News from PolyBio Research Foundation

I saw that the next PolyBio Symposium was mentioned in the News in Brief, so adding here as well:

PolyBio Spring Symposium
Zoom seminar with 10 minute research updates from 33 researchers.
Friday, May 16, 1100 ET / 1500 UTC
Details | Registration

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I was most interested in hearing updates regarding Morgane Bomsel's last talk about SARS-CoV-2 in the megakaryocytes/platelets, but she isn't listed as a speaker.
 


Dr. Amy Proal last week: “When people get an infection, there’s a huge assumption that it just clears after their symptoms go away… Little amounts of the pathogen [can persist] in parts of your tissue, parts of your nerves—where they can still drive inflammation and directly hijack the functioning of your mitochondria.”

Posting not an endorsement.
 
New video Road to the Cure for Long COVID

Steve Pagliuca and the PolyBio Research Foundation team detail a new program to identify Long COVID diagnostic tests and treatments.
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Steve Pagliuca is former Co-Chairman of Bain Capital.

"It's personal to me because one of my sons contracted this disease about a year ago. Since then we've experienced first hand how debilitating and disheartening this condition can be. […] We're now proud to announce we're now partnering with PolyBio to launch the Long Covid Cure Initiative. […] We're raising 8 million dollars to launch VIPER. It'll be the flagship program of the Long Covid Cure Initiative. My family has already committed 1 million dollars to help make this a reality and we hope you'll join us in this effort."​
 
"Looking back at some of PolyBio’s most influential moments of 2025–we can’t forget about this collaborative effort between Dr. Iwasaki’s Yale team & Dr. Bragée’s ME/CFS clinic in Sweden.

The PolyBio-supported study used cerebrospinal fluid to identify 2 distinct ME/CFS subtypes".

 


"I saw an article earlier pushing for more probiotic clinical trials and I thought it was the most insulting thing I’d read all day. Then this happened."

"PolyBio raked in FORTY MILLION DOLLARS promising to **URGENTLY** research LONG COVID VIRAL PESISTENCE (then needed $5M more for VIPER?) but all we see is endless fundraising for other illnesses + empire building w/data mining apps and franchisable clinics set to peddle wares they all likely have financial stakes in, too.

A lumbro trial, omg. Honestly, it feels fkn criminal at this point."

"Oh I know. $35M in 2022 and 2023 alone, yet they’ve got patients holding up fundraising certificates like crowns from Burger King, clapping like seals, while people go broke, suffer and die. https://projects.propublica.org/nonprofits/organizations/845157239"

The only good thing to come out of this is that their donations went down to $4M in 2024. They really are running a sophisticated grift at PolyBio.
 
OrganicChilli said:


"I saw an article earlier pushing for more probiotic clinical trials and I thought it was the most insulting thing I’d read all day. Then this happened."

"PolyBio raked in FORTY MILLION DOLLARS promising to **URGENTLY** research LONG COVID VIRAL PESISTENCE (then needed $5M more for VIPER?) but all we see is endless fundraising for other illnesses + empire building w/data mining apps and franchisable clinics set to peddle wares they all likely have financial stakes in, too.

A lumbro trial, omg. Honestly, it feels fkn criminal at this point."

"Oh I know. $35M in 2022 and 2023 alone, yet they’ve got patients holding up fundraising certificates like crowns from Burger King, clapping like seals, while people go broke, suffer and die. https://projects.propublica.org/nonprofits/organizations/845157239"

The only good thing to come out of this is that their donations went down to $4M in 2024. They really are running a sophisticated grift at PolyBio.
Click to expand...

What substance would you prefer they trial for an equivalent amount of money?
 
OrganicChilli said:
I would prefer they ceased all operations and handed over their money to serious scientists who are legitimately interested in solving this problem instead of boosting their careers and egos.
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Where are these serious scientists legitimately interested in solving this problem?

confused_travolta_original_acmi.original.jpg
 
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ryanc97 said:
The point is that lumbro is cheap and easy to get and thousands have tried it over the last few years and if it worked we would know.
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They're trialing Boluoke lumbrokinase which is cheap in the grand scheme of things but actually as a supplement for people who can't work it's not cheap at all. A bottle of 60 pills costs ~£100 in the UK and that'd be enough for 30 days (the trial protocol is 1 pill twice a day).

I agree with you on effectiveness.

EDIT: I've read that lumbrokinase can vary significantly from brand to brand. I haven't explored it but I thought I ought to mention the brand name and price for the one trialled.
 
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Wonder how long it will take these LC Twitter geniuses to figure out that viral persistence is also bullshit.

It's crazy what having a masters / PhD in science does to a person's confidence. Like being a gifted kid™ on steroids.

If only they weren't so blinded in their hatred of ME, they would have learned what we did painfully through decades, and could have moved on years ago. Alas.

The most disappointing thing however is that multiple MECfs orgs have been involved with what I feel I can now safely call fraud.
 
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ryanc97 said:
I dot know but they started realizing or at least they started having the view that pretty much all of the long covid researchers were not interesting in trying the drugs they wanted to trial, mainly the hardcore antiviral mabs.
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Make sense they've turned on Proal then. They think LC is tantamount to HIV which explains why they liked Proal initially given her focus on viral persistence.
 
I find it very funny that the LC VP people , when presenting with evidence that antivirals don’t work, just say you need stronger antivirals.

There is a commenter on X saying the trial was invalid because VP takes months to clear, not 21 days. How would one know that?

What is the limit of how strong antivirals can go?

I really want to see a trial with the strongest covid antivirals known to man combined over a long period of time. And then the reaction to that from the VP community.
 
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ryanc97 said:
I find it very funny that the LC VP people , when presenting with evidence that antivirals don’t work, just say you need stronger antivirals.

There is a commenter on X saying the trial was invalid because VP takes months to clear, not 21 days. How would one know that?
Click to expand...
Makes sense that Long Covid, the most unique illness in the history of mankind would take longer to ´´clear`` or to show any effect at all compared to other viruses.

On a serious note, sadly MECFS clinic who give anti-virals also pursue the same train of thought, where it for some convenient reason might take months before improvement occurs. Which allows for random fluctuations, regression or random improvement to be seen as anti virals improving the patient.
 
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