1. Sign our petition calling on Cochrane to withdraw their review of Exercise Therapy for CFS here.
    Dismiss Notice
  2. Guest, the 'News in Brief' for the week beginning 19th February 2024 is here.
    Dismiss Notice
  3. Welcome! To read the Core Purpose and Values of our forum, click here.
    Dismiss Notice

Video presentation: Autonomic regulation of glucose in POTS, 2020 Cyndya Shibao

Discussion in ''Conditions related to ME/CFS' news and research' started by Ryan31337, Jun 4, 2021.

  1. Ryan31337

    Ryan31337 Senior Member (Voting Rights)

    Presentation from Dr Cyndya Shibao including apparent early data from an unpublished pilot study into autonomic regulation of glucose in POTS.

    Very interesting video for those of us here that experience postprandial (after eating) problems, I know these issues have been discussed a fair bit over the years here. When mild its usually just the "food coma" slowdown. When severe it can have many symptoms of a hypoglycaemic event and be very, very disabling.

    I've experienced the full spectrum of this. Certainly when milder with less ANS dysfunction I didn't recognise the impact eating was having on my CFS symptoms & fatigability. Even when it insidiously became a significant issue, one that eventually eclipsed my general CFS/POTS issues, it still wasn't obvious to me until a POTS-aware endocrinologist pointed out what was happening. Much like how many of us don't realise we experience orthostatic intolerance until we are told - these weird problems just get mixed in to the confusing gamut of CFS symptoms.

    A few summary slides on the study to follow but the new headlines appears to be:

    - 50% of lean POTS patients have impaired glucose tolerance (IGT) with higher risk of developing Type 2 Diabetes.
    - The IGT has a distinct pathophysiology that may not respond to conservative measures like weight loss.
    - POTS patients have increased incretin hormone GIP that is potentially responsible for postprandial increased heart rate.
    - GIP antagonist is under trial & might be a useful therapeutic.

    Splanchnic pooling has been implicated in this for a long time and this incretin finding seems to reinforce that. Pleased to see controls for the gastric emptying issues that often get reported in POTS too.

    Last edited: Jun 4, 2021
    Chris, alktipping, jaded and 4 others like this.
  2. Ryan31337

    Ryan31337 Senior Member (Voting Rights)

    From the video:
    Last edited: Jun 4, 2021
    sb4, Chris, ukxmrv and 4 others like this.
  3. Hoopoe

    Hoopoe Senior Member (Voting Rights)

    Thanks for sharing. This is what I have I think, except that it was there even when I didn't have POTS. It's likely to be partially genetic in my case.

    PEM, OI, strange blood glucose regulation problems, fatigue, brain fog, low blood pressure and others might just be an expression of an autonomic nervous system problem.
    Chris, alktipping and Ryan31337 like this.

Share This Page