I've been following the microbiome literature daily for 4+ years while cataloging it all into this wiki: https://old.reddit.com/r/HumanMicrobiome/wiki/ There is tremendous support for FMT being close to a panacea with the major caveat being that the donor is in perfect health, with an unperturbed, disease-resistant, curative gut microbiome. It's currently looking like fewer than 0.4% of the population qualifies: https://archive.fo/JmcMV#selection-1525.120-1525.121 I've done DIY FMTs from 9 different donors, published my detailed results and lessons: https://docs.google.com/document/d/1cagQpzRCa7Uy8QZYV6NiywDhPELBlzHxUk1OWPR3kNM/, and shared it with hundreds of researchers. First I emailed all 180 authors running current FMT clinical trials https://archive.fo/YZ7Xk#selection-1603.11-1607.1 to complain about, and advocate for higher donor quality. Then I emailed dozens more USA-based IBS and CFS researchers who were authors on papers listed in the wiki to see if they'd be able to run an FMT clinical trial with high quality donors. I emailed the major microbiome research centers in California. I emailed CFS and IBS advocacy groups to ask who I should contact. A journal editor advised me to contact American Gasto Assoc authors on IBS guidelines, and US authors on the Rome Foundation IBS guidelines - same for the CFS researchers. I did that as well and still no takers. From my view, anyone in a position to do something about it has their head up their ass. Among professionals involved in FMT/microbiome there seems to be a large amount of ignorance, apathy, myopic focus on one tiny piece of the puzzle, and resistance to reviewing relevant information and investigating its merit. There might be a few researchers who are the exception, but they don't seem to have the capability to run a clinical trial. I'm so sick of this. There's likely a cure right now, and it's easy as hell to obtain, given the right people try to obtain it. I contacted the Norweigian guys doing a CFS FMT study to share info on what makes a high quality donor and urged them to find one. I don't know if they bothered to do so and we won't find out till 2023 - when the study ends. I'm not waiting around. I'm going to start writing to newspapers now.