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kynurenine

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  1. SNT Gatchaman
    Thread

    Pre-print: Post-acute COVID-19 cognitive impairment and decline uniquely associate with kynurenine pathway activation, 2022, Brew et al

    Aussie breakthrough on the long Covid condition that leaves sufferers with symptoms similar to 'traumatic brain injury (Daily Mail - no really)...
    Thread by: SNT Gatchaman, Jun 18, 2022, 13 replies, in forum: Long Covid research
  2. Andy
    Thread

    The Role of Kynurenine Pathway and NAD + Metabolism in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, 2022, Dehhaghi et al

    Abstract Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a serious, complex, and highly debilitating long-term illness. People...
    Thread by: Andy, Jun 4, 2022, 6 replies, in forum: ME/CFS research
  3. SNT Gatchaman
    Thread

    Tryptophan and the innate intestinal immunity: Crosstalk between metabolites, host innate immune cells, and microbiota: 2022, Li et al

    Tryptophan and the innate intestinal immunity: Crosstalk between metabolites, host innate immune cells, and microbiota Yunke Li, Ning Liu, Yao Ge,...
    Thread by: SNT Gatchaman, May 18, 2022, 0 replies, in forum: Other health news and research
  4. Mij
    Thread

    Kynurenine Is a Cerebrospinal Fluid Biomarker for Bacterial and Viral Central Nervous System Infections, 2019, Sühs et al

    Abstract Background The tryptophan–kynurenine–nicotinamide adenine dinucleotide (oxidized; NAD+) pathway is closely associated with regulation of...
    Thread by: Mij, Sep 3, 2021, 1 replies, in forum: Other health news and research
  5. Andy
    Thread

    Inhibition of Tryptophan Catabolism Is Associated With Neuroprotection During Zika Virus Infection, 2021, Martins Marim et al

    Zika virus (ZIKV) is an arbovirus belonging to Flaviviridae family that emerged as a global health threat due to its association with microcephaly...
    Thread by: Andy, Aug 3, 2021, 0 replies, in forum: Other health news and research
  6. Andy
    Thread

    Changes in Kynurenine Pathway Metabolites After Acute Psychosocial Stress in Healthy Males: A Single-Arm Pilot Study, 2021, La Torre et al

    Abstract Chronic stress is associated with an increased conversion of tryptophan (TRP) into kynurenine (KYN). However, only a few studies...
    Thread by: Andy, Jul 30, 2021, 1 replies, in forum: Other health news and research
  7. Possibly James May
    Thread

    Phase 1 study to access safety, tolerability, pharmacokinetics, and pharmacodynamics of kynurenine in healthy volunteers, 2021, Al-Karagholi et al

    Abstract The kynurenine pathway (KP) is the main path for tryptophan metabolism, and it represents a multitude of potential sites for drug...
    Thread by: Possibly James May, Mar 23, 2021, 0 replies, in forum: Other health news and research
  8. Andy
    Thread

    Inflammation control & improvement of cognitive function in COVID-19: is there a role for kynurenine 3-monooxygenase inhibition?, Collier et al, 2021

    Full title: Inflammation control and improvement of cognitive function in COVID-19 infections: is there a role for kynurenine 3-monooxygenase...
    Thread by: Andy, Feb 21, 2021, 0 replies, in forum: Epidemics (including Covid-19, not Long Covid)
  9. Andy
    Thread

    Searching for Peripheral Biomarkers in Neurodegenerative Diseases: The Tryptophan-Kynurenine Metabolic Pathway, 2020, Torok et al

    Neurodegenerative diseases are multifactorial, initiated by a series of the causative complex which develops into a certain clinical picture. The...
    Thread by: Andy, Dec 12, 2020, 1 replies, in forum: Other health news and research
  10. Sid
    Thread

    Molecular Psychiatry (2020): The kynurenine pathway in major depressive disorder, bipolar disorder, and schizophrenia: a meta-analysis of 101 studies

    Abstract The importance of tryptophan as a precursor for neuroactive compounds has long been acknowledged. The metabolism of tryptophan along the...
    Thread by: Sid, Nov 28, 2020, 2 replies, in forum: Other health news and research
  11. Theo
    Thread

    Evidence of Structural Protein Damage and Membrane Lipid Remodeling in Red Blood Cells from COVID-19 Patients, 2020, Thomas et al

    Both red blood cells damage and kynurine identified in LongCovid research...
    Thread by: Theo, Nov 20, 2020, 3 replies, in forum: Epidemics (including Covid-19, not Long Covid)
  12. Jaybee00
    Thread

    Kynurenine pathway is altered in patients with SLE and associated with severe fatigue, 2018, Akesson et al.

    https://lupus.bmj.com/content/5/1/e000254 Conclusions Metabolites in the kynurenine pathway are altered in patients with SLE compared with...
    Thread by: Jaybee00, Oct 16, 2020, 9 replies, in forum: Other health news and research
  13. Jaybee00
    Thread

    Potential Role of Neuroactive Tryptophan Metabolites in Central Fatigue: Establishment of the Fatigue Circuit, 2020, Yamashita

    https://journals.sagepub.com/doi/full/10.1177/1178646920936279 Central fatigue leads to reduced ability to perform mental tasks, disrupted social...
    Thread by: Jaybee00, Oct 16, 2020, 2 replies, in forum: Other health news and research
  14. Andy
    Thread

    Hepatocyte-intrinsic type I interferon signaling reprograms metabolism [..] compensatory mechanism of the tryptophan-kynurenine pathway, 2020, Lercher

    Full title: Hepatocyte-intrinsic type I interferon signaling reprograms metabolism and reveals a novel compensatory mechanism of the...
    Thread by: Andy, Oct 14, 2020, 0 replies, in forum: Other health news and research
  15. Sly Saint
    Thread

    Kynurenine Trial in ME/CFS - Bergquist

    STUDY AIM The purpose of the study is to evaluate whether kynurenine is directly connected to ME/CFS patient symptom severity. LEAD INVESTIGATORS...
    Thread by: Sly Saint, Aug 6, 2020, 5 replies, in forum: ME/CFS research news
  16. Andy
    Thread

    COVID-19 infection alters kynurenine and fatty acid metabolism, correlating with IL-6 levels and renal status, 2020, Thomas et al

    Reprogramming of host metabolism supports viral pathogenesis by fueling viral proliferation, by providing, for example, free amino acids and fatty...
    Thread by: Andy, Jun 20, 2020, 8 replies, in forum: Epidemics (including Covid-19, not Long Covid)
  17. Andy
    Thread

    Increased Expression of (IDO) in Vogt-Koyanagi-Harada (VKH) Disease May Lead to a Shift of T Cell Responses Toward a Treg Population, 2020,Zhang et al

    Full title: Increased Expression of Indoleamine 2,3-Dioxygenase (IDO) in Vogt-Koyanagi-Harada (VKH) Disease May Lead to a Shift of T Cell...
    Thread by: Andy, May 22, 2020, 0 replies, in forum: Other health news and research
  18. cassava7
    Thread

    OMF to launch clinical trials on Mestinon & Kynurenine, post-COVID19 study

    From their May Momentum 2020 newsletter & https://www.omf.ngo/maymomentum/ We are announcing THREE major research projects throughout May! [...]...
    Thread by: cassava7, May 1, 2020, 35 replies, in forum: ME/CFS research news
  19. Andy
    Thread

    The Kynurenine connection: how exercise shifts muscle tryptophan metabolism & affects energy homeostasis, the immune system & the brain, 2020, Martin

    Tryptophan catabolism through the kynurenine pathway generates a variety of bioactive metabolites. Physical exercise can modulate kynurenine...
    Thread by: Andy, Mar 28, 2020, 0 replies, in forum: Other health news and research
  20. Andy
    Thread

    Serum Metabolic Profiles of the Tryptophan-Kynurenine Pathway in the high risk subjects of major depressive disorder, 2020, Sakurai et al

    Previous reports have shown that during chronic inflammation, the tryptophan (TRP)-kynurenine (KYN) pathway plays a pivotal role in the onset of...
    Thread by: Andy, Feb 7, 2020, 1 replies, in forum: Other health news and research
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