metabolomics

  1. SNT Gatchaman

    [Preprint] Immunometabolic rewiring in long COVID patients with chronic headache, 2023, Cleveland Clinic

    Immunometabolic rewiring in long COVID patients with chronic headache Suan-Sin Foo, Weiqiang Chen, Kyle L Jung, Tamiris Azamor, Un Yung Choi, Pengfei Zhang, Suzy AA Comhair, Serpil C Erzurum, Lara Jehi, Jae U Jung Almost 20% of patients with COVID-19 experience long-term effects, known as...
    • SNT Gatchaman
    • Thread
    • arginine ceramide gaba headache immunometabolic kynurenine lipid metabolism lipids long covid metabolomics nitric oxide pro-inflammatory proteomics serotonin sphingomyelin
    • Replies: 0
    • Forum: Long Covid research
  2. Sly Saint

    Urine Metabolomics Exposes Anomalous Recovery after Maximal Exertion in Female ME/CFS Patients 2023, Glass, Hanson et al

    Abstract Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating disease with unknown etiology or effective treatments. Post-exertional malaise (PEM) is a key symptom that distinguishes ME/CFS patients. Investigating changes in the urine metabolome between ME/CFS patients...
  3. Andy

    A patient-centric modeling framework captures recovery from SARS-CoV-2 infection, 2023, Ruffieux et al

    Abstract The biology driving individual patient responses to severe acute respiratory syndrome coronavirus 2 infection remains ill understood. Here, we developed a patient-centric framework leveraging detailed longitudinal phenotyping data and covering a year after disease onset, from 215...
    • Andy
    • Thread
    • innate immune system kynurenine lipidomics long covid metabolomics nicholson nk cells
    • Replies: 7
    • Forum: Long Covid research
  4. RedFox

    Using an untargeted metabolomics approach to analyze serum metabolites in COVID-19 patients with nucleic acid turning negative

    Hot off the press, just published today in Frontiers in Pharmacology. A group of researchers in China used metabolomics (measuring the concentration of many metabolism-related chemicals in the blood) to compare healthy controls with Covid-19 patients who were admitted to Jiaxing Hospital, but...
    • RedFox
    • Thread
    • amino acids covid-19 fatty acid metabolism metabolism metabolomics
    • Replies: 1
    • Forum: Long Covid research
  5. cassava7

    Personalized microbiome-driven effects of non-nutritive sweeteners on human glucose tolerance, Suez et al, 2022

    Highlights Randomized-controlled trial on the effects of non-nutritive sweeteners in humans Sucralose and saccharin supplementation impairs glycemic response in healthy adults Personalized effects of non-nutritive sweeteners on microbiome and metabolome Impacts on the microbiome are causally...
  6. cassava7

    Tryptophan metabolites in cerebrospinal fluid of ME/CFS patients, Maccallini, 2022

    I present here a comparison between the levels of tryptophan (Trp), kynurenine (Kyn), serotonin (Ser), Kyn/Trp, and Ser/Trp in cerebrospinal fluid of 44 ME/CFS patients vs 21 sedentary controls. Raw data were retrieved from (Baraniuk JN et al. 2021). Stratification by sex has been included in...
    • cassava7
    • Thread
    • cerebrospinal fluid kynurenine metabolites metabolomics tryptophan
    • Replies: 5
    • Forum: ME/CFS research
  7. Sly Saint

    Metabolomic Evidence for Peroxisomal Dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, 2022, Levine,Hornig,Lipkin et al

    Threads for the preprint and final paper have ben merged. Abstract for the final paper here. PREPRINT Evidence for Peroxisomal Dysfunction and Dysregulation of the CDP-Choline Pathway in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Xiaoyu Che, Christopher R Brydges, Yuanzhi Yu, Adam...
    • Sly Saint
    • Thread
    • bateman cdp-choline energy fish oil hornig komaroff levine lipkin me/cfs metabolomics montoya pasc peroxisome phospholipids sphingolipids sphingomyelin
    • Replies: 56
    • Forum: ME/CFS research
  8. Kalliope

    Plasma metabolomics reveals disrupted response and recovery following maximal exercise in ME/CFS, Arnaud Germain, Maureen R. Hanson et al, 2022

    JCI Insight Plasma metabolomics reveals disrupted response and recovery following maximal exercise in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Abstract Post-exertional malaise (PEM) is a hallmark symptom of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). We monitored...
  9. leokitten

    Integrated analysis of plasma and single immune cells uncovers metabolic changes in individuals with COVID-19, 2021, Lee et al

    Pure speculation but maybe this line of research or the methods used in the paper to understand immune cell metabolic reprogramming via single-cell multiomics could eventually help explain whatever possible cellular metabolic changes that are triggered and persist in Long COVID and ME/CFS…...
  10. Kalliope

    biomolecules: Bioenergetic and Proteomic Profiling of Immune Cells in ME/CFS Patients: An Exploratory Study - Fernandez-Guerra et al - 2021

    biomolecules: Bioenergetic and Proteomic Profiling of Immune Cells in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients: An Exploratory Study Fernandes-Guerra et al Abstract Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a heterogeneous, debilitating, and complex...
    • Kalliope
    • Thread
    • 2021 acetyl co a atp coenzyme a denmark fernandez-guerra me/cfs metabolomics mitochondria mitochondrial dysfunction paper proteomics pyruvate dehydrogenase complex seahorse
    • Replies: 9
    • Forum: ME/CFS research
  11. Andy

    The serum metabolome of COVID-19 patients is distinctive and predictive, Shi et al, 2021

    Open access, https://www.metabolismjournal.com/article/S0026-0495(21)00039-1/fulltext
  12. ME/CFS Skeptic

    Multi-omics Examination of Q Fever Fatigue Syndrome Identifies Similarities with Chronic Fatigue Syndrome (Preprint, 2020) Raijmakers et al.

    Abstract: Full preprint available at: https://www.researchsquare.com/article/rs-54097/v1
    • ME/CFS Skeptic
    • Thread
    • 2020 4e-bp1 integrins me/cfs metabolomics microbiome mmp-1 paper proteomics q fever q fever fatigue syndrome raijmakers van der meer
    • Replies: 16
    • Forum: ME/CFS research
  13. Sly Saint

    A systematic review of mitochondrial abnormalities in ME/CFS/systemic exertion intolerance disease, 2020, Holden et al.

    A systematic review of mitochondrial abnormalities in myalgic encephalomyelitis/chronic fatigue syndrome/systemic exertion intolerance disease https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-020-02452-3
    • Sly Saint
    • Thread
    • 2020 griffith university holden marshall-gradisnik me/cfs metabolomics mitochondria paper review staines
    • Replies: 6
    • Forum: ME/CFS research
  14. Sly Saint

    A systematic review of metabolomic dysregulation in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis/ (CFS/ME/SEID):Huth,Staines et al May 2020

    A systematic review of metabolomic dysregulation in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis/Systemic Exertion Intolerance Disease (CFS/ME/SEID) Teilah Kathryn Huth, Natalie Eaton-Fitch, Donald Staines & Sonya Marshall-Gradisnik...
    • Sly Saint
    • Thread
    • 2020 huth marshall-gradisnik me/cfs metabolic dysregulation metabolomics paper review staines
    • Replies: 6
    • Forum: ME/CFS research
  15. Sly Saint

    Metabolomics in Central Sensitivity Syndromes : Miller, Saona, Hackshaw Apr 2020

    https://www.mdpi.com/2218-1989/10/4/164/htm eta:
    • Sly Saint
    • Thread
    • 2020 central sensitivity syndrome central sensitization css hacksaw me/cfs metabolomics miller paper
    • Replies: 3
    • Forum: ME/CFS research
  16. Andy

    Metabolomics in Psychiatric Disorders: What We Learn from Animal Models, 2020, Humer et al

    Open access, https://www.mdpi.com/2218-1989/10/2/72
  17. R

    Robert Naviaux' Lab - News - from 2019 onwards

    http://naviauxlab.ucsd.edu/wp-content/uploads/2019/12/Naviaux-Lab-Newsletter-Winter-2019_v10_sm.pdf P.5 "Other exciting studies include a new collaboration with the brilliant virologist, Dr. Bhupesh Prusty at the University of Würzburg, Germany. Using a new, cell-based assay system, we are hot...
    • Ron
    • Thread
    • bhupesh prusty extracellular atp metabolomics naviaux suramin
    • Replies: 66
    • Forum: ME/CFS research news
  18. Sly Saint

    Comprehensive Circulatory Metabolomics in ME/CFS Reveals Disrupted Metabolism of Acyl Lipids and Steroids: Levine,Hanson et al 2020

    Article. PDF Received: 20 December 2019; Accepted: 12 January 2020; Published: 14 January 2020...
    • Sly Saint
    • Thread
    • 2020 acyl lipids bile acid circulation levine maureen hanson me/cfs metabolism metabolomics paper sphingolipids steroids susan levine
    • Replies: 40
    • Forum: ME/CFS research
  19. D

    Insights into the pathogenesis of ME/CFS through metabolomic profiling of cerebrospinal fluid, 2018, Fiehn - Preliminary results

    Link I thought I'd post this preliminary finding here so it gets some exposure. Credit to @wigglethemouse for digging in and finding this study. I believe it's part of Columbia's ME/CFS CFE and hopefully will be published soon.
    • dreampop
    • Thread
    • 2018 ccl11 cerebral spinal fluid columbia me/cfs metabolomics oliver fiehn paper pathogenesis
    • Replies: 3
    • Forum: ME/CFS research
  20. Andy

    Video, Emerge Symposium 2019: Dr Neil McGregor, An Omic Analysis of ME/CFS – an Assessment of Potential Mechanisms

    Thought his was an interesting presentation, https://mecfsconference.org.au/videos/neil-mcgregor/ As a spoiler, here is his last slide, summarising his main points
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