endothelium

Persistent endothelial dysfunction in post-COVID-19 syndrome and its associations with symptom severity and chronic inflammation Timon Kuchler; Roman Günthner; Andrea Ribeiro; Renate Hausinger; Lukas Streese; Anna Wöhnl; Veronika Kesseler; Johanna Negele; Tarek Assali; Javier Carbajo-Lozoya...

Significance ACh-releasing choline acetyltransferase (ChAT)+ T cells promote vasodilation and regulate blood pressure in mice, but human ChAT+ T cells and the molecular mechanisms by which ChAT-expression is regulated remain undefined. In this study, we identify primary ChAT+ T cells in patients...

We are conducting a study on endothelial function, upright activity and cognition in ME/CFS and Long Covid and collecting blood samples to assess for biomarkers. The study will require a 2-hour in-person visit and then will continue for seven days with tests and surveys that are done from the...

Defibrotide: potential for treating endothelial dysfunction related to viral and post-infectious syndromes Edward Richardson, David García-Bernal, Eleonora Calabretta, Rubén Jara, Marta Palomo, Rebecca M Baron, Gregory Yanik, Jawed Fareed, Israel Vlodavsky, Massimo Iacobelli, Maribel...

Transl Med Endothelial dysfunction and altered endothelial biomarkers in patients with post-COVID-19 syndrome and chronic fatigue syndrome (ME/CFS) Milan Haffke et al Abstract Background: Fatigue, exertion intolerance and post-exertional malaise are among the most frequent symptoms of...

Highlights • Patients hospitalized for COVID-19 display marked impairment in endothelial function, which is persistent following recovery from the acute infection. • Red blood cells (RBCs) from patients with COVID-19 impair vascular function through mechanisms involving increased arginase 1...

Decreased NO production in endothelial cells exposed to plasma from ME/CFS patients Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating disease characterized by severe and persistent fatigue. Along with clinical studies showing endothelial dysfunction (ED) in a...

Posts copied from The micro-clot finding in Long Covid — implications for the possible aetiology of ME/CFS...

Abstract Porphyromonas gingivalis (P. gingivalis), a key pathogen in periodontitis, has been shown to accelerate the progression of atherosclerosis (AS). However, the definite mechanisms remain elusive. Emerging evidence supports an association between mitochondrial dysfunction and AS. In our...

Abstract Background Persistent symptoms including breathlessness, fatigue and decreased exercise tolerance have been reported in patients after acute SARS-CoV-2 infection. The biological mechanisms underlying this ‘Long COVID’ syndrome remain unknown. However, autopsy studies have highlighted...

Myalgic encephalomyelitis/chronic fatigue syndrome is a serious illness of unknown etiology, characterized by debilitating exhaustion, memory impairment, pain and sleep abnormalities. Viral infections are believed to initiate the pathogenesis of this syndrome although the definite proof remains...