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Abstract Objective: To explore the lived experience of ‘brain fog’—the wide variety of neurocognitive symptoms that can follow COVID-19. Design and setting: A UK-wide longitudinal qualitative study comprising online focus groups with email follow-up. Method: 50 participants were recruited from...

The Lancet New NICE guideline on chronic fatigue syndrome: more ideology than science? Signe A. Flottorp, Kjetil Brurberg, Per Fink, Hans Knoop, Vegard B B Wyller Article is paywalled other than this text (references removed): The National Institute for Health and Care Excellence (NICE) in the...

Abstract Objectives The aim of the study was to analyze adequacy of risk of bias (RoB) judgments for selective reporting in Cochrane systematic reviews. Study Design and Setting We extracted RoB assessments, including judgment (low, high, or unclear risk) and supporting comment from Cochrane...

Preprint https://www.researchsquare.com/article/rs-1344323/v1 Post-acute sequelae of COVID (PASC), or long COVID, is a multisystem complication of SARS-CoV-2 infection that continues to debilitate millions worldwide thus highlighting the public health importance of identifying effective...

Abstract Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is commonly associated with cognitive complaints. To bring out the neuropsychological symptomatology inherent to ME/CFS, we conducted a systematic review according to PRISMA and MOOSE guidelines of the literature through the...

[Yet another pointless FND review paper] Abstract Functional neurological disorder and somatic symptom disorder are complex neuropsychiatric conditions that have been linked to circuit-based dysfunction of brain networks. Neuromodulation is a novel therapeutic strategy capable of modulating...

Full title: The careful assessment tool for managing patients with medically unexplained symptoms – The experience of Slovenian family medicine trainees: A qualitative study Introduction: Primary care physicians use various tools and methods to identify medically unexplained...

Highlights • Functional seizures remains a complex neuropsychiatric condition to identify and treat. • Practitioners must address management of physical symptoms and underlying causes. • Management strategies can fail if their reasoning is not properly communicated. • Better outcomes may result...

Abstract The biopsychosocial model was defined by George L. Engel to propose a holistic approach to patient care. Through this model, physicians can understand patients in their context to aid the development of tailored, individualized treatment plans that consider relevant biological...

Abstract Cognitive post-acute sequelae of SARS-CoV-2 (PASC) can occur after mild COVID-19. Detailed clinical characterizations may inform pathogenesis. We evaluated 22 adults reporting cognitive PASC and 10 not reporting cognitive symptoms after mild SARS-CoV-2 infection through structured...

Lessons from Myalgic Encephalomyelitis/Chronic Fatigue Syndrome for Long COVID: Postexertional Symptom Exacerbations is an Abnormal Response to Exercise/Activity Authors: Todd E. Davenport, Staci R. Stevens, Jared Stevens, Christopher R. Snell, J. Mark Van Ness Quote: Prolonged symptoms after...

Abstract: The world continues to contend with successive waves of coronavirus disease 2019 (COVID-19), fueled by the emergence of viral variants. At the same time, persistent, prolonged and often debilitating sequelae are increasingly recognized in convalescent individuals, named...

Abstract Background: Long COVID is a condition characterized by long-term sequelae persisting after the typical convalescence period of COVID-19. Previous reports have suggested the role of an unsatisfactory immune response and impaired viral clearance in the pathogenesis of long COVID...

Abstract Background The immunopathological pathways enabling post-COVID syndrome (PCS) development are not entirely known. We underwent a longitudinal analysis of patients with COVID-19 who developed PCS aiming to evaluate the autoimmune and immunological status associated with this condition...

Abstract Objectives People living with long COVID describe a high symptom burden, and a more detailed assessment is needed to inform rehabilitation recommendations. The objectives were to use validated questionnaires to measure the severity of fatigue and compare this with normative data and...

Abstract Background: Long COVID, an illness affecting a subset of individuals after COVID-19, is distressing and poorly understood. Exploring the experiences of people with long COVID could help inform current conceptualizations of the illness, guide supportive care strategies, and validate...

Full title: Generalised worry in patients with Chronic Fatigue Syndrome following Cognitive Behavioural Therapy - a prospective cohort study in secondary care Highlights • Generalised worry is highly prevalent in Chronic Fatigue Syndrome (CFS). • Worry was linked with greater fatigue, anxiety...

Highlights Genetics of gut motility via data on stool frequency in 167,875 individuals GWAS identifies 14 loci associated with stool frequency Candidate genes enriched in neurotransmitter signaling and enteric motor neurons Polygenic scores predict increased risk of irritable bowel syndrome...

Key Points Question What is the association of a COVID-19 diagnosis and mobility and physical function among community-living middle-aged and older Canadians during the initial pandemic lockdown in 2020? Findings This cohort study of 24 114 participants found that community-living...

Main paper Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system of unknown etiology. We tested the hypothesis that MS is caused by Epstein-Barr virus (EBV) in a cohort comprising more than 10 million young adults on active duty in the US...