Dr. Peter Vadas - CME Presentation: Mast Cells Gone Wild - Mast Cell Activation Disorders https://www.youtube.com/watch?v=HQQrMcKIOhA First 20 minutes are an introduction and offsetting MCAS against mastocytosis. After that he focuses on the type of MCAS that overlaps with POTS and EDS, mentioning the following article: JJ Lyons et al. Elevated basal serum tryptase identifies a multisystem disorder associated with increased TPSAB1 copy number. Nature Genetics DOI: 10.1038/ng.3696 (2016). https://www.ncbi.nlm.nih.gov/pubmed/27749843 He also discusses the higher incidence of various autoimmune conditions among these people and considers MCAS could potentially have autoimmune basis as well. If that turns out to be the case it would have consequences for treatment, shifting it from symptomatic to targeting the autoimmune process. No mention of ME, but potentially interesting for some nevertheless.