pem

I thought It would be interesting to have a place to collect descriptions or accounts of living with other illnesses that include phenomena seemingly nearly identical to what we call PEM. For Mitochondrial disease, check out the thread: What differentiates ME/CFS from known primary...

Exercise leads to the release of a wide variety of substances, in the category of exerkines. https://www.nature.com/articles/s41574-022-00641-2 What if one or several of these exerkines were blunted in ME/CFS or, for some obscure reason, had a damaging effect instead of a health-promoting...

Guardian angels off duty? ME/CFS is Sustained by an Impaired Stress Response in the Central Nervous System Herbert Renz-Polster Abstract ME/CFS researchers agree that ME/CFS is a multisystem disease with a multitude of pathobiological features including endothelial dysfunction, immune...

I thought it might be worthwhile to have a discussion comparing and contrasting the symptoms of an acute infection (a week or two of flu, cold, staph, etc.) and ME/CFS. Viral persistence is often mentioned in discussions of mechanism theories. I personally think there's a good chance ME/CFS is...

Chiara Gattoni, Asghar Abbasi, Carrie Ferguson, Charles W. Lanks, Thomas W. Decato, Harry B. Rossiter, Richard Casaburi, William W. Stringer, Two-Day Cardiopulmonary Exercise Testing in Long COVID Post-Exertional Malaise Diagnosis, Respiratory Physiology & Neurobiology, 2024, 104362, ISSN...

Background: Three systematic reviews all concluded that exercise is an effective treatment for long COVID. Objective: To determine if exercise therapy is also an effective treatment for long COVID patients who suffer from Post-Exertional Malaise (PEM) or Post-Exertional Symptom Exacerbation...

I have started this thread in order to reduce diversion of another thread where the subject arose. Here are a couple of quotes from that thread: My questions for discussion: pwME experiences: Is the worsening of symptoms triggered by sensory stimuli such as light and sound the same from a...

Objective Post-exertional malaise (PEM) is a common and debilitating symptom of post-acute COVID-19 syndrome (PACS), and it is also included in the core outcome set for PACS. Our aims are to determine the prevalence of PEM in patients with PACS, and to review the measurement tools utilized in...

How could someone draw, paint or otherwise visually portray these? [eta - over time] I want to do a creative project for myself but it's tricky to get going with this one... PEM Exertion intolerance / Fatiguability Random symptoms coming on for no apparent reason needing to sit or lie down I...

#MEAction and Patient-led Research Collaborative have created a four-part video series focusing on post-exertional malaise and pacing. Each video includes an interview with an expert conducted by Chimére L. Sweeney, a Long COVID author, speaker, filmmaker, and writer. We are thankful for the...

I get much more hungry during crashes. Not sure if it's anxious eating, since my anxiety also increases, or related to some mechanism of ME. I have been averaging around 2000 calories for a few weeks. I'm in a crash now from some intense computer focus sessions the past few days, and I'm at...

Schooltube https://www.schooltube.com/understanding-me-cfs-long-covid-and-post-exertional-malaise/

Towards an understanding of physical activity-induced post-exertional malaise: Insights into microvascular alterations and immunometabolic interactions in post-COVID condition and myalgic encephalomyelitis/chronic fatigue syndrome Haunhorst, Simon; Dudziak, Diana; Scheibenbogen, Carmen; Seifert...

New here. An ME blogger suggested I bring this idea here for discussion. Will leave out 9/10ths of this idea, looking to see if there's interest in discussion, and most importantly...facts which make this wrong. There’s a protein called myoglobin. It is expressed on muscle cells. One end of...

Discussion moved from this thread But the question is - what is 'exhaustion' in the context of ME/CFS. We have little evidence that it is actually depletion of energy reserves or a 'run down battery'. It certainly seems to feel like that but there is no shortage of oxygen or glucose and almost...

https://cdn.shopify.com/s/files/1/0873/0968/0927/files/240630_ACSM_Workwell_Lumia_Poster.pdf?v=1719881896 Blood Flow To The Head Is Reduced in a Patient With Myalgic Encephalomyelitis With Confirmed Post-Exertional Malaise Daniel Lee, Staci Stevens, Todd Davenport, Jared Stevens, Theresa...

Not sure if there are many other examples, but Ron Davis mentions one potentially successful case (or could be spontaneous remission) of someone recovering after avoiding crashes for a year: "One researcher had ME and she didn't have a crash and after a year she got better."

Cardiopulmonary and metabolic responses during a 2-day CPET in myalgic encephalomyelitis/chronic fatigue syndrome: translating reduced oxygen consumption to impairment status to treatment considerations Abstract Background Post-exertional malaise (PEM), the hallmark symptom of myalgic...

World Health Organization 22 – 24 May 2024 The Clinical Management and Operations Unit, WHO Health Emergencies Program supports a webinar program on post COVID-19 condition (also referred to as Long Covid). The series aims to build the capacity of clinicians globally to identify, diagnose, and...

In the patient community, it seems somewhat common to refer to instances where PEM (or a crash) led to worsening of the condition which was permanent. I have however yet to find a reference to this in the literature, if someone knows of one, I would be grateful as it is of interest to me, thanks!