I've been thinking about this a lot lately. I think that one of the problems is that none of the charities have a track record of large projects. IiMER managed to raise a lot of money (albeit slowly, in comparison to other disease fields) for a rituximab trial but the trial (rightly) isn't going ahead. I think another large project to donate to specifically is needed to enthuse donors but none is on offer in the UK. It seems a bit of a chicken-and-egg scenario; people won't donate until they see a big project, and a big project is perhaps unlikely to be mooted without a lot of money already sloshing about. Meanwhile, we have a lot of small charities rather than one big one and that means that research donations get split amongst them rather than pooled, which limits what they can do. I wish they would amalgamate, but that seems unlikely, given their internal politics.