research methodology

Full title: An exploratory study of discrepancies between objective and subjective measurement of the physical activity level in female patients with chronic fatigue syndrome Highlights • There is a discrepancy between self-report and objective activity measures in CFS. • The activity diary...

Background Despite evidence of selective outcome reporting across multiple disciplines, this has not yet been assessed in trials studying the effects of exercise in people with cancer. Therefore, the purpose of our study was to explore prospectively registered randomised controlled trials (RCTs)...

Split from The course of the illness for ME patients in Norway, 2021, Schei and Angelsen The potential effect of sample biases on DecodeME Summary: there is some evidence that this could be a problem, but is not clear how big a problem and it may be possible to adjust for possible biases...

The idea of GRADE to provide a recipe for making decisions for people who are not themselves capable of making such decisions on their own is a flawed and dangerously counterproductive idea in a medical context. The pseudo-arithmetic structure of allocating evidence to 'grades' has no purpose...

When is lack of scientific integrity a reason for retracting a paper? A case study. Abstract: This editorial has just come out in the Journal of Psychosomatic Research. It is a discussion of issues that arose from this 2004 publication: This study is a triple-blinded randomised controlled...

Full title: Cognitive behavioural therapy with exposure and response prevention in the treatment of obsessive-compulsive disorder: A systematic review and meta-analysis of randomised controlled trials Open access, https://www.sciencedirect.com/science/article/pii/S0010440X21000018 Posted for...

I know much of this is old hat, but just wanted to revisit, with a particular thought in mind. Possibly in the wrong thread, in which case mods please feel free to relocate. As best I understand this, though others here far better qualified: Surely a "controlled" trial is where you control so...

Exercise-induced hypoalgesia after acute and regular exercise: experimental and clinical manifestations and possible mechanisms in individuals with and without pain https://journals.lww.com/painrpts/Fulltext/2020/10000/Exercise_induced_hypoalgesia_after_acute_and.11.aspx mentions fibromyalgia...

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0172792 (as per abstract, not just about italian psychologists) I like the term QRP (Questionable research practices); @dave30th could make good use of it.

Open access, https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD011216.pub2/full So-called alternative medicine for post-caesarean pain? A Cochrane review https://edzardernst.com/2020/10/so-called-alternative-medicine-for-post-caesarean-pain-a-cochrane-review/

https://www.preprints.org/manuscript/202009.0744/v1

Provisionally accepted opinion article in frontiers in Pediatrics - Paediatric Neurology Review of the Quality Control Checks Performed by Current Genome-Wide and Targeted-Genome Association Studies on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome by Nuno Sepulveda, Anna D. Grabowski...

The Development of a Consistent Europe-Wide Approach to Investigating the Economic Impact of Myalgic Encephalomyelitis (ME/CFS): A Report from the European Network on ME/CFS (EUROMENE) Authors Derek F.H. Pheby 1,* , Diana Araja 2, Uldis Berkis 3, Elenka Brenna 4 , John Cullinan 5...

I have just seen this new paper on Twitter. A timely reminder that imaging and the subsequent analysis is not an exact science. https://www.biorxiv.org/content/10.1101/843193v1 Abstract Data analysis workflows in many scientific domains have become increasingly complex and flexible. To assess...

I would like to use this thread for a discussion on the effects of a lack of blinding in randomized trials, something that frequently comes up in our discussions elsewhere on the forum. Ever since the new risk of bias (RoB 2) tool for Cochrane came out I’ve been trying to learn more about...

https://www.bmj.com/content/366/bmj.l4898.full?ijkey=gzAdEdyR713TWzf&keytype=ref

Sandler, C; Llloyd, A Barry, B (2016), Fatigue Exacerbation by Interval or Continuous Exercise in Chronic Fatigue Syndrome, Medicine & Science in Sports & Exercise: October 2016 - Volume 48 - Issue 10 - p 1875–1885 doi: 10.1249/MSS.0000000000000983 /...

I’m wondering if anyone is aware of any appropriate mouse models of ME/CFS? I’m familiar with the Japanese model of putting the mice/rats in a layer of water, but that’s really a model of chronic stress, not ME/CFS. Are there any others?

Real-world studies no substitute for RCTs in establishing efficacy January 19, 2019 https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(18)32840-X/fulltext?utm_campaign=lancet&utm_content=83224321&utm_medium=social&utm_source=twitter&hss_channel=tw-27013292#.XEgvxfcH2L0.twitter...

http://journals.sagepub.com/doi/abs/10.1177/1359105318805819?journalCode=hpqa