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Circulating leptin levels in patients with [ME], [CFS] or fibromyalgia a systematic review protocol, 2020, Musker et al

Discussion in 'BioMedical ME/CFS Research' started by Andy, Nov 3, 2020.

  1. Andy

    Andy Committee Member & Outreach

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    Full title: Circulating leptin levels in patients with myalgic encephalomyelitis, chronic fatigue syndrome or fibromyalgia: a systematic review protocol
    Open access, https://journals.lww.com/jbisrir/Ab...in_levels_in_patients_with_myalgic.99794.aspx
     
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  2. Michiel Tack

    Michiel Tack Senior Member (Voting Rights)

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    It says that they used GRADEpro GT GDT for their summary of findings table. It seems that this is a common software programs that is used to quickly collect data from and rate studies in reviews. https://gradepro.org/product/#about

    Does anyone have any experience with it?

    Tutorial video:
     
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  3. DigitalDrifter

    DigitalDrifter Senior Member (Voting Rights)

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    Doesn't say what criteria, so I'm not convinced that all these patients have genuine ME. I think loose criteria leads to problems replicating results.
     
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  4. Andy

    Andy Committee Member & Outreach

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  5. Hutan

    Hutan Moderator Staff Member

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    Authors:
    Musker, Michael1,2,3;
    McArthur, Alexa2;
    Munn, Zachary2;
    Wong, Ma-Li1,3,4

    1 Mental Health and Wellbeing, South Australian Health and Medical Research Institute, Adelaide, SA, Australia
    2 The Centre for Evidence-based Practice South Australia (CEPSA): A JBI Centre of Excellence, Adelaide, SA, Australia
    3 Department of Psychiatry, Flinders University, Adelaide, SA, Australia
    4 Department of Psychiatry, Upstate University, New York, NY, USA

    Corresponding: Dr Michael Musker, michael.musker@sahmri.com

    So, a South Australian project. The institutions involved appear to have a mental health focus.
     
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  6. MEMarge

    MEMarge Senior Member (Voting Rights)

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    @Caroline Struthers may know about this.
    Though as Hutan states it it comes from a psych base.
     
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  7. Caroline Struthers

    Caroline Struthers Senior Member (Voting Rights)

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    I know a bit about GRADE and consider it pseudoscience along with the Cochrane risk of bias tool. GRADE people really seem to love it though. I guess it must produce very impressive looking tables. I remember one top level GRADE person giving a presentation once about how the GRADE predictions of whether the evidence was reliable or not turned out not to be very reliable! He was very disappointed and surprised, and determined to try and work out why GRADE was not very reliable at detecting the reliability of research. It would be better if such energy could be directed at improving the reliability of research rather than improving tools to detect unreliability. Hey ho.
     
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  8. Caroline Struthers

    Caroline Struthers Senior Member (Voting Rights)

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    I found the study Gerald Gartlehner presented. It was about stability not reliability. https://www.ncbi.nlm.nih.gov/books/NBK321518/. I was not a fan of GRADE before...and his presentation of these findings just confirmed my suspicions that it's pretty useless. But all the EBMers use it.
     
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  9. shak8

    shak8 Senior Member (Voting Rights)

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    comparing leptin levels (as leptin acts immunologically, similar to IL-6, it is theorized) could be of interest in delineating who has ME/CFS vs who has fibro.

    Though, I don't know that it is vitally important to know this.
     
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  10. Snow Leopard

    Snow Leopard Senior Member (Voting Rights)

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    I've met Dr Musker, he didn't actually have strong beliefs about etiology and is leading the team because he has experience as a clinician, skilled with enrolling patients into studies.
    The project/team was started under Julio Licinio, a Brazilian with a strong focus on biological-psychiatry, with an interest in leptin. Most of his research involves trying to find biomarkers.

    They conducted a study monitoring IL-6 and leptin levels at 7 minute intervals over 8 hours:
    http://sacfs.asn.au/news/2016/02/02_13_sahmri_calling_for_research_participants.htm

    I guess that paper should be published soon.
     
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