research methodology

paper here: https://psycnet.apa.org/record/2021-45656-003 Potentially harmful therapies: A meta-scientific review of evidential value. Abstract Lilienfeld (2007, Psychological treatments that cause harm. Perspectives on Psychological Science, 2, 53) identified a list of potentially harmful...

Carley ME, Chaparro LE, Choinière M, Kehlet H, Moore RA, Van Den Kerkhof E, Gilron I., Pharmacotherapy for the Prevention of Chronic Pain after Surgery in Adults: An Updated Systematic Review and Meta-analysis. Anesthesiology. 2021 Aug 1;135(2):304-325. doi: 10.1097/ALN.0000000000003837. PMID...

There is a thread that tries to collect adequately controlled clinical trials and reviews on therapist-delivered/ non-drug interventions for illnesses and symptoms that don't have biomarkers yet here. Thought it could be also helpful to have a meta-thread collecting both well done and badly...

More than half of Dutch scientists regularly engage in questionable research practices, such as hiding flaws in their research design or selectively citing literature, according to a new study. And one in 12 admitted to committing a more serious form of research misconduct within the past 3...

Interesting article but ironic given the author's role with COPE, which whitewashed PACE, and Cochrane, given the organization's failure to deal with exactly this. Problem is that the people who make those statements only ever apply them to things they don't like, I would bet a good sum that the...

Abstract Background: Patient-reported outcome measures (PROMs) are influenced by psychosocial factors, but it is unknown whether we can influence PROM scores by modifying the mindset of the patient. Purpose: We assessed whether priming affects scores on PROMs. Methods: In all, 168 patients...

(This is a reference to the discussion on bias due to a lack of blinding here.) Bull, L. (2007). Sunflower therapy for children with specific learning difficulties (dyslexia): A randomised, controlled trial. Complementary Therapies in Clinical Practice, 13(1), 15–24...

Abstract Control conditions are the primary methodology used to reduce threats to internal validity in randomized controlled trials (RCTs). This meta-analysis examined the effects of control arm design and implementation on outcomes in RCTs examining psychological treatments for depression. A...

When we discuss the problems with trials on cognitive behavioral therapy (CBT) and graded exercise therapy (GET) we usually mention things like lack of blinding + subjective outcomes or the lack of a credible control group etc. These are methodological weaknesses that are generally regarded as...

Full reference: Boot, W. R., Simons, D. J., Stothart, C., & Stutts, C. (2013). The pervasive problem with placebos in psychology: Why active control groups are not sufficient to rule out placebo effects. Perspectives on Psychological Science, 8(4), 445-454. Link to fulltext...

This article although not about ME/CFS has been cited in a number of papers: Citations of: Evidence-Based Practice and Psychological Treatments: The Imperatives of Informed Consent https://philarchive.org/citations/BLEEPA https://www.frontiersin.org/articles/10.3389/fpsyg.2016.01170/full

As the title indicates. Looking for examples of such trials. Systematic reviews (*) of trials that excluded (or downgraded to very low quality) non-blinded trials that used only subjective outcomes as primary endpoints also welcome. Suggestions on amendments to the threads' title or topic...

A meta-analysis review worth reading, giving pause to how truly (in)effective many common FDA approved are compared to placebo. How effective are common medications: a perspective based on meta-analyses of major drugs. Leucht et al. BMC Medicine (2015) Abstract The vastness of clinical data...

Highlights The overall quality of medical research remains poor, despite longstanding criticisms. The scientific enterprise is business-like and consistently undervalues its own backbone, methodology. Despite great initiatives to improve research quality, progress is modest. Top-down action...

"Abstract We use publicly available data to show that published papers in top psychology, economics, and general interest journals that fail to replicate are cited more than those that replicate. This difference in citation does not change after the publication of the failure to replicate. Only...

The methodological quality of 176,620 randomized controlled trials published between 1966 and 2018 reveals a positive trend but also an urgent need for improvement Christiaan H. Vinkers, Herm J. Lamberink, Joeri K. Tijdink, Pauline Heus, Lex Bouter, Paul Glasziou, David Moher, Johanna A. Damen...

Highlights • Prevalence of diagnoses were lower in the diagnostic interview than in self-reported questionnaires. • Discrepancies constituted the clinical evaluation of symptom attribution and impairment. • Symptom questionnaires are an important screening tool. • Diagnostic interviews are...

Abstract Background During storage, red blood cells (RBCs) undergo significant biochemical and morphologic changes, referred to collectively as the “storage lesion”. It was hypothesized that these defects may arise from disrupted oxygen‐based regulation of RBC energy metabolism, with resultant...

Copied from this thread: Independent advisory group for the full update of the Cochrane review on exercise therapy and ME/CFS (2020), led by Hilda Bastian Leaving some notes here regarding caveats when critiquing most common features of some researchers' claims about trial methodology and...

Might be interesting, sadly it's paywalled. A series of failed replications and frauds have raised questions regarding self-correction in science. Metascientific activists have advocated policies that incentivize replications and make them more diagnostically potent. We argue that current...