“Biomarkers of mitochondrial dysfunction and signaling in ME/CFS”
A project summary as written by Profs. Blomberg and Rosen:
Our working hypothesis of ME/CFS pathogenesis is that a person predisposed for ME is provoked to react with the major energy metabolic organelle, the mitochondria. We want to explore why after an infection, a major energy metabolic change takes place, creating a severe restriction in daily life and causing a profound lack of energy, affecting both muscular and mental (cognitive) functions. We will investigate the presence of antibodies in ME to mitochondrial proteins, especially the pyruvate dehydrogenase complex. We will also utilize our recently published reports of an innate immune mechanism which releases mtDNA into extracellular space when stimulated by certain DNA structures, and a hypothetical explanation for pathogenesis of ME.
