Low-dose Naltrexone articles and experiences

[Utsikt]

I don’t know where else to ask: does anyone have a list of the ongoing trials of LDN for ME/CFS or LC?

 

[MinIreland]

I am not sure if this has been posted in this thread before, but I recently discovered this group:

LDN Research Trust

The LDN Research Trust Charity works to raise funds for research trials. We have helped over 100,000 people obtain LDN from a General Practitioner or Consultant, either through the National Health Service or by private prescription. We are proud to have

ldnresearchtrust.org

@Utsikt, there is also a specific page where they collect all the trials. I'm sure you could contact them if you're looking for current trials: https://ldnresearchtrust.org/ldn-clinical-trials

PS. This is not specific for ME/CFS, it's focused on LDN for various diseases and chronic illnesses.

 

[forestglip]

See thread: Low-Dose Naltrexone: What is the Evidence? A Narrative Review, 2026, Gouda

A total of 105 studies were reviewed, including 15 randomised controlled trials (RCTs) in chronic pain, autoimmune and neuroimmune disorders, gastrointestinal disease, dermatological conditions, post-infectious syndromes, mental health and oncology.

Across these fields, early positive findings from uncontrolled studies were rarely replicated in placebo-controlled trials. Most available evidence consists of case reports and small feasibility studies that are prone to publication bias and rely heavily on subjective outcomes.

LDN is generally safe, inexpensive and well tolerated, with most studies using a daily dose of 4.5 mg.

Although these features contribute to its appeal, current evidence does not support routine clinical use.

 

[forestglip]

Some posts discussing preliminary results of Luis Nacul's trial of LDN have been moved to:

Trial registration: Low-dose Naltrexone for Post-COVID Fatigue Syndrome, 2022, Luis Nacul, British Columbia Women's Hospital & Health Centre