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Donna Brown, Camille Birch, Jarred Younger, Elizabeth Worthey UAB Medicine Link to the abstract Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) also referred to as Systemic Exertion Intolerance Disease (SEID) or Chronic Fatigue Immune Dysfunction Syndrome, is a disabling and...

Abstract Objective: Psychosocial trauma was associated with developing conversion disorder (also known as functional neurological disorder) before Freud, though why a particular symptom should arise is unknown. We aimed to determine if there was a relationship between trauma type and symptom...

Abstract Background High sodium intake is recommended for the treatment of postural tachycardia syndrome (POTS) to counteract the hypovolemia and elevated plasma norepinephrine that contribute to excessive orthostatic tachycardia, but evidence of its efficacy is not available. Objectives This...

Now published, see https://www.s4me.info/threads/qualitative-study-of-the-acceptability-and-feasibility-of-acceptance-and-commitment-therapy-for-adolescents-with-cfs-2021-crawley-et-al.20297/page-2#post-382771 preprint Is it time to ACT? A qualitative study of the acceptability and feasibility...

Ashok Gupta is citing this study as 'proof' that his programme is a cure for ME/CFS. Given that he is now actively targeting Covid LongHaulers, I thought it best to bring this to the attention of S4ME's resident experts. According to the comments on this youtube video, there are allegedly "3...

Abstract Coronavirus disease 2019 (COVID-19) is a viral infection which can cause a variety of respiratory, gastrointestinal, and vascular symptoms. The acute illness phase generally lasts no more than 2–3 weeks. However, there is increasing evidence that a proportion of COVID-19 patients...

Randomised clinical trial: high-dose oral thiamine versus placebo for chronic fatigue in patients with quiescent inflammatory bowel diseas, Bager et al https://pubmed.ncbi.nlm.nih.gov/33210299/ Health Rising had a guest blog feauturing this study...

Highlights • Prevalence of diagnoses were lower in the diagnostic interview than in self-reported questionnaires. • Discrepancies constituted the clinical evaluation of symptom attribution and impairment. • Symptom questionnaires are an important screening tool. • Diagnostic interviews are...

obviously not new. " Summary Background The PACE trial found that, when added to specialist medical care (SMC), cognitive behavioural therapy (CBT), or graded exercise therapy (GET) were superior to adaptive pacing therapy (APT) or SMC alone in improving fatigue and physical functioning in...

This looks sympathetic, though I haven't read it through. https://www.tandfonline.com/doi/full/10.1080/08870446.2021.1901900 Psychology & Health. 2021 Apr 19;1-17. doi: 10.1080/08870446.2021.1901900. Online ahead of print. What is it like to live with medically unexplained physical symptoms...

Abstract The National Institute for Health and Care Excellence (NICE) describe “post COVID-19 syndrome” or “Long COVID” as a set of persistent physical, cognitive and/or psychological symptoms that continue for more than 12 weeks after illness and which are not explained by an alternative...

Abstract Background Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a complex and debilitating disease accompanied by muscular fatigue and pain. A functional measure to assess muscle fatigability of ME/CFS patients is, however, not established in clinical routine. The aim of this...

"Highlights • Adolescents with CFS, asthma and healthy controls undertook an exercise task. • Those with CFS took longer to complete a laboratory-based exercise task than controls. • They (and their parents) expected to perform worse. • They were more anxious pre-task and rated their performance...

ABSTRACT Background We followed college students before, during, and after infectious mononucleosis (IM) for the development of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Aim We used network analysis to study relationships between pre-illness cytokine data amongst three...

Abstract Background and Objectives: The aetiology and pathomechanism of fibromyalgia syndrome 12 (FMS) as one of chronic pain syndromes still need to be further elucidated. Mitogen-activated protein kinase (MAPK) pathway has been proposed as a novel approach in pain management. Since the major...

Abstract Background: Chronic Fatigue Syndrome (CFS/ME) may get in the way of enjoying activities. A substantial minority of adolescents with CFS/ME are depressed. Anhedonia is a core symptom of depression. Anhedonia in adolescents with CFS/ME has not been previously investigated. Method: One...

Abstract Central Sensitization (CS) has been proposed as a common pathophysiological mechanism to explain related syndromes for which no specific organic cause can be found. The term Central Sensitivity Syndrome (CSS) has been proposed to describe these poorly understood disorders related to...

Abstract Impairment of health after overcoming the acute phase of COVID-19 is being observed more and more frequently. Here different symptoms of neurological and/or cardiological origin have been reported. With symptoms, which are very similar to the ones reported but are not caused by...

Objective: To report a case series of patients with neuropathic POTS and cutaneous phosphorylated alpha-synuclein (P-SYN) deposition on skin biopsy and compare these to neuropathic POTS patients without P-SYN deposition. Methods: The medical history, physical examination findings, autonomic...

OBJECTIVES--To determine the symptomatic and functional status during follow up of patients referred to hospital with unexplained fatigue and to identify patient variables associated with persistent functional impairment. DESIGN--Follow up by postal questionnaire six weeks to four years...