1. Guest, the 'News in Brief' for the week beginning 11th January 2021 is here.
    Dismiss Notice
  2. Welcome! To read the Core Purpose and Values of our forum, click here.
    Dismiss Notice

Open UK: Brighton and Sussex University Hospital and Medical School - Chronic Pain and Fatigue

Discussion in 'Recruitment into current ME/CFS research studies' started by RuthT, Sep 30, 2018.

  1. Andy

    Andy Committee Member & Outreach

    Messages:
    11,730
    Likes Received:
    84,259
    Location:
    Hampshire, UK
  2. Jonathan Edwards

    Jonathan Edwards Senior Member (Voting Rights)

    Messages:
    8,149
    Likes Received:
    84,743
    It does seem worrying that they advertised for people interested in ME/fibro research about autonomic dysfunction and then discovered that the patients had signs of autonomic dysfunction. How do we know that this was not because people who knew they had autonomic dysfunction were keen to apply?

    I also did not get any clear idea of what hypothesis was being tested. It all seems very vague and general. I would have preferred to see something focusing in on something very specific.
     
  3. NelliePledge

    NelliePledge Moderator Staff Member

    Messages:
    7,166
    Likes Received:
    42,388
    Location:
    UK West Midlands
    https://www.actionforme.org.uk/reso...brain-inflammation-phd-study-you-are-funding/

    first part reads
    What's the brain inflammation study you're funding?
    Led by: Dr Neil Harrison, Reader in Neuropsychiatry and Neuroimaging, Brighton and Sussex Medical School

    Aims: An increasing body of work suggests alteration in brain structure and function in M.E./CFS using magnetic resonance imaging (MRI). Additionally there is growing evidence that immune system and autonomic nervous system function is altered in ME/CFS.

    Recruiting a PhD student, this project will focus on differences in brain activity between people with M.E./CFS and fibromyalgia using state-of-the-art HCP (Human Connectome Project) resting state functional connectivity imaging.

    It aims to investigate the neural responses to mild inflammation and how these might contribute to fatigue, post-exertional malaise and pain, and correlate with abnormalities of interoception, immune and autonomic nervous system function and metabolism.

    Specifically, this project seeks to answer the following questions:

    • Do patients with M.E./CFS present with differences in neural connectivity as measured by resting-state functional connectivity (rfMRI) compared to controls?
    • Do patients with M.E./CFS show different connectivity responses to an inflammatory stimulus compared to controls?
    • Do these differences in functional connectivity correlate with altered interoception, dysautonomia or levels of inflammation in the blood measured with gene expression (transcriptomics) and metabolism (metabolomics)?
    • Can we use the answers to these questions to inform targeted research into the neurobiological mechanisms of M.E./CFS and highlight possible treatment targets in the future to enhance understanding of this often poorly understood condition and improve the lives of patients?
     
    obeat, rvallee, MEMarge and 2 others like this.
  4. Andy

    Andy Committee Member & Outreach

    Messages:
    11,730
    Likes Received:
    84,259
    Location:
    Hampshire, UK
  5. Andy

    Andy Committee Member & Outreach

    Messages:
    11,730
    Likes Received:
    84,259
    Location:
    Hampshire, UK

Share This Page