Threads about articles and people's experiences with LDN have been merged into this single thread. Medscape: Low-dose Naltrexone Explored as Option for Chronic Pain (by Miriam Tucker) Miriam Tucker's third article from the recent 2- day summit at the Bateman-Horne Center Low-dose Naltrexone Explored as Option for Chronic Pain Naltrexone is an opiate antagonist currently available in a daily 50-mg tablet dose for the treatment of alcohol and opioid dependence. But in addition to opioid receptor antagonism, the drug also appears to exert anti-inflammatory effects via a separate mechanism targeting microglial cells. ... There is currently no drug approved by the US Food and Drug Administration for ME/CFS, and treatment of the condition focuses on relief of symptoms including widespread pain. Many patients with ME/CFS also meet clinical criteria for fibromyalgia, for which LDN has shown benefit in several of Younger's studies.