something in the blood

We do a number of studies on blood samples, we capture plasma and PBMCs, sometimes we captures serum and RBCs. What type of markers do you guys think should be looked at? Or what type of assays should be performed on these biomarkers? You can even suggest combinations. Specific names should be...

Abstract Myalgic Encephalomyelitis (ME; sometimes referred to as chronic fatigue syndrome) is a relatively common and female-biased disease of unknown pathogenesis that profoundly decreases patients' health-related quality-of-life. ME diagnosis is hindered by the absence of robustly-defined and...

Good grief, a new blog. Several small and quite different ME/CFS studies have come up with the same tantalising finding – and now a team of two very talented resarchers, one a patient, are embarking on a robust replication that could help move the whole field forward. The finding? That if you...

Link to post with the abstract of the final published paper here Preprint Dysregulated Platelet Function in Patients with Post-Acute Sequelae of COVID-19 Anu Aggarwal; Tamanna K. Singh; Michael Pham; Matthew Godwin; Rui Chen; Thomas M. McIntyre; Alliefair Scalise; Mina K. Chung; Courtney...

Link to Simon M's blog about the research: Remarkable researchers hunting for ‘something in the blood’ of people with ME "In this research we are looking at microclots in the plasma of ME/CFS patients and healthy controls and we will conduct experiments to look at the effect of patient serum...

Abstract Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a disabling disorder characterized by disrupted daily patterns of activity, sleep, and physiology. Past studies in ME/CFS patients have examined circadian rhythms, suggested that desynchronization between central and...

Abstract A proportion of COVID-19 reconvalescent patients develop post-COVID-19 syndrome (PCS) including a subgroup fulfilling diagnostic criteria of Myalgic encephalomyelitis/Chronic Fatigue Syndrome (PCS/CFS). Recently, endothelial dysfunction (ED) has been demonstrated in these patients, but...

Decreased NO production in endothelial cells exposed to plasma from ME/CFS patients Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating disease characterized by severe and persistent fatigue. Along with clinical studies showing endothelial dysfunction (ED) in a...

Moved from Six-month sequelae of post-vaccination SARS-CoV-2 infection: a retrospective cohort study of 10,024 breakthrough infections, 2021, Taquet et al @Hutan thank you, I believe it's all coming together and Long Covid will have been instrumental. The Pretorius micro-clot finding is...

For the abstract of the published paper, go to post #9 Preprint Abstract Myalgic Encephalomyelitis and chronic fatigue syndrome is a multisystem illness characterized with extreme muscle fatigue associated with pain, neurocognitive impairment, and chronic inflammation. Despite intense...

BACKGROUND Fibromyalgia (FM) and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) are devastating metabolic neuroimmune diseases that are difficult to diagnose because of the presence of numerous symptoms and a lack of specific biomarkers. Despite patient heterogeneity linked to...

Any ideas?

By Open Medicine Foundation full article here: https://www.sanluisobispo.com/news/state/california/article229756099.html [have looked at the link but can't find the published paper?] eta: link now works this one takes you to where it's listed...

EDIT: SUMMARY OF LATEST VERSION OF BLOG POSTED INSTEAD Moderator's note: This post and relevant replies have been copied from this point, https://www.s4me.info/threads/nih-accelerating-research-on-me-cfs-meeting-4th-and-5th-april-2019.7745/page-14#post-161538, in the Accelerating Research on...

Another important one: https://insight.jci.org/articles/view/89376