Temporal dynamics of the plasma proteomic landscape reveals maladaptation in ME/CFS following exertion, 2025, Germain et al.

[Mij]

"Exercise is Not Producing Muscle Damage in ME/CFS: PEM May be All About Muscle Repair"

Delayed PEM affects all muscles whether I'm using them or not during exercise. If I go over my energy boundary and experience delayed PEM from walking, my whole body feels a loss of power/ weak, including my arms.

 

[Mij]

I'm having difficulty understanding what they mean by "repair" in the linked article that was posted.

 

[Jonathan Edwards]

Presumably repair is only relevant if there is damage. Muscle is damaged during normal daily activity so I agree it is a bit hard to now what is being meant here.

 

[forestglip]

I see a pathway called "SNARE interactions in vesicular transport" in the figure, but not anywhere in Supplemental Table 3.

Some of the log10q values seem different, for example the spreadsheet says "T cell receptor signaling pathway" at D1PRE [edit: D2PRE] has padj=0.00446, which comes out to -log10q=2.35, but in the figure it looks to be closer to 1.85.

I contacted the authors who confirmed the figure was not correct, and I see that they've updated the figure: