking the treatment of chronic fatigue syndrome—A reanalysis and evaluation of findings from a recent major trial of graded exercise and CBT" by Wilshire et al.: https://www.researchgate.net/public...recent_major_trial_of_graded_exercise_and_CBT And the thread discussing it: https://www.s4me.info/threads/rethi...-major-trial-of-graded-exercise-and-cbt.2282/ Some historical pieces: 2011 summary of PACE concerns: "Methodological Inconsistencies in the PACE trial for ME/CFS" by Tate Mitchell Here's a plain text version ( with graphs linked to at the end): https://listserv.nodak.edu/cgi-bin/wa.exe?A2=ind1112A&L=CO-CURE&P=R540&I=-3 Section 6 of this focusses on the PACE trial: Kindlon T. Reporting of Harms Associated with Graded Exercise Therapy and Cognitive Behavioural Therapy in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. Bulletin of the IACFS/ME. 2011;19(2):59-111. http://iacfsme.org/PDFS/Reporting-of-Harms-Associated-with-GET-and-CBT-in.aspx Critical letters sent about the PACE recovery paper: http://www.meassociation.org.uk/201...ournal-of-psychological-medicine-august-2013/ (Most of the main) PACE papers: Whoops, just noticed Woolie already has a thread on this in the Research Library: https://www.s4me.info/index.php?threads/publications-from-the-pace-trial.60/ 2007 Published protocol: White PD, Sharpe MC, Chalder T, DeCesare JC, Walwyn R; PACE trial group. Protocol for the PACE trial: a randomised controlled trial of adaptive pacing, cognitive behaviour therapy, and graded exercise, as supplements to standardised specialist medical care versus standardised specialist medical care alone for patients with the chronic fatigue syndrome/myalgic encephalomyelitis or encephalopathy. BMC Neurol. 2007; 7:6. http://www.biomedcentral.com/1471-2377/7/6 2011 Main PACE trial paper: White PD, Goldsmith KA, Johnson AL, Potts L, Walwyn R, DeCesare JC, Baber HL, Burgess M, Clark LV, Cox DL, Bavinton J, Angus BJ, Murphy G, Murphy M, O'Dowd H, Wilks D, McCrone P, Chalder T, Sharpe M; PACE trial management group. Comparison of adaptive pacing therapy, cognitive behaviour therapy, graded exercise therapy, and specialist medical care for chronic fatigue syndrome (PACE): a randomised trial. Lancet. 2011; 377:823-36. http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(11)60096-2/abstract 2012 Cost-effectiveness analysis (Includes employment and welfare benefits data): McCrone P, Sharpe M, Chalder T, Knapp M, Johnson AL, Goldsmith KA, White PD. Adaptive pacing, cognitive behaviour therapy, graded exercise, and specialist medical care for chronic fatigue syndrome: A cost-effectiveness analysis. PLoS ONE 2012; 7:e40808. http://www.plosone.org/article/info:doi/10.1371/journal.pone.0040808 2013 [Alleged] "Recovery" paper: White PD, Johnson AL, Goldsmith K, Chalder T, Sharpe MC. Recovery from chronic fatigue syndrome after treatments given in the PACE trial. Psychological Medicine 2013; 43:2227-35. http://journals.cambridge.org/abstract_S0033291713000020 2013 Statistical Analysis Plan: Walwyn R, Potts L, McCrone P, Johnson AL, DeCesare JC, Baber H, Goldsmith K, Sharpe M, Chalder T, White PD. A randomised trial of adaptive pacing therapy, cognitive behaviour therapy, graded exercise, and specialist medical care for chronic fatigue syndrome (PACE): statistical analysis plan. Trials 2013; 14:386. http://www.trialsjournal.com/content/14/1/386 2014 Adverse events and deterioration: Dougall D, Johnson A, Goldsmith K, Sharpe M, Angus B, Chalder T, White P. Adverse events and deterioration reported by participants in the PACE trial of therapies for chronic fatigue syndrome. J Psychosom Res. 2014; 77:20-6. http://www.sciencedirect.com/science/article/pii/S0022399914001883 2015 Secondary Mediation Analysis (contains the step test results - graph only): Rehabilitative therapies for chronic fatigue syndrome: a secondary mediation analysis of the PACE trial. Chalder T, Goldsmith KA, White PD, Sharpe M, Pickles AR. Lancet Psychiatry 2015; 2:141–52 http://www.thelancet.com/journals/lanpsy/article/PIIS2215-0366(14)00069-8/abstract 2015 Two Year Follow Up: Sharpe M, Goldsmith KA, Johnson AL, Chalder T, Walker J, White PD. Rehabilitative treatments for chronic fatigue syndrome: long-term follow-up from the PACE trial. Lancet Psychiatry 2015; 2:1067–74 DOI: http://dx.doi.org/10.1016/S2215-0366(15)00317-X http://www.thelancet.com/journals/lanpsy/article/PIIS2215-0366(15)00317-X/fulltext 2015 Longitudinal Mediation Analysis - conference abstract only: Goldsmith K, Chalder T, White P, Sharpe M, Pickles A. Longitudinal mediation in the PACE randomised clinical trial of rehabilitative treatments for chronic fatigue syndrome: modelling and design considerations Trials 2015; 16(Suppl 2):O43 doi:10.1186/1745-6215-16-S2-O43 http://www.trialsjournal.com/content/16/S2/O43 ------------------------------------------------------------------------------------------------------ Minor papers and PACE-related papers: Lawn T, Kumar P, Knight B, Sharpe M, White PD. (2010) Psychiatric misdiagnoses in patients with chronic fatigue syndrome. JRSM Short Rep. 1:28. Cella M, Sharpe M, Chalder T. (2011) Measuring disability in patients with chronic fatigue syndrome: reliability and validity of the Work and Social Adjustment Scale. J Psychosom Res. 71:124-8. Cella M, White PD, Sharpe M, Chalder T. (2013) Cognitions, behaviours and co-morbid psychiatric diagnoses in patients with chronic fatigue syndrome. Psychological Medicine 43:375-380. doi:10.1017/S0033291712000979 Bourke JH, Johnson AL, Sharpe M, Chalder T, White PD. (2014) Pain in chronic fatigue syndrome; response to rehabilitative treatments in the PACE trial. Psychological Medicine 44:1545-52. doi:10.1017/S0033291713002201 Cox D, Burgess M, Chalder T, Sharpe M, White P, Clark L. (2013) Training, supervision and therapists' adherence to manual-based therapy. International Journal of Therapy and Rehabilitation 20:180-186. White PD, Chalder T, Sharpe M. (2015) The planning, implementation and publication of a complex intervention trial for chronic fatigue syndrome: the PACE trial. BJPsych Bull. 39:24-7. doi: 10.1192/pb.bp.113.045005 http://www.ncbi.nlm.nih.gov/pubmed/26191420 Lewith G, Stuart, Chalder T, McDermott C, White PD. (2016) Complementary and alternative healthcare use by participants in the PACE trial of treatments for chronic fatigue syndrome. J Psychosom Res. 2016 Aug;87:37-42. doi: 10.1016/j.jpsychores.2016.06.005. https://www.ncbi.nlm.nih.gov/pubmed/27411750 Williams TE, Chalder T, Sharpe M, White PD. (2017) Heterogeneity in chronic fatigue syndrome - empirically defined subgroups from the PACE trial. Psychol Med. 2017 Jun;47(8):1454-1465. doi: 10.1017/S0033291716003615. https://www.ncbi.nlm.nih.gov/pubmed/28112075 PS: I was planning to be more extensive... but there's so much criticism of PACE now I wanted to give up. Will add more in on request/later.