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Altered metabolome and microbiome features provide clues in understanding irritable bowel syndrome and depression comorbidity, 2021, Han et al

Discussion in 'Other health news and research' started by Andy, Nov 10, 2021.

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  1. Andy

    Andy Committee Member

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    Hampshire, UK
    Abstract

    Irritable bowel syndrome (IBS) is one of the functional gastrointestinal disorders characterized by chronic and/or recurrent symptoms of abdominal pain and irregular defecation. Changed gut microbiota has been proposed to mediate IBS; however, contradictory results exist, and IBS-specific microbiota, metabolites, and their interactions remain poorly understood.

    To address this issue, we performed metabolomic and metagenomic profiling of stool and serum samples based on discovery (n = 330) and validation (n = 101) cohorts. Fecal metagenomic data showed moderate dysbiosis compared with other diseases, in contrast, serum metabolites showed significant differences with greater power to distinguish IBS patients from healthy controls. Specifically, 726 differentially abundant serum metabolites were identified, including a cluster of fatty acyl-CoAs enriched in IBS. We further identified 522 robust associations between differentially abundant gut bacteria and fecal metabolites, of which three species including Odoribacter splanchnicus, Escherichia coli, and Ruminococcus gnavus were strongly associated with the low abundance of dihydropteroic acid. Moreover, dysregulated tryptophan/serotonin metabolism was found to be correlated with the severity of IBS depression in both fecal and serum metabolomes, characterized by a shift in tryptophan metabolism towards kynurenine production.

    Collectively, our study revealed serum/fecal metabolome alterations and their relationship with gut microbiome, highlighted the massive alterations of serum metabolites, which empower to recognize IBS patients, suggested potential roles of metabolic dysregulation in IBS pathogenesis, and offered new clues to understand IBS depression comorbidity. Our study provided a valuable resource for future studies, and would facilitate potential clinical applications of IBS featured microbiota and/or metabolites.

    Open access, https://www.nature.com/articles/s41396-021-01123-5
     
  2. Trish

    Trish Moderator Staff Member

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    Location:
    UK
    This looks like a very thorough paper with some interesting results.
    So different from the crap we see from Rona-Moss Morris and her like with their CBT for IBS studies.

    I found it interesting that they didn't find significant differences in microbiome between IBS and healthy participants, but did find significant differences in some serum metabolites, including some also associated with depression in people with IBS.
     
  3. DokaGirl

    DokaGirl Senior Member (Voting Rights)

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    Interesting study.

    The ME specialist I saw said IBS may develop before ME.

    Not, I think that IBS leads to ME. I believe there are many pwME without IBS. But the many paths one mountain concept may apply here.

    My own IBS became much more painful when the ME worsened.
     
    Peter Trewhitt, Andy and Trish like this.

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