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Antibodies to Human Herpesviruses in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients (2019) Blomberg et al

Discussion in 'BioMedical ME/CFS Research' started by wigglethemouse, Aug 15, 2019.

  1. wigglethemouse

    wigglethemouse Senior Member (Voting Rights)

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    Another look to see if the immune antibody signature to Human Herpes virus's in patients is different to controls.
    https://www.frontiersin.org/articles/10.3389/fimmu.2019.01946/full
     
    Last edited: Aug 15, 2019
  2. Michiel Tack

    Michiel Tack Senior Member (Voting Rights)

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    If I understood correctly it's not about exposure to herpesviruses cause these are ubiquitous and IgG did not differ between patients and controls.

    If these viruses do play a role in ME/CFS, as some EBV-studies suggest, it is probably because the immune system of some ME/CFS patients respond differently to herpesviruses.

    The authors of this study think that the minor differences they have found in antibody reactivities in ME/CFS samples versus controls with whole virus HHV-1 antigens and recombinant EBV EBNA6 and EA antigens form an indication for this.
     
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  3. beverlyhills

    beverlyhills Established Member (Voting Rights)

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    People that die from oncogenic viral brain tumors do not have any evidence of serological antibodies to their giant brain tumors that make them die.

    HHV exists in lymphatics for transmission purposes at best. So do a biopsy of the lymph nodes or a lumbar puncture (you will not get very robust results) but for sure do not this.
     
  4. Ravn

    Ravn Senior Member (Voting Rights)

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    Drumroll please: presenting a paper that does not start with a version of "ME is a fatiguing condition":
    Can anybody explain what 'degree of reactivity' means?
     
  5. JemPD

    JemPD Senior Member (Voting Rights)

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    :thumbup:
     
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  6. Andy

    Andy Committee Member (& Outreach when energy allows)

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    Commentary: Antibodies to Human Herpesviruses in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients
    Open access, https://www.frontiersin.org/articles/10.3389/fimmu.2020.01400/full
     
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  7. wigglethemouse

    wigglethemouse Senior Member (Voting Rights)

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    The author Maria Ariza has published several papers with Marshall Williams and it looks like they are part of the same team looking at EBV. This is her profile
    https://loop.frontiersin.org/people/170539/publications

    For background Marshall Williams has a long standing ME/CFS grant which was renewed for another 5 years this year (year 11 of grant, year 6 for ME/CFS I believe).
    https://projectreporter.nih.gov/project_info_description.cfm?aid=10049715&icde=31258613
     
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  8. wigglethemouse

    wigglethemouse Senior Member (Voting Rights)

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    I think this is the meat and potatoes regarding Herpes Viruses and ME/CFS that the author is trying to get across
     
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