Resting-state functional connectivity, cognition, and fatigue in response to cognitive exertion: a novel study in adolescents with CFS (2019) Josev

I’m profiling Dr Josev in Meet The Scientists soon and wrote a summary of this study:
https://meaustralia.net/2019/06/24/teenagers-with-me-and-cfs-use-same-energy-to-think/

Reading the ME Research UK summary was interesting (and interesting that Australia’s scientists seek fund from so far away as the situation here is dire).

 

The adolescents with Paediatric ME and CFS had slower reaction times before cognitive exertion and even slower after exertion.

That could be key. Also in adults.

In my case I noticed the more severe I became the slower it was.

It graduly improved with taking the immunemodulator.

A while ago I noticed not only I can respond more quickly but even my memory is much better. I responded very fast when somebody mentioned something from a long time ago. The memory came back in a split second.

 

From the MERUK write up it reads as though testing followed a 90mins exertion period - if delayed impact/ delayed energy availability (like PEM) is part of the illness profile would it not have been illuminating to have looked at a number of time points. 90 mins exertion may impact more significantly after a few hours/ next day/ 48 hours later.
That may have been more interesting?

 

Hi @lansbergen, can I ask which immune modulator you have been taking?

 

Levamisole

 

Thanks

 

I think that makes it worse. To much strain.

I just let nature take its course and my insommia disappeared with overall improvement.

 

Sleep hygiene was a disaster - it panned out as less overall sleep and worry. Medical staff cannot understand that it will not work for everyone. Most recent appointment saw this rearing its head again with a patient blaming tone that sleep had never been addressed ( loud sigh)

 

That's an immunomodulator? I know nothing about it, Google sez (via WebMB, Mayo, etc) that it's, ahh, serious stuff, but says nothing about it being used to regulate one's immune system. ???

 

https://www.s4me.info/threads/why-d...hrondia-a7nachr-tryptophan.11324/#post-202639