Why does levamisole help me? Mitochrondia, a7nAchR, Tryptophan

levamisole is an allosteric modulator of a7nAchR

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4153835/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5398327/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5398327/

https://www.frontiersin.org/articles/10.3389/fphys.2018.00199/full

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http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.272.4223

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4153835/

https://www.researchgate.net/public...rome_c_Release_Study_on_Isolated_Mitochondria

https://pdfs.semanticscholar.org/490f/ec1709c39d335f18226144c80b33a9384bfb.pdf

 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5687317/

http://www.uss.cl/newsletter-uss/wp-content/uploads/sites/19/2016/05/Positive-modulators-of-the-α7-nicotinic-receptor-against-neuroinflammation-and-cognitive-impairment-in-Alzheimers-disease.pdf

http://www.paper.edu.cn/scholar/showpdf/MUT2AN1INTz0Mxxh

https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1471-4159.2012.07876.x

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https://pdfs.semanticscholar.org/914b/2c4064e17d4ab5e7d95a6c02308c1b9bb719.pdf

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5687317/

 

https://www.academia.edu/35915156/T...n_Receptor_and_Direct_Mitochondria_Regulation

 

Role of α7 nicotinic receptor in the immune system and intracellular signaling pathways

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4655390/

 

Modulatory effects of α7 nAChRs on the immune system and its relevance for CNS disorders

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4894934/

 

Thanks for posting.

 

I had short term remissions from severe pots (pots was gone) for 12 hours after Vermox intake, it is an anti parasite, I can say with a very high certainty that it was no placebo.

 

how severe are you? for how long do you take it? what was your onset like?

ty!

 

I was dying . Now I am mild to moderate.

I have been taking it for almost 25 years now. Lasting improvement was and still is slow.

Onset started with what seemed the worst flu ever. Never fully recovered and became slowly worse.

 

ty!

what dosages are you taking and do you see any issues with that? liver problems or kidney? neuropathies?

 

also interesting:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077236/#!po=0.714286

 

Levamisole is metabolized to aminorex.

That is why it is forbidden in horseracing.

 

The plasma elimination half-life of levamisole is fairly quick at 3–4 hours.

The metabolite half-life is 16 hours.

 

so it is either „pushing“ you like an amphetamine or it has some inhibiting mechanism on a virus or it does... ?

 

It does not push me. It relaxes. It stopped the racing brain.

When I started to take it the big suprise was that it eased the pain enough to let me sleep for a few hours.

A very long time ago it was claimed it can bring the immunesystem back to normal.

Low and high dosis have opposite effects.

The a7nAchR are on many different cells. For instance muscles and immune cells.

Symptoms depend on which cells are affected. Improvement will depend on which affected cells it acts most.

In my case there is a distinc pattern.

 

Have you tried to communicate your findings to OMF? I did so for Vermox, they said they would look into it, your experience would strengthen the need for looking into it.

 

still on it my man?

 

Yes.

 

would you tell me the dose you are taking?

thank you!

 

1ml of the 8% solution in some water every evening before going to bed.