The IDO Metabolic Trap Hypothesis for the Etiology of ME/CFS 2019 Kashi, Davis, Phair.

beverlyhills said:
It does not have to be vaccines, even. In the 1960s, the majority of the population was getting Epstein Barr and Cytomegalovirus when they were 3 years old. In the 1980s this switched to adolescence.
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I wonder whether that is a general trend. There is amongst the various papers on the 1934 LA epidemic a comment that over the course of the previous two or three epidemics the average age of those affected had been increasing and the mortality decreasing.
 
Microbes continuously evolve that is change to gain most at least cost. Hosts can only change slowly so the effects of infection vary. That's why you can suddenly get an epidemic or outbreak.

Many disease are more dangerous in adults than children. It was thought that polio was a curse of the middle class because their children were not exposed at a young age.

There again, older adults may have been exposed before so the bug is changed enough to make them sick but not to kill them. Diptheria killed because it multiplied before the immune system kicked in. With some disease if you can survive long enough your immune system will save you.

It is immensely complicated.
 
Michiel Tack said:
I wonder if Robert Phair and his team are in contact with the Frenc researcher Gilles Guillemin. He has published quite a lot on the kynurenine pathway in other diseases (https://researchers.mq.edu.au/en/persons/gilles-guillemin/publications/) and seems to have taken an interest in ME/CFS as well (https://www.mq.edu.au/newsroom/2019...syndrome-research-receives-1-million-funding/)
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That would be absolutely awesome. I'm pleasantly surprised to see a French neurologist working on ME/CFS in collaboration with Paul Fisher's team (https://www.s4me.info/threads/an-is...me-cfs-patients-missailidis-et-al-2019.11121/) and a ME/CFS association -- that's a first!

Pr Jérôme Authier in France is part of EUROMENE but most of his research is centered on macrophagic myofasciitis. He has also publically dismissed Ron Davis & et al's nanoneedle as being, essentially, a commercial venture. Other than that, French neurologists usually deny the existence of ME/CFS.

ETA: From his list of publications, Gilles Guillemin seems to work on the potential neurotoxicity of vaccine adjuvants. So he probably knows Jérôme Authier quite (very) well. It would be great if he could get him involved into research on IDO2 & the kynurenine pathway in ME/CFS.
 
Michiel Tack said:
I didn't notice this: could you give an example?
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I might be wrong but aluminium and neurotoxicity ring a bell in the following publications:

Amelioration of aluminum maltolate-induced inflammation and endoplasmic reticulum stress-mediated apoptosis by tannoid principles of Emblica officinalis in neuronal cellular model
Dhivya Bharathi, M., Justin-Thenmozhi, A., Manivasagam, T., Ahmad Rather, M., Saravana Babu, C., Mohamed Essa, M. & Guillemin, G. J., 1 Feb 2019, In : Neurotoxicity Research. 35, 2, p. 318-330 13 p.

Asiatic acid attenuated aluminum chloride-induced tau pathology, oxidative stress and apoptosis via AKT/GSK-3β signaling pathway in Wistar rats
Ahmad Rather, M., Justin-Thenmozhi, A., Manivasagam, T., Saravanababu, C., Guillemin, G. J. & Essa, M. M., 15 May 2019, In : Neurotoxicity Research. 35, 4, p. 955-968 14 p.

Neuroprotective role of Asiatic acid in aluminium chloride induced rat model of Alzheimer's disease
Ahmad Rather, M., Justin Thenmozhi, A., Manivasagam, T., Dhivya Bharathi, M., Mohamed Essa, M. & Guillemin, G. J., 1 Jan 2018, In : Frontiers in bioscience (Scholar edition). 10, p. 262-275 14 p.

Fenugreek seed powder attenuated aluminum chloride-induced tau pathology, oxidative stress, and inflammation in a rat model of Alzheimer's disease
Prema, A., Justin Thenmozhi, A., Manivasagam, T., Mohamed Essa, M. & Guillemin, G. J., 2017, In : Journal of Alzheimer's Disease. 60, s1, p. S209-S220 12 p.
 
Michiel Tack said:
I wonder if Robert Phair and his team are in contact with the Frenc researcher Gilles Guillemin. He has published quite a lot on the kynurenine pathway in other diseases (https://researchers.mq.edu.au/en/persons/gilles-guillemin/publications/) and seems to have taken an interest in ME/CFS as well (https://www.mq.edu.au/newsroom/2019...syndrome-research-receives-1-million-funding/)
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cassava7 said:
ETA: From his list of publications, Gilles Guillemin seems to work on the potential neurotoxicity of vaccine adjuvants. So he probably knows Jérôme Authier quite (very) well. It would be great if he could get him involved into research on IDO2 & the kynurenine pathway in ME/CFS.
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As so often seems to be the way with ME/CFS researchers, clinicians and even high profile advocates, it seems that Gilles Guillemin may possibly not be someone we should pin our hopes on.

Sydney Herald 28 Dec 2021
Macquarie University is considering whether to investigate allegations of research misconduct after concerns were raised about more than 40 papers published by researchers at the Centre for Motor Neurone Disease Research that appeared to contain manipulated or duplicate images.

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They include neuroscientist Gilles Guillemin, whose name is attached to 25 articles that have been red-flagged for containing potentially doctored images on a research discussion website and scientist Bingyang Shi, who was a co-author of five papers where the journal has acknowledged errors post-publication.

An analysis of papers co-authored by researchers at the Centre for MND Research shows concerns have also been raised about at least 44 publications by members of that laboratory.

The French-born Professor Guillemin was awarded his AM during this year’s Queen’s Birthday Honours in recognition of his contribution to science education, motor neurone disease research and sport. He was nominated for the 2017 Eureka Prize for identifying a biomarker that discriminated between different types of multiple sclerosis.

Questions about his published research were initially asked by Dutch microbiologist Elisabeth Bik, a world leader in spotting duplicated images in scientific literature, who found unexpected similarities among the western blots, an analytical technique used in molecular biology. It appeared that the same images had been used to illustrate different findings.

In 2019, she raised concerns on PubPeer – a website where scientists discuss published research – about images contained in six papers co-authored by Professor Guillemin, prompting him to ask her whether her investigations were random or targeted. She said in reply that she was reviewing papers by one of his co-authors, who worked at a separate institution, while following dozens of leads across biomedical literature.

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Then in September this year, science blogger Leonid Schneider exposed more claims against Professor Guillemin after Dr Bik and other anonymous PubPeer reviewers identified unexpected similarities among images contained in a further 17 articles co-authored by him.
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Hutan said:
As so often seems to be the way with ME/CFS researchers, clinicians and even high profile advocates, it seems that Gilles Guillemin may possibly not be someone we should pin our hopes on.

Sydney Herald 28 Dec 2021
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Guillemin defended himself, saying:
Professor Guillemin acknowledged to The Sydney Morning Herald and The Age that some of the papers flagged on PubPeer to which his name was attached appeared to contain doctored images, but said he did not and has never doctored images. In each of the papers where genuine issues were identified, his role was confined to providing advice on the experiment design or scientific terms of the paper and not the experiments themselves, he said.
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And another scientist said:
A neuroscientist at a different university, who did not wish to be named to preserve his working relationships in the field, said the results of some of those papers had been reproduced by others in the field so he did not think the results had been falsified — only that corners had been cut.
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Although in a blog post that goes into more detail science journalist Leonid Schneider seems very unconvinced that Guillemin had no role in the alleged misconduct: https://forbetterscience.com/2021/09/07/none-of-the-work-has-not-been-done-in-my-lab/
 
cassava7 said:
That would be absolutely awesome. I'm pleasantly surprised to see a French neurologist working on ME/CFS in collaboration with Paul Fisher's team (https://www.s4me.info/threads/an-is...me-cfs-patients-missailidis-et-al-2019.11121/) and a ME/CFS association -- that's a first!

Pr Jérôme Authier in France is part of EUROMENE but most of his research is centered on macrophagic myofasciitis. He has also publically dismissed Ron Davis & et al's nanoneedle as being, essentially, a commercial venture. Other than that, French neurologists usually deny the existence of ME/CFS.

ETA: From his list of publications, Gilles Guillemin seems to work on the potential neurotoxicity of vaccine adjuvants. So he probably knows Jérôme Authier quite (very) well. It would be great if he could get him involved into research on IDO2 & the kynurenine pathway in ME/CFS.
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I haven't kept up but Jonas Bergquest, Upsala University, Sweden, got an OMF grant to look at Kynurenine. I'm impressed by Jonas/the analytical team he leads, so there are European based researchers who can contribute to ME/CFS research - they need funding - particularly via Horizon Europe (European Union research funding program).
 
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