Introduction. After the acute form of COVID-19, 10 to 30% of patients tend to develop a post-covid syndrome or long-COVID-19. Research is actively being conducted into the causes of long-term COVID-19, one of which may be a violation of the immune response after SARS-CoV2 enters the body as a...
Cardiovascular and haematological pathology in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): A role for viruses
Nunes, Kell, Pretorius
ME/CFS is a debilitating chronic condition that often develops after viral or bacterial infection. Insight from the study of Long COVID/Post...
The herpes simplex virus hides in the body’s immune cells, increasing its survival chances. This finding from offers a new target for vaccines to clear latent infection.
Abstract
A hallmark of herpes simplex virus (HSV) infection is the establishment of latent virus in peripheral sensory...
"Herpes simplex virus (HSV) establishes latency in ganglionic neurons of the peripheral nervous system, from which it can reactivate, causing recurrent disease and possible transmission to a new host. Current anti-HSV therapy does not eliminate latent HSV, and thus is only suppressive rather...
Alzheimer’s disease can begin almost imperceptibly, often masquerading in the early months or years as forgetfulness that is common in older age. What causes the disease remains largely a mystery.
But researchers at Tufts University and the University of Oxford, using a three-dimensional human...
In mice.
Abstract
Epstein-Barr virus (EBV) infection is associated with rheumatoid arthritis (RA) in adults, though the nature of the relationship remains unknown. Herein, we have examined the contribution of viral infection to the severity of arthritis in mice. We have provided the first...
Myalgic encephalomyelitis/chronic fatigue syndrome and gulf war illness patients exhibit increased humoral responses to the herpesviruses-encoded dUTPase: Implications in disease pathophysiology
Peter Halpin 1, Marshall Vance Williams 1 2, Nancy G Klimas 3 4, Mary Ann Fletcher 3 4, Zachary...
Full title:
Salivary DNA loads for human herpes viruses 6 and 7 are correlated with disease phenotype in Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome
https://www.medrxiv.org/content/10.1101/2021.01.06.20248486v1
This study received significant funding from the US NIH but it doesn't seem a paper will be published. I'm guessing they only received funding for R21 to do feasibility work and that work allowed them to develop a test but only test a small cohort.
US NIH Project Description
Source ...
There are at least eight herpes virus variants that infect humans. These include:
Human herpes virus 1 (HHV1) is also known as herpes simplex virus 1 (HSV1).
Human herpes virus 2 (HHV2) is also called herpes simplex virus 2 (HSV2).
Human herpes virus 3 (HHV3) is also called varicella-zoster...
Another look to see if the immune antibody signature to Human Herpes virus's in patients is different to controls.
https://www.frontiersin.org/articles/10.3389/fimmu.2019.01946/full
Significance
Inflammatory processes drive the autoimmune disease multiple sclerosis (MS).
However, what triggers this inflammation re- mains unknown.
Several herpesviruses (HHVs), such as HHV-6 typically acquired during childhood, are associated with MS.
The temporal separation between...
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