The micro-clot finding in Long Covid — implications for the possible aetiology of ME/CFS

hibiscuswahine said:
what are these fibrin amyloid particles actually doing?
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Absolutely. This is the diplodocus in the room! Radiolabelling and injecting processed particles might be problematic and otherwise we don't seem to know what to radiolabel, but I think it is simpler than that. If these clots were causing vascular changes they would be clinically apparent. They aren't.
 
Maybe just to put this in perspective. Covid has been with us for five years now. We have seen about six papers on indirect evidence for thrombotic phenomena in LC. There are 1,450 papers on thrombotic phenomena with Covid vaccines, where clinical evidence is now well recognised.
 
One interesting possibility is that the causation is the other way around. Maybe in LC there is persistent endothelial activation because of some after effect of the spike protein interaction with ACE-R. Maybe that makes people feel generally fatigued. And secondarily there is a reactive shift in coagulation proteins, that do not actually contribute anything to the clinical problem.
 
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