depression

Abstract The causes of depression are diverse and are still not fully understood. Recently, an increasing role is attributed to nutritional and inflammatory factors. The aim of this study was to evaluate selected metabolites of the tryptophan kynurenine pathway in depressive patients with small...

Abstract Introduction Brain fog has been described up to 1 year after SARS-CoV-2 infection, notwithstanding the underlying mechanisms are still poorly investigated. In this study, we aimed to evaluate the prevalence of cognitive complaints at 1-year follow-up and to identify the factors related...

Abstract Primary Sjögren’s syndrome (pSS) is an autoimmune disease with frequent neurological involvement. Memory complaints are common, but their precise patterns remain unclear. We wanted to characterize patterns of neurocognitive profiles in pSS patients with cognitive complaints. Only pSS...

Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions Major depression is a debilitating psychiatric illness that is typically associated with low mood and anhedonia. Depression has a heritable component that...

Joanna Moncrieff, Ruth E. Cooper, Tom Stockmann, Simone Amendola, Michael P. Hengartner & Mark A. Horowitz The serotonin hypothesis of depression is still influential. We aimed to synthesise and evaluate evidence on whether depression is associated with lowered serotonin concentration or...

Slide presentation: "Antidepressant withdrawal syndrome and its management" Dr Mark Horowitz BA, BSc, MBBS, MSc, PhD (IoPPN, KCL) Clinical Research Fellow on RADAR trial (UCL, NELFT) Psychiatry Trainee (Camden & Islington) m.horowitz@ucl.ac.uk...

Abstract Introduction This study examines the relationships among recent adverse childhood experiences (ACEs), somatic symptoms, and anxiety/depression symptoms during adolescence and whether anxiety/depression symptoms mediate the relationship between ACEs and somatic symptoms. Methods...

I wonder whether ME/CFS would be a better primary diagnosis for some of these people? https://www.sciencedirect.com/science/article/abs/pii/S0889159121000398 Brain, Behavior, and Immunity Volume 94, May 2021, Pages 259-265 Infectious mononucleosis as a risk factor for depression: A nationwide...

Highlights Longitudinal multiomics associate PASC with autoantibodies, viremia and comorbidities Reactivation of latent viruses during initial infection may contribute to PASC Subclinical autoantibodies negatively correlate with anti-SARS-CoV-2 antibodies Gastrointestinal PASC uniquely present...

https://www.psychologytoday.com/gb/blog/happiness-is-state-mind/202112/differentiating-fibromyalgia-depression-and-cfs I didn't read any further because if they still haven't got to grips with the diagnostic criteria.......

(Embargoed until 2099?) Oxford criteria, so tagged as "chronic fatigue", not applicable to ME/CFS. Philippa Clery*, Alexander Royston , Katie Driver, Jasmine Bailey, Esther M Crawley, Maria Loades...

Background: Persistent physical symptoms are common after a coronavirus disease 2019 (COVID-19) episode, but their pathophysiological mechanisms remain poorly understood. In this study, we aimed to explore the association between anxiety and depression at 1-month after acute infection and the...

ABSTRACT Background Fibromyalgia (FM) is associated with sexual dysfunction, though much less is known about the sexual desire, and especially dyadic and solitary sexual desire, among women with fibromyalgia. Aim To investigate on the one hand the global sexual desire, the dyadic sexual and...

"Millions of people with mild depression in England should be offered therapy, exercise, mindfulness or meditation before antidepressants, according to the first new NHS guidelines in more than a decade. Under draft guidance, the National Institute for Health and Care Excellence (Nice)...

Abstract Irritable bowel syndrome (IBS) is one of the functional gastrointestinal disorders characterized by chronic and/or recurrent symptoms of abdominal pain and irregular defecation. Changed gut microbiota has been proposed to mediate IBS; however, contradictory results exist, and...

Do adolescents with chronic fatigue syndrome (CFS/ME) and co-morbid anxiety and/or depressive symptoms think differently to those who do not have co-morbid psychopathology? 2020 Loades, Crawley et al Abstract Background Co-morbid anxiety and/or depression is common in adolescents with Chronic...

A Systematic Review and Meta-analysis Key Points Question What is the placebo effect magnitude in different treatment modalities used for management of patients with treatment-resistant depression? Findings In this systematic review and meta-analysis of 3228 patients with...

Abstract Control conditions are the primary methodology used to reduce threats to internal validity in randomized controlled trials (RCTs). This meta-analysis examined the effects of control arm design and implementation on outcomes in RCTs examining psychological treatments for depression. A...

Full reference: Berger, D. (2015). Double-blinding and bias in medication and cognitive-behavioral therapy trials for major depressive disorder. F1000Research, 4. Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4732552/ Abstract:

Just came across this and thought it might be of interest (its not new, its from 2004) Moncrieff, J., Wessely, S., & Hardy, R. (2004). Active placebos versus antidepressants for depression. Cochrane database of systematic reviews, CD003012.PUB2...