1. Guest, the 'News in Brief' for the week beginning 23rd March 2020 can be found here.
    Dismiss Notice
  2. Welcome! To read the Core Purpose and Values of our forum, click here.
    Dismiss Notice

Insights into the pathogenesis of ME/CFS through metabolomic profiling of cerebrospinal fluid, 2018, Fiehn - Preliminary results

Discussion in 'BioMedical ME/CFS Research' started by dreampop, Nov 23, 2019.

  1. dreampop

    dreampop Senior Member (Voting Rights)

    Messages:
    193
    Likes Received:
    1,070
    Link
    I thought I'd post this preliminary finding here so it gets some exposure. Credit to @wigglethemouse for digging in and finding this study. I believe it's part of Columbia's ME/CFS CFE and hopefully will be published soon.
     
    Last edited by a moderator: Nov 23, 2019
    merylg, ahimsa, Simon M and 20 others like this.
  2. wigglethemouse

    wigglethemouse Senior Member (Voting Rights)

    Messages:
    520
    Likes Received:
    3,333
    Columbia did do cytokine analysis of cerebrospinal fluid and reported results in 2015. I wonder if the metabolimics was performed on the same samples but not published so far? Simmaron funded the cytokine work.

    Cytokine network analysis of cerebrospinal fluid in myalgic encephalomyelitis/chronic fatigue syndrome, 2015, Lipkin et al
    https://www.nature.com/articles/mp201529
    Here is a link to the Simmaron hosted write-up of the study by Cort
    Title : Simmaron’s Spinal Fluid Study Finds Dramatic Differences in Chronic Fatigue Syndrome
    http://simmaronresearch.com/2015/04...ramatic-differences-chronic-fatigue-syndrome/
     
  3. dreampop

    dreampop Senior Member (Voting Rights)

    Messages:
    193
    Likes Received:
    1,070
    Your probably right since both have the identical numbers of subjects (32me/cfs, 40ms, 19 hc).
     
    mariovitali, Andy and wigglethemouse like this.
  4. mariovitali

    mariovitali Senior Member (Voting Rights)

    Messages:
    398
    Likes Received:
    2,169
    I am very excited with this research, Oliver Fiehn's lab uses cutting edge analytical techniques that may help ME research tremendously

    The findings are really interesting, here are my two cents :


    a) Upon looking the four available DNA files from Dante Labs i currently have, all of them (including myself) have pathogenic SNPs to MBL2, associated with Mannose-Binding Lectin deficiency. (2 with rs5030737, 2 with rs1800450). Whether this has anything to do with lower mannose levels in CSF i do not know.

    Mannose-binding lectin and ME patients study :

    https://www.sciencedirect.com/science/article/abs/pii/S0198885915004656

    b) Upon closer inspection to Mannose, we read (Bold letters added by me):


    We note, N-Linked Glycosylation, Glucose-6-phosphate and Hexokinase. All of these topics were discussed on a document sent to Professor Ron Davis in 2017, from which i provide some snapshots:


    Screen Shot 2019-11-25 at 08.34.44.png

    and

    Screen Shot 2019-11-25 at 08.39.54.png


    Could low mannose levels be a consequence of impaired N-Linked glycosylation ?
     

Share This Page