Traumatic brain injury - similarities with and differences to ME/CFS, including PEM

Has anyone ever had all their pituitary and hypothalamus hormones tested (there are quite a lot of them) after severe illness or injury affecting the brain?

According to this link : https://en.wikipedia.org/wiki/List_of_human_hormones

(I'm dubious about the following numbers because I wasn't sure which column I should be counting!)

Anterior pituitary produces 8 hormones
Posterior pituitary produces 2 hormones
Hypothalamus produces 8 hormones

I don't think its true that if one hormone from the pituitary or hypothalamus is low that they will all be low. Nor that if one hormone is absent they will all be absent - but they might be.

 

I want to look into this as I have a few abnormalities indicating I could have some hormonal issues.

 

Could PEM be, when neuron action potential fires, use of atp, atp require mitochondria and defective mitochondria generates more ROS, and then ROS causes DAMPS release from within the cell itself that the mitochondria is in, and that DAMPS released then activate glial cells which causes Inflammation cause pain and fatigue via activating pain nerves?
Do ROS damage the cells that they are released from?

Here i am just learning the very basics of biology and wondering

 

I was pleased to watch this too.

At least for rugby playing men an FND misdiagnosis would be less likely due to Neurologists’ bias.
Has the former player poster boy for LP/The Switch been active lately? EDIT - He’s doing fine Life Coaching & NLP& TV presenting etc - so obviously it was not CTE for him.

 

Here is an old NYT article that empathized with ME/CFS patients after the columnist suffered concussion fatigue for a month. She didn't mention anything about her PEM though, so I asked AI for fun. The answer was: "While fatigue is a common symptom of post-concussion syndrome (PCS), post-exertional malaise (PEM), characterized by a worsening of symptoms after physical or mental exertion, is not a core defining feature of PCS like it is for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)"

It makes sense to me though, that PCS and ME/CFS should share features. The brain's immune system must get activated to make repairs after concussion and that obviously causes debilitating fatigue in PCS. But I can't think of a reason why PCS should involve PEM. In microglial model of ME/CFS, there are cells that are primed to get activated and they presumably cause PEM. PCS on the other hand involves normal activation. But maybe it's possible for some concussion to cause cells to get primed as well as activated.

 

PCS does involve something that could be described as PEM though (at least a vague definition of worsening of symptoms after physical or mental exertion is very common, edit: an example where an athlete describes developing brain fog following physical activity). A majority of people with PCS describes something somewhat akin to this and from what I've heard treatment often also used to be "lie in a dark room until you feel better" whilst now it is, more often than not, seems to be something more akin to GET. I'm however not sure whether there is a delayed form of PEM though or whether it always tends to be instant in PCS. As far as I understand the cause of fatigue in PCS is unknown, what is obvious about "immune system activation causing fatigue" what exactly is it supposed to mean when nobody knows what PCS entails?

 

The old evidence based medicine tricking people into short term measures bolstered by false hope (and the natural frustration all humans have at not wanting to lie in a dark room) vs science and logic combined with long term outcomes

 

That was a poor choice of word on my part. I should've said "probably", not "obviously". "Probably" because immune system activation usually entails fatigue. Microglial activation in concussion has been observed, so the activation part is probably more than "probably".