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Insights into the pathogenesis of ME/CFS through metabolomic profiling of cerebrospinal fluid, 2018, Fiehn - Preliminary results

Discussion in 'BioMedical ME/CFS Research' started by dreampop, Nov 23, 2019.

  1. dreampop

    dreampop Senior Member (Voting Rights)

    I thought I'd post this preliminary finding here so it gets some exposure. Credit to @wigglethemouse for digging in and finding this study. I believe it's part of Columbia's ME/CFS CFE and hopefully will be published soon.
    Last edited by a moderator: Nov 23, 2019
    merylg, ahimsa, Simon M and 20 others like this.
  2. wigglethemouse

    wigglethemouse Senior Member (Voting Rights)

    Columbia did do cytokine analysis of cerebrospinal fluid and reported results in 2015. I wonder if the metabolimics was performed on the same samples but not published so far? Simmaron funded the cytokine work.

    Cytokine network analysis of cerebrospinal fluid in myalgic encephalomyelitis/chronic fatigue syndrome, 2015, Lipkin et al
    Here is a link to the Simmaron hosted write-up of the study by Cort
    Title : Simmaron’s Spinal Fluid Study Finds Dramatic Differences in Chronic Fatigue Syndrome
  3. dreampop

    dreampop Senior Member (Voting Rights)

    Your probably right since both have the identical numbers of subjects (32me/cfs, 40ms, 19 hc).
    mariovitali, Andy and wigglethemouse like this.
  4. mariovitali

    mariovitali Senior Member (Voting Rights)

    I am very excited with this research, Oliver Fiehn's lab uses cutting edge analytical techniques that may help ME research tremendously

    The findings are really interesting, here are my two cents :

    a) Upon looking the four available DNA files from Dante Labs i currently have, all of them (including myself) have pathogenic SNPs to MBL2, associated with Mannose-Binding Lectin deficiency. (2 with rs5030737, 2 with rs1800450). Whether this has anything to do with lower mannose levels in CSF i do not know.

    Mannose-binding lectin and ME patients study :


    b) Upon closer inspection to Mannose, we read (Bold letters added by me):

    We note, N-Linked Glycosylation, Glucose-6-phosphate and Hexokinase. All of these topics were discussed on a document sent to Professor Ron Davis in 2017, from which i provide some snapshots:

    Screen Shot 2019-11-25 at 08.34.44.png


    Screen Shot 2019-11-25 at 08.39.54.png

    Could low mannose levels be a consequence of impaired N-Linked glycosylation ?

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