A Critical Review to Investigate Chronic Fatigue Syndrome as Sleep Disorder, 2019/2020, Gupta

[Dolphin]

Free fulltext:
https://ecronicon.com/ecne/a-critic...hronic-fatigue-syndrome-as-sleep-disorder.php

Research Article

Volume 12 Issue 1 - 2020

A Critical Review to Investigate Chronic Fatigue Syndrome as Sleep Disorder

Aman Gupta1*, Ramesh C Deka2 and Shruti Gupta3

1Sleep Medicine Diplomate, Nuffield Department of Clinical Neurosciences, University of Oxford, England, Visiting Fellowship fMRI. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School Boston, USA

2Professor Emeritus and Adviser to Director, Indira Gandhi Institute of Medical Sciences and the Ex-Director of All India Institute of Medical Sciences, New Delhi, India

3Managing Partner Advance Clinical and Regulatory, Delhi NCR, India

*Corresponding Author:Aman Gupta, Sleep Medicine Graduate Reading, Nuffield Department of Clinical Neurosciences, University of Oxford, England, Visiting Fellowship fMRI. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School Boston, USA.

Received: September 20, 2019; Published: December 31, 2019




Abstract

Introduction: Chronic fatigue syndrome is associated with marked fatigue and sleep disturbance specifically the non-restorative sleep. This has led to a though process among the Scientists to rule out possibility of association of CFS with Sleep Disorders. Researchers have tried to investigate the causal relationship between the two by virtue of multiple experiments, however consensus on the same still lacks.

Methods and Results: In current review, critical analysis of individual studies was conducted evaluating credibility of experiments leading to a final opinion pertaining to Chronic Fatigue Syndrome association with Sleep Pathology. Possible overlaps among different mechanisms were also identified to provide robust conclusion.

Conclusion: Current review suggests that Chronic Fatigue Syndrome and Sleep Disorders can be more of comorbid rather than having a causal relationship. Hence there is a mix type of evidence which tries to build relationship between the two but definite conclusion clearly demonstrating CFS as a sleep disorder cannot be reached.

Keywords: Chronic Fatigue Syndrome; Sleep Disorders; Pathophysiology of CFS

 

[Hutan]

Conclusion: Current review suggests that Chronic Fatigue Syndrome and Sleep Disorders can be more of comorbid rather than having a causal relationship. Hence there is a mix type of evidence which tries to build relationship between the two but definite conclusion clearly demonstrating CFS as a sleep disorder cannot be reached.

I haven't read the study, just the abstract, but a review of literature to attempt to answer the question 'is CFS a sleep disorder?' seems like a useful thing to do. The conclusion seems helpful.

Full text is free access.

 

[Hutan]

Clinically CFS can be defined as disorder in which more than 6 months of history of fatigue exists with no corresponding organic/physical or psychiatric pathology involvement.

Umm, clearly it is possible to define CFS in this way, but if you do, you are wrong.

(Incidentally, the English in this paper is poor. It's distracting; it should be better in an English language publication. It's published in E-Cronicon - the homepage says:

The society of E-Cronicon is dedicated towards the promotion of open access publication of research that reduces the frontier to assess the dossier needed.

which isn't reassuring.)

Recently other symptoms like sleep fragmentation, delay in falling asleep and excessive day time sleeping are also added to rule out the diagnosis of CFS.

Really?

Some interesting studies are discussed; but it's very patchy. I know there are more CFS sleep studies out there than are reviewed here. It doesn't get into questions of sleep architecture (deep sleep/REM sleep).

Pasting this here as yet another example of cortisol levels not being found to be abnormal.

Rahman and his team conducted a case control study in which CFS patients (n = 15) and healthy subjects (n = 15) were compared on behavioral outcomes for 5 days. ..Cortisol (salivary) levels were also recorded [10]. In CFS group, there were significant complaints of pain, disability and sleep disturbance. When compared with healthy group Cortisol levels, sleep duration and quality, actigraphy showed no difference in both groups.

This article reads like a literature review done prior to a study using fMRI.

Differential diagnosis of CFS, clarity of symptomology, interpretation and linkage of subjective versus objective measures of sleep is required to make final recommendations in this subject matter. Functional imaging and other novel techniques need to be employed to find relationship between the two.

The lead author's details are as follows:

Sleep Medicine Diplomate, Nuffield Department of Clinical Neurosciences, University of Oxford, England, Visiting Fellowship fMRI. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School Boston, USA

 

[ME/CFS Skeptic]

Some list E-Cronicon as a predatory publisher: https://beallslist.net/