1. Guest, the 'News in Brief' for the week beginning 31st May 2021 is here.
    Dismiss Notice
  2. Welcome! To read the Core Purpose and Values of our forum, click here.
    Dismiss Notice
  3. Contribute to feedback on the CDC Evidence Review, for more details click here
    Dismiss Notice

kynurenine

  1. Possibly James May
    Thread

    Phase 1 study to access safety, tolerability, pharmacokinetics, and pharmacodynamics of kynurenine in healthy volunteers, 2021, Al-Karagholi et al

    Abstract The kynurenine pathway (KP) is the main path for tryptophan metabolism, and it represents a multitude of potential sites for drug...
    Thread by: Possibly James May, Mar 23, 2021, 0 replies, in forum: Health News and Research unrelated to ME/CFS
  2. Andy
    Thread

    Inflammation control & improvement of cognitive function in COVID-19: is there a role for kynurenine 3-monooxygenase inhibition?, Collier et al, 2021

    Full title: Inflammation control and improvement of cognitive function in COVID-19 infections: is there a role for kynurenine 3-monooxygenase...
    Thread by: Andy, Feb 21, 2021, 0 replies, in forum: Epidemics (including Covid-19)
  3. Andy
    Thread

    Searching for Peripheral Biomarkers in Neurodegenerative Diseases: The Tryptophan-Kynurenine Metabolic Pathway, 2020, Torok et al

    Neurodegenerative diseases are multifactorial, initiated by a series of the causative complex which develops into a certain clinical picture. The...
    Thread by: Andy, Dec 12, 2020, 1 replies, in forum: Health News and Research unrelated to ME/CFS
  4. Theo
    Thread

    Evidence of Structural Protein Damage and Membrane Lipid Remodeling in Red Blood Cells from COVID-19 Patients, 2020, Thomas et al

    Both red blood cells damage and kynurine identified in LongCovid research...
    Thread by: Theo, Nov 20, 2020, 3 replies, in forum: Epidemics (including Covid-19)
  5. Jaybee00
    Thread

    Kynurenine pathway is altered in patients with SLE and associated with severe fatigue, 2018, Akesson et al.

    https://lupus.bmj.com/content/5/1/e000254 Conclusions Metabolites in the kynurenine pathway are altered in patients with SLE compared with...
    Thread by: Jaybee00, Oct 16, 2020, 9 replies, in forum: Health News and Research unrelated to ME/CFS
  6. Jaybee00
    Thread

    Potential Role of Neuroactive Tryptophan Metabolites in Central Fatigue: Establishment of the Fatigue Circuit, 2020, Yamashita

    https://journals.sagepub.com/doi/full/10.1177/1178646920936279 Central fatigue leads to reduced ability to perform mental tasks, disrupted social...
    Thread by: Jaybee00, Oct 16, 2020, 2 replies, in forum: Health News and Research unrelated to ME/CFS
  7. Andy
    Thread

    Hepatocyte-intrinsic type I interferon signaling reprograms metabolism [..] compensatory mechanism of the tryptophan-kynurenine pathway, 2020, Lercher

    Full title: Hepatocyte-intrinsic type I interferon signaling reprograms metabolism and reveals a novel compensatory mechanism of the...
    Thread by: Andy, Oct 14, 2020, 0 replies, in forum: Health News and Research unrelated to ME/CFS
  8. Andy
    Thread

    COVID-19 infection alters kynurenine and fatty acid metabolism, correlating with IL-6 levels and renal status, 2020, Thomas et al

    Reprogramming of host metabolism supports viral pathogenesis by fueling viral proliferation, by providing, for example, free amino acids and fatty...
    Thread by: Andy, Jun 20, 2020, 4 replies, in forum: Epidemics (including Covid-19)
  9. Andy
    Thread

    Increased Expression of (IDO) in Vogt-Koyanagi-Harada (VKH) Disease May Lead to a Shift of T Cell Responses Toward a Treg Population, 2020,Zhang et al

    Full title: Increased Expression of Indoleamine 2,3-Dioxygenase (IDO) in Vogt-Koyanagi-Harada (VKH) Disease May Lead to a Shift of T Cell...
    Thread by: Andy, May 22, 2020, 0 replies, in forum: Health News and Research unrelated to ME/CFS
  10. cassava7
    Thread

    OMF to launch clinical trials on Mestinon & Kynurenine, post-COVID19 study

    From their May Momentum 2020 newsletter & https://www.omf.ngo/maymomentum/ We are announcing THREE major research projects throughout May! [...]...
    Thread by: cassava7, May 1, 2020, 35 replies, in forum: BioMedical ME/CFS News
  11. Andy
    Thread

    The Kynurenine connection: how exercise shifts muscle tryptophan metabolism & affects energy homeostasis, the immune system & the brain, 2020, Martin

    Tryptophan catabolism through the kynurenine pathway generates a variety of bioactive metabolites. Physical exercise can modulate kynurenine...
    Thread by: Andy, Mar 28, 2020, 0 replies, in forum: Health News and Research unrelated to ME/CFS
  12. Andy
    Thread

    Serum Metabolic Profiles of the Tryptophan-Kynurenine Pathway in the high risk subjects of major depressive disorder, 2020, Sakurai et al

    Previous reports have shown that during chronic inflammation, the tryptophan (TRP)-kynurenine (KYN) pathway plays a pivotal role in the onset of...
    Thread by: Andy, Feb 7, 2020, 1 replies, in forum: Health News and Research unrelated to ME/CFS
  13. John Mac
    Thread

    The IDO Metabolic Trap Hypothesis for the Etiology of ME/CFS 2019 Kashi, Davis, Phair.

    Abstract Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating noncommunicable disease brandishing an enormous worldwide...
    Thread by: John Mac, Jul 26, 2019, 45 replies, in forum: BioMedical ME/CFS Research
  14. MeSci
    Thread

    Persistent fatigue induced by interferon-alpha: A novel, inflammation-based, proxy model of Chronic Fatigue Syndrome, 2018, Pariante et al

    Not sure whether this is really relevant, but the reference to kynurenine looked interesting. NB participants include some dodgy people, e.g....
    Thread by: MeSci, Dec 4, 2018, 458 replies, in forum: BioMedical ME/CFS Research
Showing results 1 to 14 of 14