1. Sign our petition calling on Cochrane to withdraw their review of Exercise Therapy for CFS here.
    Dismiss Notice
  2. Guest, the 'News in Brief' for the week beginning 18th March 2024 is here.
    Dismiss Notice
  3. Welcome! To read the Core Purpose and Values of our forum, click here.
    Dismiss Notice

Frontiers review - Chronotropic incompetence an overlooked determinant of symptoms and activity limitation in ME/CFS (prov. 2019) Davenport et al

Discussion in 'ME/CFS research' started by Ravn, Mar 8, 2019.

  1. alex3619

    alex3619 Senior Member (Voting Rights)

    Messages:
    2,129
    I have only read the link above, not the paper. This is about the heart's response, not the heart rate. In other words, its about increase in heart rate, not absolute heart rate. I am not sure this explanation is correct, but its the only one that makes sense to me just now. As oxygen use goes up, our heart rate does not go up to match.
     
    ukxmrv, Inara, Sly Saint and 5 others like this.
  2. Sunshine3

    Sunshine3 Senior Member (Voting Rights)

    Messages:
    622
    Makes so much sense to me, I always feel that my heart can't sustain any simple activity..like I'm in some kind of heart failure. I'm delighted to this study published. Also, HR has nothing to do with pem for me. I can get severe pem from having a visitor.
     
    ukxmrv, Trish and Sean like this.
  3. roller*

    roller* Senior Member (Voting Rights)

    Messages:
    249
    chronotropic incompetence = inability to raise heart rate

    Heart rate:
    40 - 60 (+50 %) = mecfs
    60 - 140 (+230 %) = controls

    VO2 oxygen uptake:
    200 - 1400 (+ 7x) = mecfs
    300 - 1900 (+ 6x) = controls

    why didnt they force the mecfs to go to the "predicted heart rate max" ?
    what would happen ?


    [​IMG]
     
    andypants likes this.
  4. roller*

    roller* Senior Member (Voting Rights)

    Messages:
    249
    would have thought, that encountering a thing that causes damage to me, would increase heart rate ?
    we came in near-coma and left in near-coma... so much for the stepper

    now, the "emotional pem".
    does watching a horror movie increase your heart rate, after all ?

    is it possible to rent such a heart monitor, perhaps in the pharmacy ?
     
  5. Wonko

    Wonko Senior Member (Voting Rights)

    Messages:
    6,674
    Location:
    UK
    This makes no sense to me.

    I have only experienced a fixed HR during one period, when I was on a beta blocker, atenolol. Then I was restricted because my HR wouldn't go above 60bpm. Given I have traditionally used 'adrenaline' to enable me to get stuff done when I need to not being able to was crippling.

    My HR is traditionally high, tachycardic in fact, often even when at rest. Standing can increase my HR to the 120-140 bpm area. An instant of the wrong type of thought can increase it to 160bpm for tens of minutes.

    I didn't think I was alone in this amongst PwME, but this suggests I am.
     
    Inara, andypants and Trish like this.
  6. Trish

    Trish Moderator Staff Member

    Messages:
    51,871
    Location:
    UK
    I don't understand it either. My pulse goes from around 68 when resting to 110+ after 2-3 minutes moving slowly about the house (no stairs).
     
    leokitten, andypants and Wonko like this.
  7. Wonko

    Wonko Senior Member (Voting Rights)

    Messages:
    6,674
    Location:
    UK
    If I work really hard at resting then I can get my HR down to high 60s, occasionally, more often low to mid 70s, but I have to be well rested for that, and anything more than a few minutes upright will send it at least into the high 90s. Once it's been like that for a few minutes it rises to low 100s even if I'm not doing anything. If I then do stuff it's 115-130. This is an improvement on how it used to be.

    And so it goes.

    How long this takes may, but only may, depend on how 'rested' I am, but once my HR is high even lying down immobile doesn't cause it to drop much, for quite a while - in fact it's often higher when lying down after 'exertion' (e.g. standing up long enough to make a cuppa - that sort of 'exertion').

    I'm still trying to get a handle on what's going on, but it seems to depend, at least partially, on something I am not monitoring.

    I've tried seeing what effects eating, different types of food, not eating, altering the timing and duration of sleep, adding in a few seconds of 'high intensity' exercise (a few reps of a minimum weight deadlift every couple of days), varying durations of 'low intensity' exercise (lurching).

    The results make no sense e.g. 3 reps of deadlifts actually seem to reset my HR down to high 70s - low 80's, no matter what it was before, but walking, that raises it, and it stays elevated for anything from 5 hours to days, even whilst sleeping.

    It's nonsense.

    So the above paper, runs counter to my experience. If it is valid for all PwME then I ain't one, no matter what my symptoms suggest..
     
    leokitten and andypants like this.
  8. Trish

    Trish Moderator Staff Member

    Messages:
    51,871
    Location:
    UK
    I think they did say it's a subgroup who don't have POTS, which may explain it.
     
    Chezboo, Sean, andypants and 2 others like this.
  9. Mithriel

    Mithriel Senior Member (Voting Rights)

    Messages:
    2,815
    My heart rate goes up when I do anything and can go very high if I am forced to stay upright (doctor's office was worst) but from tracking my HR I have found that when I am particularly bad my heart rate drops. At the same time I can feel dizzy and ill if I try to do something.

    I have seen this phenomenon happen to other people in HR monitoring groups so I am not alone.
     
    andypants and Wonko like this.
  10. Jonathan Edwards

    Jonathan Edwards Senior Member (Voting Rights)

    Messages:
    13,273
    Location:
    London, UK
    I don't understand the figure. Presumably there are lots of dots, some on top of each other, because there are lots of subjects or test runs. But shouldn't a test run be given by a line - staring at low oxygen uptake and moving to high? And why does the control line start higher for oxygen uptake?

    If the x axis is change in heart rate rather than actual heart rate why isn't there much more scatter?

    I am obviously not understanding what is being shown.
     
    andypants, Trish and Wonko like this.
  11. Snow Leopard

    Snow Leopard Senior Member (Voting Rights)

    Messages:
    3,819
    Location:
    Australia
    If they truly have chonotropic incompetence, there is no "forcing", the patients will simply need to stop early.

    What is interesting is that in young healthy people, deconditioning can actually result in slightly higher than normal heart rates at VO2Max than trained participants.

    The idea is to see if there is something interfering with normal heart rate response to exercise, at least in the subgroup of patients considered to have chronotropic incompetence. Increased latency would suggest the normal mechanisms are not functioning correctly. Likewise, if muscle drive increases but heart rate does not increase appropriately, it suggests there is a problem. This is also assuming "normal" levels of ventilation (no hypoventilation).

    An example of a surface EMG study (vastus lateralis in this case):
    https://www.ncbi.nlm.nih.gov/pubmed/27697301
    An appropriate study of EMG and their interpretation is admittedly a little more complicated than many people in the field suggest if you want to consider the number of muscle fibres activated and want to use this to imply something about the twitch characteristics of those fibres.
    https://www.physiology.org/doi/full/10.1152/japplphysiol.00280.2015
    Also, for the technically inclined:
    https://www.physiology.org/doi/full/10.1152/japplphysiol.00162.2014

    Some reading (healthy participants):
    "Kinetics of heart rate responses to exercise"
    https://www.tandfonline.com/doi/abs/10.1080/02640418808729792
    "Early ventilation-heart rate breakpoint during incremental cycling exercise."
    https://www.ncbi.nlm.nih.gov/pubmed/23945972
    In the above study, note the difference in HR slope before and after the VT, also note that heart rate response to an increased rate of breathing (with a small amount of latency).

    As others have pointed out, some people have tachycardia, rather than chronotropic incompetence although perhaps there could be an overall flattening of the heart rate curve.

    One hypothesis is that the low performance of patients is due to low cardiac output, but this can only explain things for a minority of patients. It is true that patients with congenital heart disorders tend to have exercise intolerance that can be explained due to limited cardiac output (one person I know was cured after they finally convinced a surgeon to operate).

    I will say that in the recently published 2 day CPET study by Nelson et al, they tested various hypotheses relating to heart rate increases and also HR during the recovery phase and found no differences between patients and controls (not yet published data).

    My hypothesis which is different from that of chronotropic incompetence or dysautonomic failure, rather the muscle fibres are not able to put out the same level of force for a given level of stimulation on the second day of the CPET, at around the ventilatory threshold, leading to more muscle fibres being recruited, and a greatly increased sense of effort as a result, leading to patients stopping the test earlier.

    The reason for this is uncertain. We do know that the issue is unlikely to be due to the mitochondria themselves.

    Natelson, Vermeulen and Wong propose some issue with oxygen transport to the muscle.
    http://www.clinsci.org/content/97/5/603
    https://translational-medicine.biomedcentral.com/articles/10.1186/1479-5876-8-93
    https://www.ncbi.nlm.nih.gov/pubmed/1446478

    Various researchers including certain Australians have proposed issues with pH buffering, which could also be due to K+, rather than merely lactate. Along with other metabolic abnormalities, but it is uncertain how these fit into a coherent theory.

    Phair proposes reduced central drive due to the IDO/Tryptophan metabolic trap. I disagree with this as it is inconsistent with what we know about exercise physiology and the findings so far, but we'd need EMG measurements to completely dismiss that hypothesis.

    An aside, in neuromuscular diseases, there is a disporportionate increase in VO2 without workrate increases: https://www.ncbi.nlm.nih.gov/pubmed/6684223
     
    Last edited: Mar 25, 2019
  12. alex3619

    alex3619 Senior Member (Voting Rights)

    Messages:
    2,129
    My guess is its impossible. How do you force the impossible?
     
    roller*, Sean, Wonko and 1 other person like this.
  13. Sean

    Sean Moderator Staff Member

    Messages:
    7,044
    Location:
    Australia
    Yeah, that was my first question about it. Those two plot lines are just a bit too neat and clean.
     
    andypants likes this.
  14. Pyrrhus

    Pyrrhus Established Member (Voting Rights)

    Messages:
    37
    Location:
    U.S., Earth
    Thank you so much, @Snow Leopard , for the intriguing crash course in exercise physiology. I still have a lot to learn about this subject.

    Your hypothesis makes perfect sense. And I see why an EMG would be able to confirm or refute your hypothesis. But I wouldn’t say that your hypothesis is necessarily inconsistent with chronotropic incompetence, dysautonomic failure, or mitochondrial problems.

    For contrast, I’ll share my current understanding/hypothesis:

    1) Impaired functioning of hypothalamus and brainstem lead to the following two dysautonomic failures:
    —a) Failure to dilate the arterioles supplying the exercising muscles with oxygen, which leads to:
    ——i) A lower anaerobic threshold
    ——ii) Overstressed mitochondria ejecting large amounts of H+ ions into the extracellular space
    ——iii) Increase in micro-tears in muscle fibers, caused by the increased oxidative stress
    —b) Failure to increase the heart rate (HR) appropriately in response to exertion, resulting in:
    ——i) Chronotropic incompetence OR
    ——ii) POTS
    2) In the 1-3 days after exercise, there is temporary mitochondrial dysfunction as the mitochondria heal, leading to:
    —a) Reduction in force generated by muscle contraction, leading to:
    ——i) Recruitment of additional muscle fibers on day 2 of CPET
    ——ii) Increased perception of effort

    Please let me know which of the above are inconsistent with what is known about exercise physiology, or inconsistent with the literature!

    Thanks again.

    Edited: removed reference to P2X receptors and delayed onset muscle soreness
     
    Last edited: Mar 26, 2019
    Sean and Inara like this.
  15. Snow Leopard

    Snow Leopard Senior Member (Voting Rights)

    Messages:
    3,819
    Location:
    Australia
    Is this the problem though?

    Dilation of arteries leads to reduced blood pressure and heart rate due to increased blood flow.

    Note that the post exercise hypotension noted in healthy people is likely associated with prolonged dilation of arteries (1-2 days) and proportionally more blood being distributed to the periphery. It is suggested that this occurs due to the withdrawal of the sympathetic tone (which was increased during exercise), leading to lower than usual levels of catecholamines.
    During recovery, a response to this vasodilation is increased sympathetic activity and reduced vagal tone.

    Peripherally, the cells in blood vessels try to balance their response to catecholamines by altering their expression of alpha vs beta adrenergic receptors for example. But peripheral vasodilation in response to exercise is primarily driven by local chemical factors.

    https://www.ncbi.nlm.nih.gov/pubmed/8282635
    https://www.nature.com/articles/1001377
    https://courses.washington.edu/conj/heart/arterioles2011.htm

    It's kind of ironic that there are two opposing theories one is the "persistent arousal" hypothesis by Wyller and others which proposes increased sympathetic drive (and all the associated psychobabble of "stress" etc), whereas Phair's hypothesis involves the opposite, attenuated sympathetic drive...
     
    Last edited: Mar 26, 2019
    Inara, Pyrrhus and obeat like this.
  16. Pyrrhus

    Pyrrhus Established Member (Voting Rights)

    Messages:
    37
    Location:
    U.S., Earth
    Thank you for the clarification. It sounds like one might have to posit anti-adrenergic antibodies, not some central mechanism, if one wanted to posit failure of arteriole dilation then. (Assuming it’s consistent with observations on blood pressure during exertion.)

    I’m curious- you haven’t mentioned David Systrom’s work, what is your take on his work? As I understand it, his work concerns the failure of central veins to constrict appropriately during exercise, which could be due to dysautonomia.
     
  17. unicorn7

    unicorn7 Senior Member (Voting Rights)

    Messages:
    338
    I have always felt that it seems more like a parasympathetic problem, there is something wrong with the rest phase. Normal resting doesn't work and I have always felt that, even when mild, a PEM cascade seemed to start the moment I started to rest.
     
  18. Snow Leopard

    Snow Leopard Senior Member (Voting Rights)

    Messages:
    3,819
    Location:
    Australia
    I haven't looked into it in any depth, he believes exercise intolerance in POTS patients is due to pre-load failure.

    But I don't see why the central veins would fail to constrict with the peripheral veins also failing to dilate at the same time?
     
  19. roller*

    roller* Senior Member (Voting Rights)

    Messages:
    249
    it seems, that inclining (uphill) walking has a huge impact on heart rate (thats what i understand)

    has this been tested, ever ?
    how mecfs / controls rate in incline exercise?
     
  20. Snow Leopard

    Snow Leopard Senior Member (Voting Rights)

    Messages:
    3,819
    Location:
    Australia
    The main issue with inclines is simply that it takes substantially more power to climb than walking on a flat plane. Otherwise there is nothing particularly special.
    A graded CPET on a treadmill can simulate specific gradients by requiring a specific amount of power.
     
    Wonko, Trish and Sean like this.

Share This Page