Nature: ‘It’s all gone’: CAR-T therapy forces autoimmune diseases into remission

seems CD19 wont be enough for MS, ... at least based on OCB just dropping in 1 patient and persisting in other, that's discouraging. It might still work very very well better than whatever they have now (like CD20 monoclonals or HSCT), but I read and think these 2 case reports indicate you need to reset plasma cells as well to fully cure MS.

and it's a bit weird report, unclear if they had RRMS or PPMS...

 

Probably right but I would be careful about using oligoclonal bands as an endpoint in the shorter term (less than a year). The kinetics of response is likely to be very complex and in most patients the clinical aim is to prevent new demyelinating foci. Nobody knows what determine those but it may not relate to persistent antibody production the CNS compartment directly.

It will be very interesting to see. I agree that more clinical detail would have been helpful.

 

The enchanting canvas of CAR technology: Unveiling its wonders in non-neoplastic diseases

Summary
Chimeric antigen receptor (CAR) T cells have made a groundbreaking advancement in personalized immunotherapy and achieved widespread success in hematological malignancies. As CAR technology continues to evolve, numerous studies have unveiled its potential far beyond the realm of oncology. This review focuses on the current applications of CAR-based cellular platforms in non-neoplastic indications, such as autoimmune, infectious, fibrotic, and cellular senescence-associated diseases. Furthermore, we delve into the utilization of CARs in non-T cell populations such as natural killer (NK) cells and macrophages, highlighting their therapeutic potential in non-neoplastic conditions and offering the potential for targeted, personalized therapies to improve patient outcomes and enhanced quality of life.

https://www.cell.com/med/fulltext/S2666-6340(24)00128-4

 

A review from authors in Wuhan!!
And published in something called 'Med'
Is this AI??

 

It’s an enchanting canvas!!!

 

Generally speaking you want a canvas to be evenly primed, either with rabbit size or some modern emulsion foundation, and to have some texture but no other features - certain not irregularities.

Maybe the AI picked the wrong metaphor?

 

https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2023.1298815/full

Concurrent remission of lymphoma and Sjögren’s disease following anti-CD19 chimeric antigen receptor-T cell therapy for diffuse large B-cell lymphoma: a case report