1. Read all the 'News In Brief' from w/c 21st May. Click to read.
    Dismiss Notice

Vitamin D status in chronic fatigue syndrome/myalgic encephalomyelitis: a cohort study from the North-West of England

Discussion in 'BioMedical ME/CFS Research' started by Adrian, Nov 10, 2017.

  1. Adrian

    Adrian Administrator

    Messages:
    1,995
    Likes Received:
    9,987
    Location:
    UK
    1. Kate E Earl, Giorgos K Sakellariou, Melanie Sinclair, Manuel Fenech, Fiona Croden, Daniel J Owens, Jonathan Tang, Alastair Miller, Clare Lawton, Louise Dye, Graeme L Close, William D Fraser, Anne McArdle, Michael B J Beadsworth

    Abstract
    Objective Severe vitamin D deficiency is a recognised cause of skeletal muscle fatigue and myopathy. The aim of this study was to examine whether chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) is associated with altered circulating vitamin D metabolites.

    Design Cohort study.

    Setting UK university hospital, recruiting from April 2014 to April 2015.

    Participants Ninety-two patients with CFS/ME and 94 age-matched healthy controls (HCs).

    Main outcome measures The presence of a significant association between CFS/ME, fatigue and vitamin D measures.

    Results No evidence of a deficiency in serum total 25(OH) vitamin D (25(OH)D2 and 25(OH)D3 metabolites) was evident in individuals with CFS/ME. Liquid chromatography tandem mass spectrometry (LC–MS/MS) analysis revealed that total 25(OH)D was significantly higher (p=0.001) in serum of patients with CFS/ME compared with HCs (60.2 and 47.3 nmol/L, respectively). Analysis of food/supplement diaries with WinDiets revealed that the higher total 25(OH) vitamin D concentrations observed in the CFS/ME group were associated with increased vitamin D intake through use of supplements compared with the control group. Analysis of Chalder Fatigue Questionnaire data revealed no association between perceived fatigue and vitamin D levels.

    Conclusions Low serum concentrations of total 25(OH)D do not appear to be a contributing factor to the level of fatigue of CFS/ME.

    This is an Open Access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 4.0) license, which permits others to distribute, remix, adapt and build upon this work, for commercial use, provided the original work is properly cited. See: http://creativecommons.org/licenses/by/4.0/


    http://dx.doi.org/10.1136/bmjopen-2016-015296
     
    Esther12, TigerLilea, Barry and 12 others like this.
  2. Amw66

    Amw66 Senior Member (Voting Rights)

    Messages:
    611
    Likes Received:
    3,710
    A narrow look at vit D. It underwrites around 5% of your whole genome and is integral to immune system. It would perhaps have been better to look at levels when first diagnosed .

    We had to push to be taken seriously requesting this and had some very sheepish faces at the surgery when results came back.
     
    Dolphin, Maria1, NelliePledge and 4 others like this.
  3. JaimeS

    JaimeS Senior Member (Voting Rights)

    Messages:
    173
    Likes Received:
    1,291
    Location:
    Stanford, CA
    Yes, my levels are normal NOW.... because I take quite a bit. Even if you tell the patient to stop taking supplements, Vit D levels take awhile to drop. Note there's no mention (that I can find, happy to be corrected) of whether or not patients were taking anything.

    Note this is UK, they used Chalder fatigue scale, probably used Oxford dx.

    All together this means not worth the pixels it's rendered with. ;)
     
    Pibee, dannybex, TigerLilea and 10 others like this.
  4. Adrian

    Adrian Administrator

    Messages:
    1,995
    Likes Received:
    9,987
    Location:
    UK
    Yes had a similar experience.

    I think there is some research in terms of MS that suggests that vitamin D (or the lack of it) effects the strength of the blood brain barrier.

    I'm not sure we should take a paper looking for associations between the CFQ and anything seriously. Its too poor a questionnaire to do such stats on.
     
    Barry, Andy, Hutan and 5 others like this.
  5. MeSci

    MeSci Senior Member (Voting Rights)

    Messages:
    716
    Likes Received:
    4,579
    Location:
    Cornwall, UK
    The summary says: "Analysis of food/supplement diaries with WinDiets revealed that the higher total 25(OH) vitamin D concentrations observed in the CFS/ME group were associated with increased vitamin D intake through use of supplements compared with the control group."
     
    JaimeS, Andy, Sly Saint and 1 other person like this.
  6. JaimeS

    JaimeS Senior Member (Voting Rights)

    Messages:
    173
    Likes Received:
    1,291
    Location:
    Stanford, CA
    Sorry, @MeSci -- are you saying that ppl who were taking Vit D were, or were not included when they were determining who was low?

    If those ppl were included OR excluded that's bad science, though:

    1) Included -- well of course their Vit D wasn't low; they are taking it
    2) Excluded -- well of course the rest of the group shows no sign of low Vit D -- the ones who had low Vit D were taking it

    Vitamin D being low is one of the most common causes of chronic fatigue, the symptom. I was tested for it very early on. Since it was low, I was advised to start taking supplements. I'm sure this is the case for many, many others.
     
    dannybex, inox, Maria1 and 4 others like this.
  7. Adrian

    Adrian Administrator

    Messages:
    1,995
    Likes Received:
    9,987
    Location:
    UK
    It doesn't quite work like that in the UK. I had a doctor who said Vitamin D wasn't important as its low in half the population. GPs don't like to test and don't really know what to do when its bad.
     
    Amw66, dannybex, Wonko and 2 others like this.
  8. MeSci

    MeSci Senior Member (Voting Rights)

    Messages:
    716
    Likes Received:
    4,579
    Location:
    Cornwall, UK
    I have no idea.
     
  9. Arnie Pye

    Arnie Pye Senior Member (Voting Rights)

    Messages:
    679
    Likes Received:
    3,707
    Location:
    UK
    That might explain why a very young child in the UK died of rickets recently :

    https://www.shropshirestar.com/news...er---rickets-caused-telford-baby-noahs-death/


     
    dannybex, Wonko, Helen and 3 others like this.
  10. JaimeS

    JaimeS Senior Member (Voting Rights)

    Messages:
    173
    Likes Received:
    1,291
    Location:
    Stanford, CA
    ?! ... weird!
     
    MeSci, TigerLilea, Adrian and 3 others like this.
  11. JaimeS

    JaimeS Senior Member (Voting Rights)

    Messages:
    173
    Likes Received:
    1,291
    Location:
    Stanford, CA
    Perhaps their point is that hypovitaminosis D is not causing their patients' chronic fatigue in which case yes, they've made their case.

    Here is other research, also UK, done better; all of these have noted marked depression of Vit D levels in patients:

    https://www.ncbi.nlm.nih.gov/pubmed/25455721
    https://www.ncbi.nlm.nih.gov/pubmed/20209476

    Interestingly a study on "chronic fatigue" (the symptom) showed a correlation between low Vit D and orthostatic intolerance, which many studies have noted has a high incidence in ME/CFS:

    https://www.ncbi.nlm.nih.gov/pubmed/21886073
     
    MeSci, Andy, Scarecrow and 4 others like this.
  12. Esther12

    Esther12 Senior Member (Voting Rights)

    Messages:
    1,474
    Likes Received:
    11,534
    Vitamin D is the only supplement I take. I'm able to get outside so little that it seems a sensible thing to do. I've got CFS... I need to take at least one pill of some sort a day!
     
    JaimeS, Skycloud, MeSci and 2 others like this.
  13. Amw66

    Amw66 Senior Member (Voting Rights)

    Messages:
    611
    Likes Received:
    3,710
    Yes, in UK it' s associated with bone health.
     
    JaimeS and MeSci like this.
  14. Skycloud

    Skycloud Senior Member (Voting Rights)

    Messages:
    828
    Likes Received:
    6,204
    Location:
    UK
    I asked a GP at my surgery for a vit D test. I had already been supplementing with D3. She understood when I explained why it would be very reasonable in my case to check it but said that 'they' often refused to do the test because of the cost. Together we wrote a detailed account of why I needed it to prevent refusal and it went through ok.

    (I looked up on line and I could have had it done myself for about £80-£90.)

    When the results came, the GP misunderstood the results (I don't think she had any experience with vit D tests at all, and hadn't looked it up)

    The results showed low D2 and lowish D3. She was a bit concerned that my levels were low given that I was supplementing and decided to refer me to a specialist. The (very nice) consultant explained that there was nothing wrong with my vitD levels because you have to add together the D2 and D3! He told me to carry on with what I was doing, and wrote a nice letter to my GP putting her right.

    Wasted NHS appointment, wasted time and energy, husbands time off work, PEM. Sigh.
     
  15. Amw66

    Amw66 Senior Member (Voting Rights)

    Messages:
    611
    Likes Received:
    3,710
    UK vit D " normal range" is very low ( as it is based on bone health). So normal dosn' t count for much.
     
    JaimeS and Wonko like this.
  16. Skycloud

    Skycloud Senior Member (Voting Rights)

    Messages:
    828
    Likes Received:
    6,204
    Location:
    UK
    True. I increased my D3 following my test for that reason. I don't think I would be able to get another test on the NHS.
     
    JaimeS and Wonko like this.
  17. Amw66

    Amw66 Senior Member (Voting Rights)

    Messages:
    611
    Likes Received:
    3,710
    JaimeS, Skycloud, MeSci and 4 others like this.
  18. Skycloud

    Skycloud Senior Member (Voting Rights)

    Messages:
    828
    Likes Received:
    6,204
    Location:
    UK
    Now that's interesting! When I looked online, and it was maybe 3 or 4 years ago(?) there was nothing available as cheaply as that, and I think it was somewhere in Birmingham that I considered. Same place? Anyway, it indicates to me that there has been a demand for vit D testing such that it's worthwhile to develop it (shiny webpage) and lower prices. That's good, thanks for posting.
     
    Trish and Scarecrow like this.
  19. Amw66

    Amw66 Senior Member (Voting Rights)

    Messages:
    611
    Likes Received:
    3,710
    I don' t know how recent it is. I habe a friend who is studying nutritional therapy and gets her levels tested there every year- so perhaps a couple of years
     
    Trish and Skycloud like this.

Share This Page