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The p38/MK2 Axis in Monocytes of Fibromyalgia Syndrome Patients: An Explorative Study, 2021, Nugraha,Scheibe et al

Discussion in ''Conditions related to ME/CFS' news and research' started by Sly Saint, Apr 19, 2021.

  1. Sly Saint

    Sly Saint Senior Member (Voting Rights)

    Background and Objectives: The aetiology and pathomechanism of fibromyalgia syndrome 12 (FMS) as one of chronic pain syndromes still need to be further elucidated. Mitogen-activated protein kinase (MAPK) pathway has been proposed as a novel approach in pain management.

    Since the major symptom of fibromyalgia syndrome (FMS) patients is pain, it became of interest whether MAPK pathways, such as the stress-activated p38 MAPK/MK2 axis, are activated in FMS patients. Therefore, this study aimed at determining p38 MAPK/MK2 in FMS patients.

    Materials and Methods: Phosphorylation of MAPK-activated protein kinases 2 (MK2), a direct target of p38 MAPK, was measured in monocytes of FMS and healthy controls (HCs) to monitor the activity of this pathway.

    Results: The mean level of phosphorylated MK2 was fivefold higher in FMS patients as compared to HCs (p < 0.001). Subgroup analysis revealed that antidepressants did not influence the activity of MK2 in FMS patients.

    Conclusions: This result indicates that the p38/MK2 pathway could be involved in the pathomechanism of FMS, could act as a clinical marker for FMS, and could be a possible target for pain management in FMS patients.

    Last edited by a moderator: Apr 19, 2021
    Milo, Hutan, alktipping and 5 others like this.
  2. Hutan

    Hutan Moderator Staff Member

    The starting point and the wrapping of this study is that fibromyalgia is the result of stress. The arguments for that are weak, with the issues including the validity of the assessment of depression in people with a debilitating chronic illness and with pain. And this study did not find a relationship between their chosen biomarker and depression, although it's a bit murky.
    Setting all that aside, the biological finding of an increase in the MK2 molecule in this small study is interesting, suggesting that fibromyalgia may be some sort of inflammatory condition.
    Screen Shot 2021-04-20 at 10.08.37 AM.png
    shak8, Milo, Trish and 1 other person like this.

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